Results. The 24-h urinary sodium excretion, sodium/chloride ratio, and diuresis showed no gender-related differences in control rats. After a single administration of 2.5 mg/kg cisplatin, 24-h urinary sodium excretion was not significantly higher in cisplatin-treated rats than in gender-matched controls. After repeated cisplatin administration, 24-h urinary sodium excretion was significantly higher in cisplatin-treated male rats as compared to matched controls (P<0.05). No such effect was found in cisplatin-treated female rats.Conclusion. The study data show that cisplatin enhances urinary sodium excretion in male but not in female rats. The mechanism of such a gender-related effect is not yet clear. Further investigations are necessary to elucidate the mechanism of this pharmacological effect of cisplatin.

National legislation on the drug reimbursement in Lithuania and Latvia does not provide safeguards for public health at the same level as the marketing authorization does. Absence of a revision of former decisions in the light of new evidence is a critical weakness of the drug reimbursement in Lithuania and Latvia. Reimbursement for the off-label indications may pose a risk to public health.

Summary. Depression is one of the leading causes of disability worldwide, affecting

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Airn, materials and methods: To find gender-related differences in blood pressure (BP) and urinary chloride excretion as well as a relation between them, we monitored diurnal, overnight, and 24-h urinary chloride as well as BP hourly in 22 adolescent males and 22 adolescent females. To show a possible influence of sexual honnones on chloride excretion and BP. we also tnonitored 15 adolescent females during different phases of their menstrual cycle. Results: The overnight systolic and pulse BP was significantly higher in males than in females. The diurnal pulse BP was significantly higher in tnales than in females at the beginning of follicular phase. The diurnal systolic, diastolic, and mean BP was significantly higher than nocturnal in all tbe groups studied. The overnight urinary chloride level in fctnales at the beginning of the follicular phase was significantly lower than during ovulation. Urinary chloride level during kiteal phase was comparable with that during ovulation. The total 24-h urinary chloride in the general group of males was signi ficantly h igher than in females at the beginning of follicular phase. In the general -group of fetnales, diurnal urinary chloride exeretion negatively correlated with diastolic and mean BP, but such a correlation was absent in males. Overnight, on the contrary, the correlation between urinary chloride excretion and [JP was absent in fetnales, but it was positive in tnales. The diurnal and overnight urinary chloride excretion exhibited a negative correlation with BP in females during luteal phase. A correlation between overnight chloride excretion and tncan BP was positive in tnales, but negative in females during luteal phase. Conclusion: BP, urinary chloride exeretion, and relation between them in adolescents are gender-and circadian cyclerelated. Sexual honnones tnay play a role botb in regulation of BP and urinary ehloride excretion.

The Assessment Report of pediatric study of BNT162b2 mRNA says that there was no cases of Covid-19 in 1119 adolescents 12 to 15 years of age administered vaccine (0%) and there were 18 cases in 1110 (1.6%) of those administered placebo [1]. The vaccine efficacy (Relative Risk Reduction, ARR) is 100% while the Absolute Risk Reduction (ARR) is 1.6 % (18/1119 -0/1110) [1]. Literally, BNT162b2 mRNA Covid-19 Vaccine prevented mild Covid-19 in 1.6% of the study population. At the cut-off date, no severe cases and no deaths were reported in 12 15 years-old age group1, i.e., no benefit in respect to prevention of severe or death Covid-19 was demonstrated. Prevention of long-term Covid-19 was not investigated.