Magnesium depletion enhances cisplatin-induced nephrotoxicity.

Lajer, Henrik; Kristensen, M; Hansen, Heine H.; Nielsen, Søren; Frøkiær, Jørgen; Ostergaard, L F; Christensen, Sten; Daugaard, Gedske; Jonassen, Thomas E. N.

doi:10.1007/s00280-005-1010-7

Cited by 81 publications

(59 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study on Mg-depleted female rats treated with CP (2.5 mg/kg once weekly for 3 weeks) revealed an almost complete disappearance of Na,K-ATPase (alpha-subunit), Na/H-exchanger, and Na,K,2Cl-cotransporter, suggesting a dramatic synergistic effect of CP and Mg depletion on renal function including the expression pattern of outer medullary Na transporters (5). Our data did not show CP-caused changes in 24-h urinary Mg or 24-h K excretion in rats of both genders treated with CP (2.5 mg/kg once a day for 3 days).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cisplatin increases urinary sodium excretion in rats: gender-related differences

et al. 2010

View full text Add to dashboard Cite

Results. The 24-h urinary sodium excretion, sodium/chloride ratio, and diuresis showed no gender-related differences in control rats. After a single administration of 2.5 mg/kg cisplatin, 24-h urinary sodium excretion was not significantly higher in cisplatin-treated rats than in gender-matched controls. After repeated cisplatin administration, 24-h urinary sodium excretion was significantly higher in cisplatin-treated male rats as compared to matched controls (P<0.05). No such effect was found in cisplatin-treated female rats.Conclusion. The study data show that cisplatin enhances urinary sodium excretion in male but not in female rats. The mechanism of such a gender-related effect is not yet clear. Further investigations are necessary to elucidate the mechanism of this pharmacological effect of cisplatin.

show abstract

Section: Discussionmentioning

confidence: 99%

“…paštas: donatasstakisaitis@vvkt.lt solution 50 mg/100 mL, Ebewe Pharma Ges.m.b.H., A-4866 Unterach, Austria) into the caudal vein (once a day for 3 days) were examined. This dose was chosen in accordance with the literature data on preclinical CP pharmacodynamics (5).…”

Section: Methodsmentioning

confidence: 99%

Cisplatin increases urinary sodium excretion in rats: gender-related differences

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Hypomagnesemia reduces the expression of certain transporters in renal tubules in order to maintain serum Mg concentrations. This reduction in tubular transporters also amplifies the renal accumulation of cisplatin, which is accompanied by further nephrotoxicity (20)(21)(22). In this vicious cycle, we hypothesize that Mg supplementation protects against nephrotoxicity by blocking the augmented accumulation of cisplatin.…”

Section: Discussionmentioning

confidence: 99%

“…Large amounts of hydration with saline, mannitol and furosemide are accepted as the standard of care for patients treated with regimens containing high-dose (≥60 mg/m 2 ) cisplatin (3,10,11). Previous studies have demonstrated that Mg supplementation also confers protective effects against cisplatin-induced nephrotoxicity (10,(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Influence of magnesium and parathyroid hormone on cisplatin-induced nephrotoxicity in esophageal squamous cell carcinoma

et al. 2017

View full text Add to dashboard Cite

Abstract. Magnesium (Mg) supplementation has previously been demonstrated to confer protective effects against nephrotoxicity induced by cisplatin. Parathyroid hormone (PTH) regulates Mg homeostasis. The aim of present study was to determine the protective effects of Mg supplementation against cisplatin-induced nephrotoxicity and its association with PTH levels in patients with esophageal squamous cell carcinoma (ESCC). A total of 55 patients with primary ESCC who received chemotherapy with high-dose cisplatin were examined. Mg was administered intravenously, and serum concentrations of PTH, parathyroid hormone-related protein (PTH-rP), creatinine and Mg were prospectively measured. Of the 55 patients, 37 received Mg supplementation. Post-chemotherapeutic creatinine concentrations were significantly increased in patients without Mg supplementation (P=0.01), with grade 1 and 2 increases of 22.2 and 5.6%, respectively, whereas these increases were suppressed by Mg supplementation (change in creatinine, P=0.21), with grade 1 and 2 increases of 8.1 and 0%, respectively. In addition, PTH and PTH-rP concentrations were high in 8 (14.5%) and 6 (10.9%) of all 55 patients, respectively. Alterations in creatinine concentrations (post-/pre-chemotherapy) due to chemotherapy were higher in patients with high levels of PTH regardless of Mg supplementation (P<0.01). Pre-therapeutic creatinine concentrations did not correlate with the alterations in creatinine concentrations due to chemotherapy. Intravenous Mg supplementation therefore conferred protective effects against cisplatin-induced nephrotoxicity in patients with ESCC. Furthermore, increases in PTH or PTH-rP may have influenced the extent of nephrotoxicity.

show abstract

“…Hypomagnesemia was observed in humans (28) and in experimental animals (29). It was reported that in cisplatin-treated mice the urinary magnesium waste almost doubled (30), and the magnesium depletion was shown to enhance cisplatin nephrotoxicity (31). Magnesium is known to be a critical cofactor in many cellular enzyme processes including membrane transport and cellular repair (32).…”

Section: Discussionmentioning

confidence: 99%

Changes in the serum, liver, and renal cortical lipids and electrolytesin rabbits with cisplatin-induced nephrotoxicity

Abdel-Gayoum¹,

Ahmida²

2017

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: Cisplatin is an anticancer drug that can induce nephrotoxicity. Its toxicity is associated with dyslipidemia and disturbed electrolyte balance. In the present study we investigated the changes in serum lipid profile and electrolyte levels and their contents in kidney and liver tissues of rabbits treated with cisplatin.Materials and methods: Twenty-eight adult male New Zealand White rabbits were used in the experiment. Animals of groups C, P1, and P2 were injected with saline, cisplatin (4.0 mg/kg bw), and cisplatin (6.5 mg/kg bw), respectively, and killed 3 days after the injections. Animals of group R were given cisplatin (6.5 mg/kg bw) and killed after 7 days. All animals were killed after an overnight fast. Results:The P2 animals showed reductions in their body weights, significant (P < 0.001) increases in serum creatinine and urea levels, and significant (P < 0.001) drops in cortical alkaline phosphatase activity and necrotic kidney histology. The treatments had no effect on liver function. Moreover, the P2 animals showed increased serum cholesterol, TAG, and elevated LDL-cholesterol, with significant accumulations of the kidney cholesterol and TAG, but no change in serum phospholipid and depleted hepatic cholesterol. Moreover, the P2 animals had depressed serum levels of potassium, calcium, and magnesium, and reduced renal cortical calcium and magnesium contents and depressed liver calcium but not magnesium. However, the P1 animals had no significant alterations in their lipid or electrolyte levels. Most of the perturbed parameters returned to normal levels in the recovery group. Conclusion:Cisplatin nephrotoxicity in rabbits is accompanied by reductions in body weight, secondary dyslipidemia, and reduced serum potassium, calcium, and magnesium with depleted renal cortical magnesium and calcium and accumulated cortical lipids.

show abstract

Magnesium depletion enhances cisplatin-induced nephrotoxicity.

Cited by 81 publications

References 19 publications

Cisplatin increases urinary sodium excretion in rats: gender-related differences

Cisplatin increases urinary sodium excretion in rats: gender-related differences

Influence of magnesium and parathyroid hormone on cisplatin-induced nephrotoxicity in esophageal squamous cell carcinoma

Changes in the serum, liver, and renal cortical lipids and electrolytesin rabbits with cisplatin-induced nephrotoxicity

Contact Info

Product

Resources

About