2009
DOI: 10.4238/vol8-4gmr662
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Lipid peroxidation and antioxidant capacity of G6PD-deficient patients with A-(202G>A) mutation

Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy in which reduced NADPH concentrations are not maintained, resulting in oxidative damage. We evaluated G6PD activity, oxidative stress levels and Trolox equivalent antioxidant capacity in individuals with the A-(202G>A) mutation for G6PD deficiency. Five hundred and forty-four peripheral blood samples were screened for G6PD deficiency; we also analyzed lipid peroxidation products measured as thiobarbituric acid reactive species and Trolox equ… Show more

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Cited by 12 publications
(9 citation statements)
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“…The addition of antioxidants to the extender has been shown to improve sperm viability of bovine semen (Krzyzosiak et al, 2000;Bilodeau et al, 2002). Vitamins A, C and E have been shown to be potent antioxidants (Breininger et al, 2005;Ondei et al, 2009). The inclusion of fruit juices from orange (Citrus sinensis), cucumber (Cucumis sativus) and pineapple (Ananas comosus) as constituents of semen extenders has recently been proved to improve the quality of stored spermatozoa (Daramola et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…The addition of antioxidants to the extender has been shown to improve sperm viability of bovine semen (Krzyzosiak et al, 2000;Bilodeau et al, 2002). Vitamins A, C and E have been shown to be potent antioxidants (Breininger et al, 2005;Ondei et al, 2009). The inclusion of fruit juices from orange (Citrus sinensis), cucumber (Cucumis sativus) and pineapple (Ananas comosus) as constituents of semen extenders has recently been proved to improve the quality of stored spermatozoa (Daramola et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Ascorbic acid is a well known non-enzymatic, water soluble natural antioxidant having capacity to reduce MDA concentrations and ROS damage by its chain breaking activity (Ho Lee, 1996;Fanaei et al, 2014). The findings in this present study coupled with better sperm viability parameters suggested that addition of vitamin C as potent antioxidant to semen extenders could reduce deleterious effects of membrane LPO on cryopreserved spermatozoa (Martin et al, 2002;Ondei et al, 2009).…”
Section: Discussionmentioning
confidence: 62%
“…In vitro studies suggested that the addition of some antioxidants to semen extender could improve motility and survival of spermatozoa (Molinia et al, 1994;Sánchez-Partida et al, 1997;Bilodeau et al, 2002). Vitamin C has been demonstrated as effective antioxidants (Ondei et al, 2009). Perusal of literatures however revealed no information on the effect of supplementation of vitamin C as exogenous antioxidant on sperm viability of WAD buck semen during cryopreservation.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, we suppose that alterations of NADH dependent enzymes activity may be also caused by the change in lipid peroxidation intensity [20] This relation is also discussed in other recent works [21] [22]. Thus, accumulation of nicotinamide coenzymes and rise of the second peak of the spectrum, respectively, may also be due to the intensification of lipid peroxidation process.…”
Section: Blood Plasma Fluorescence Studiesmentioning
confidence: 52%