Predictors of survival in posterior cricoid squamous cell carcinoma: A study of 248 cases

Din, Hassieb; Zhan, Kevin Y.; Boling, Caitlin; Nguyen, Shaun A.; Lentsch, Eric J.

doi:10.1002/lary.26372

Cited by 5 publications

(2 citation statements)

References 20 publications

(81 reference statements)

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“…Lastly, we analyzed the impact of LC extension to different subsites and found that involvement of the retro-cricoid area is a strong predictor for distant failure, especially at multivariable analysis (HR 5.42, p = 0.005). The best way to look at this finding is probably to compare it with what has been described for primary retro-cricoid hypopharyngeal carcinoma, frequently presenting with positive nodal disease and usually reported to have a poor prognosis with a 5-year OS ranging from 20% to 52% [ 38 , 39 ]. This type of localization, together with the piriform sinus, as pointed out in a large retrospective series [ 40 ], is prone to distant metastasis with a 17.2% rate.…”

Section: Discussionmentioning

confidence: 99%

Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy

Marchi

Missale

Sampieri

et al. 2020

Cancers

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A picture is emerging in which advanced laryngeal cancers (LCs) are potentially not homogeneous and may be characterized by subpopulations which, if identified, could allow selection of patients amenable to organ preservation treatments in contrast to those to be treated with total laryngectomy (TL). This work aims to analyze a multicentric cohort of T3-T4a LCs treated by upfront TL, investigating the clinical and pathological features that can best predict oncologic outcomes. A total of 149 previously untreated patients who underwent TL for T3-T4a LC at four institutions were analyzed. Survival and disease-control were considered as the main outcomes. A secondary end-point was the identification of covariates associated with nodal status, investigating also the tumor thickness. T and N categories were significantly associated with both overall and disease-specific survival. The number of positive nodes and tracheal involvement were associated with loco-regional failure; post-cricoid area invasion and extra-nodal extension with distant failure. Posterior laryngeal compartment involvement was not a significant prognostic feature, by either univariable and multivariable analyses. These results support the conclusion that laryngeal compartmentalization has no impact on survival in patients treated by upfront TL and the current TNM staging system remains a robust prognosticator in advanced LC.

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Section: Discussionmentioning

confidence: 99%

Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy

Marchi

Missale

Sampieri

et al. 2020

Cancers

View full text Add to dashboard Cite

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“…Negative predictors of survival include advanced age, male sex, advanced clinical stage, comorbidities, and poor performance scores. 21,[22][23][24][25]…”

Section: Prognosismentioning

confidence: 99%

Hypopharyngeal carcinoma: Do you know your guidelines?

Kwon

Miles

2018

Head & Neck

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Background Hypopharyngeal carcinoma is relatively rare, representing approximately 3% of all head and neck malignancies. It also is characterized by having one of the worst prognoses at time of diagnosis. This is largely due to its tendency for late presentation. Methods This article will review current literature including as well as the National Comprehensive NCCN Guidelines Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines) for the treatment of hypopharyngeal cancer. Results Hypopharyngeal cancer often presents in an advanced stage and its prognosis is notoriously poor. Treatment goals are similar to other carcinomas of the head and neck and treatment typically involves multiple modalities including surgery, radiation, and chemotherapy. Organ sparing nonsurgical therapy has shown comparable survival outcomes to surgery in early stage hypopharyngeal cancer. Conclusion Treating hypopharyngeal cancer remains a challenging prospect for the head and neck oncologist. A multidisciplinary approach is essential due to the necessity of combined therapy treatment protocols. There is opportunity for novel treatments and prospective trials to improve outcomes in hypopharyngeal carcinoma. Disease prevention by targeting environmental risk factors is likely to have the greatest impact in this disease.

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Optimizing Survival Predictions of Hypopharynx Cancer: Development of a Clinical Prediction Model

et al. 2019

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Objectives To develop and validate a clinical prediction model (CPM) for survival in hypopharynx cancer, thereby aiming to improve individualized estimations of survival. Methods Retrospective cohort study of hypopharynx cancer patients. We randomly split the cohort into a derivation and validation dataset. The model was fitted on the derivation dataset and validated on the validation dataset. We used a Cox's proportional hazard model and least absolute shrinkage and selection operator (LASSO) selection. Performance (discrimination and calibration) of the CPM was tested. Results The final model consisted of gender, subsite, TNM classification, Adult Comorbidity Evaluation‐27 score (ACE27), body mass index (BMI), hemoglobin, albumin, and leukocyte count. Of these, TNM classification, ACE27, BMI, hemoglobin, and albumin had independent significant associations with survival. The C Statistic was 0.62 after validation. The model could significantly identify clinical risk groups. Conclusions ACE27, BMI, hemoglobin, and albumin are independent predictors of overall survival. The identification of high‐risk patients can be used in the counseling process and tailoring of treatment strategy or follow‐up. Level of Evidence 4 Laryngoscope , 130:2166–2172, 2020

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Predictors of survival in posterior cricoid squamous cell carcinoma: A study of 248 cases

Abstract: 4. Laryngoscope, 127:1093-1096, 2017.

Cited by 5 publications

References 20 publications

Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy

Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy

Hypopharyngeal carcinoma: Do you know your guidelines?

Optimizing Survival Predictions of Hypopharynx Cancer: Development of a Clinical Prediction Model

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