Long term consequences on spatial learning-memory of low-calorie diet during adolescence in female rats; hippocampal and prefrontal cortex BDNF level, expression of NeuN and cell proliferation in dentate gyrus

Kaptan, Zulal; Akgün-Dar, Kadriye; Kapucu, Ayşegül; Dedeakayoğulları, Huri; Batu, Şule; Üzüm, Gülay

doi:10.1016/j.brainres.2015.05.041

Cited by 56 publications

(35 citation statements)

References 69 publications

(83 reference statements)

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“…The BDNF receptor is expressed on neural stem cells. We also demonstrated in a previous study that increased neurogenesis is correlated with elevated hippocampal BDNF levels and improvement in spatial memory in calorie-restricted adolescent female rats (19). The BDNF-neurogenesis-memory association is further evidenced by the decrease in hippocampal BDNF levels and receptors with aging, and the associated impairment in neurogenesis, learning, and memory functions (20).…”

Section: Factors That Affect Adult Hippocampal Neurogenesissupporting

confidence: 75%

“…In recent years, calorie restriction has also been suggested to increase neurogenesis through an unknown mechanism (7). In our above-mentioned study, we also found that a 15% calorie-restricted diet in adolescence increased hippocampal neurogenesis, even if a normal diet was assumed in adulthood (19). Our results suggested that calorie-restricted diet increases hippocampal BDNF levels to increase neurogenesis.…”

Section: Factors That Affect Adult Hippocampal Neurogenesissupporting

confidence: 68%

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The Role of Adult Hippocampal Neurogenesis in Learning and Memory Function

Kaptan¹,

Üzüm²

2016

tnd

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Adult hippocampal neurogenesis is the lifelong production of new functional neurons from neural stem cells in the adult brain. Production of neurons in the adult brain is limited to two areas. One of these is the subgranular region in the hippocampus dentate gyrus (DG), the other is the subventricular zone of the lateral ventricles. New neurons produced in the hippocampus DG functionally integrate into mature circuits, and contribute to cognition and emotional control, learning and memory functions in particular. It is still unclear how that contribution occurs and a key issue that is being intensively investigated. Hippocampal neurogenesis declines both with age and in neurodegenerative diseases characterized by deterioration of memory. Understanding the contribution of hippocampal neurogenesis to memory function and investigating factors that affect neurogenesis have gained importance for protective or therapeutic approaches against these neurodegenerative diseases. It is suggested that new neurons produced in the DG contribute to spatial and episodic memory function by pattern separation (prevent overlapping of similar information by making separate presentations) through their electrophysiologic properties (being stimulated easier than mature neurons) in the maturation process. Hippocampal neurogenesis is important in episodic and spatial memory formation. In this review we will try to explain how hippocampal neurogenesis occurs, factors that affect the neurogenesis process, and the role of neurogenesis in memory function based on the present literature.Keywords: Adult hippocampal neurogenesis, dentate gyrus, learning and memory, pattern separation Erişkin hipokampal nörogenez, erişkin beyninde yaşam boyu nöral kök hücrelerden yeni fonksiyonel nöron üretimidir. Erişkin beyninde nöron üretimi iki bölgeye sınırlıdır. Bunlardan biri hipokampus dentat girusundaki (DG) subgranüler bölge, diğeri lateral ventriküllerin subventriküler bölgesidir. Hipokampus DG'sinde üretilen yeni nöronlar fonksiyonel olarak olgun devrelere entegre olurlar, özellikle öğrenme ve hafıza fonksiyonu olmak üzere kognisyon ve emosyonel kontrole katkıda bulunurlar. Bu katkının nasıl gerçekleştiği hala açık değildir ve yoğun olarak araştırılan önemli bir konudur. Hipokampal nörogenezin hem yaşla birlikte hem yaşa bağlı hafızanın bozulması ile karakterize nörodejeneratif hastalıklarda azaldığı bilinmektedir. Hipokampal nörogenezin hafıza fonksiyonuna katkısını anlamak ve nörogenezi etkileyen faktörleri araştırmak bu nörodejeneratif hastalıklara karşı koruyucu ya da tedavi edici yaklaşımlar için önem kazanmıştır. Hipokampal DG'de üretilen yeni nöronların olgunlaşma süreçlerindeki elektrofizyolojik özellikleri (olgun nöronlara göre daha kolay uyarılabilir olmaları) sayesinde patern ayrımı (hipokampusa gelen benzer bilgilerin ayrı sunumları yapılarak örtüşmelerinin engellenmesi) yaparak spasyal ve epizodik hafıza fonksiyonuna katkıda bulundukları düşünülmektedir. Bu derlemede hipokampal nörogenezin nasıl oluştuğunu, nörogenez sürecine etkili fak...

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Section: Factors That Affect Adult Hippocampal Neurogenesissupporting

confidence: 75%

Section: Factors That Affect Adult Hippocampal Neurogenesissupporting

confidence: 68%

The Role of Adult Hippocampal Neurogenesis in Learning and Memory Function

Kaptan¹,

Üzüm²

2016

tnd

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“…There are some treatments for mental diseases such as autism or depression with antibiotics or probiotics like B. fragilis, Lactobacillus helveticus R0052, and Bifidobacterium longum R0175, to ameliorate anxiety-like, repetitive, and depressive behavior [76,77]. It is supportive that the development of gut microbiome contributes substantially to brain development like synaptogenesis and neuropsychiatric outcomes in later in life [78,79], establishment of appropriate stress responses and relevant behaviors and gut functions, such as motility which was demonstrated to be related with a reduced ganglionic density and size of myenteric plexus in patients with slow transit constipation. Evidently, exposure to an insulting stressor affects the gut microbiota and serum metabolomic profile such as cytokines (IL-6 and monocyte chemotactic protein-1) and tryptophan and correlates with changes in levels of pro-inflammatory cytokines and intestinal secretory IgA, which impacts intestinal homeostasis and increase the risk of inflammation-related dis- eases and dysbiosis [80,81].…”

Section: Relationship Between Stress and Gut Disorders Via Microbiomementioning

confidence: 99%

The Local Defender and Functional Mediator: Gut Microbiome

Yang¹,

Duan²

2018

Digestion

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Background: The gut microbiome has been developing and making adaption all the time, which is consistent with their host from the initial colonization at birth or earlier. Emerging evidence is showing that dysbiosis is involved in various diseases associated with immune, metabolism, infection, nervous system, social behaviors, and psychopathology, etc., maybe via modulating gut barrier, microbiome-gut-brain axis, or some metabolites like short-chain fatty acids (SCFAs). Summary: In the review, we will conclude the recent researches related to the influence of microbiome on local structure, function, regulation, metabolism of gut, and systematic modulation to the host, as well as some affective factors such as diet or antibiotics. Key Messages: It is a reasonable hypothesis that the balance of bioactive factors or cells and the opposites such as the regulatory T/helper T17 balance and interleukin (IL)-10/IL-17 balance plays a vital role in homeostasis of immunity system. Meanwhile, the link between gut microbiome and immune system via microbiota-derived metabolite SCFAs involved in multi-function of the host locally and systematically has been revealed. We hope to contribute to the microbiome-targeted treatment and prevention of some diseases.

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“…It is also negatively correlated to oxidative stress. Furthermore, BDNF has a role in regulating glucose metabolism in peripheral tissues and increase insulin sensitivity (25). Insulin function: There is a huge burden of research showing that long-term CR in lean and obese subjects improves insulin sensitivity, a mechanism by which CR may act to extend lifespan.…”

Section: Cognitive Impairment and Calorie Restrictionmentioning

confidence: 99%