Calorie Restriction, Longevity and Cognitive Function

Hanjani, Nazanin Asghari; Vafa, Mohammad Reza

doi:10.18869/acadpub.nfsr.3.1.1

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Aside from these observations, the results of three on-going CR studies on rhesus monkeys until now have demonstrated that aging CR-treated monkeys suffer less severe brain atrophy (hallmark of an aging brain) compared to the control fed AL. [ 22 ] In addition, it has been shown that CR can lead to up-regulation of brain-derived neurotrophic factor (BDNF) that is associated with neuronal plasticity and neurogenesis. [ 23 ]…”

Section: Introductionmentioning

confidence: 99%

Protein restriction, epigenetic diet, intermittent fasting as new approaches for preventing age-associated diseases

Hanjani

Vafa

2018

Int J Prev Med

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Data from epidemiological and experimental studies have shown that diet and eating patterns have a major role in the pathogenesis of many age-associated diseases. Since 1935, calorie restriction (CR) has been identified as one of the most effective nongenetic dietary interventions that can increase lifespan. It involves reducing calorie intake by about 20%–40% below ad libitum, without malnutrition. Restricting food intake has been observed to increase lifespan and prevent many age-associated diseases in rats, mice, and many other species. Understanding the metabolic, molecular, and cellular mechanisms involved in the anti-aging effects of CR can help us to find dietary interventions that can mimic its effects. Recently, different studies have shown that intermittent fasting, protein restriction, and an epigenetic diet can have similar effects to those of CR. These approaches were selected because it has been indicated that they act through a similar molecular pathway and also, are safe and effective in delaying or preventing diseases. In this review, we focus on the mechanistic pathway involved in CR. Then, we review the mimicking interventions through the mechanistic approach. For this purpose, we reviewed both animal and human articles, mainly available through the PubMed online database. We then selected the most relevant full texts which are summarized in this article.

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Section: Introductionmentioning

confidence: 99%