Cisplatin increases urinary sodium excretion in rats: gender-related differences

Stakišaitis, Donatas; Dudeniene, Giedre; Jankūnas, Rimas Jonas; Grazeliene, G.; Didžiapetrienė, Janina; Pundzienė, Birutė

doi:10.3390/medicina46010008

Cited by 21 publications

(20 citation statements)

References 26 publications

(28 reference statements)

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“…In our study, CP increased serum levels of Cr, BUN, which was confirmed by pathological data. Our findings were in agreement with previous studies (14,(27)(28)(29)(30)(31). Histopathological examination showed that CP induces massive degenerative changes in 50 -75% of glomeruli and renal tubules (32) by mechanisms such as oxidative stress and apoptosis, and our histopathological investigation indicated that moderate regular exercise reduced KTDS.…”

Section: Discussionsupporting

confidence: 83%

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

et al. 2015

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Background: Cisplatin (CP) is a chemotherapy drug and nephrotoxicity is considered as its major side effect. Aerobic exercise is well known as an approach to reduce the side effects of many drugs. Objectives: This study was designed to determine the protective role of aerobic exercise against CP-induced nephrotoxicity. Materials and Methods: Thirty male Wistar rats were randomly divided into four groups. Group I had aerobic exercise on a treadmill one hour per day and five days per week for eight weeks. Then, the exercise protocol was continued for another week, but during this week, the animals also received CP (2.5 mg/kg/day; ip). Group II underwent the same protocol as group I without exercise in the last week during the CP therapy. Groups III and IV were assigned as positive and negative control groups, and were treated with CP and saline without exercise, respectively. Finally, the animals were sacrificed for the biochemical measurement and tissue histopathology investigation. Results: CP alone without exercise increased serum levels of blood urea nitrogen (BUN), creatinine (Cr), and malondialdehyde (MDA); and kidney nitrite level, while treadmill exercise in group I significantly ameliorated these parameters (P < 0.05). Kidney and serum levels of MDA and nitrite did not alter significantly. Also, the severity of kidney tissue damage decreased significantly in groups I and II (P < 0.05). Conclusions: Aerobic exercise may reduce CP-induced nephrotoxicity with a favorable effect on renal function by increasing activation of antioxidant system.

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Section: Discussionsupporting

confidence: 83%

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

et al. 2015

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“…Stakisaitis et al . found in rats that CDDP-related hyponatermia and renal toxicity is more pronounced in males than females, although the mechanism is not understood [22]. In human studies, tobacco and alcohol consumption were believed to be the major, but not the only, factors inducing the occurrence and recurrence of HNSCC.…”

Section: Resultsmentioning

confidence: 99%

Carrier-based intralymphatic cisplatin chemotherapy for the treatment of metastatic squamous cell carcinoma of the head & neck

Cai

Xie

Davies

et al. 2010

Therapeutic Delivery

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Background Since head and neck squamous cell carcinoma (HNSCC) preferentially metastasizes to the locoregional lymphatics, treatment of the tumor-draining cervical lymph nodes is paramount. Results We developed a hyaluronan–cisplatin (HA–Pt) nanoconjugate with prolonged lymphatic retention and greatly improved tumor tissue deposition for the treatment of metastatic HNSCC. We also developed an orthotopic metastatic xenograft model of HNSCC to examine the efficacy of the nanoconjugate. HNSCC (1/week × 3 weeks) were completely cured for 57% of the female mice in the HA–Pt treatment group, which demonstrated greatly hindered HNSCC progression compared with the standard cisplatin therapy (p < 0.05). Conclusion With this insight, we will be able to optimize the carriers for better uptake, penetration and retention within cancer cells.

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“…13,14 The role of gender in CP-induced nephrotoxicity is not well documented yet, but it is reported that urinary sodium excretion after CP administration is different in males and females. 15 Renin-angiotensin system (RAS) includes different receptors with different vascular responses. In addition to AT1, there are two other receptors; angiotensin II receptor 2 (AT2) and angiotensin-(1-7) receptor (Mas) in RAS, which are gender dependent, and the role of these receptors in females is more important than in males, especially in the absence of AT1.…”

Section: Introductionmentioning

confidence: 99%

The Role of Angiotensin II Receptor 1 (AT1) Blockade in Cisplatin-Induced Nephrotoxicity in Rats: Gender-Related Differences

et al. 2012

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It is documented that chronic renal diseases are gender related. The protective role of angiotensin II receptor 1 (AT1) blocker losartan against cisplatin (CP)-induced nephrotoxicity was reported in males, but the role of gender is not well known. Six groups of Wistar rats were studied. Rats were divided into two groups of males and females to receive losartan for 9 days plus a single dose of CP (7 mg/kg) at day 3. Two positive control groups of males and females received the same regimen, except that they received saline instead of losartan. The negative control groups received saline instead of CP at day 3 and also saline instead of losartan. The blood samples were obtained, and the kidneys underwent histopathological investigations. All the CP-treated animals lost weight, but losartan promoted weight loss in females (p < 0.05). Coadministration of losartan and CP in females, but not in males, significantly increased the serum levels of blood urea nitrogen and creatinine when compared with the negative and positive control groups (p < 0.05). No significant differences were observed in serum levels of total proteins, magnesium, and nitrite between the groups. Administration of CP increased the kidney tissue damage score (KTDS) and normalized kidney weight (p < 0.05). However, in the presence of AT1 blockade, the KTDS (nonsignificantly) and normalized kidney weight (significantly, p < 0.05) increased in the CPtreated females. Such an observation was not seen in males. Losartan may prevent CP-induced nephrotoxicity in males, but it promotes the CP-induced damage in females, which may be related to the renin-angiotensin system receptors in the kidneys.

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Cisplatin increases urinary sodium excretion in rats: gender-related differences

Cited by 21 publications

References 26 publications

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

Carrier-based intralymphatic cisplatin chemotherapy for the treatment of metastatic squamous cell carcinoma of the head & neck

The Role of Angiotensin II Receptor 1 (AT1) Blockade in Cisplatin-Induced Nephrotoxicity in Rats: Gender-Related Differences

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