Lipid-bound sialic acid in psoriasis and its correlation with disease severity

Shenoy, Chetana; Shantaram, Manjula; Sharanya, K; Shenoy, Manjunath Mala

doi:10.4103/2278-0521.151410

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…They noticed that elevated levels of CRP indicated the progression of the inflammatory response even in patients with mild psoriasis. The changes in the level of CP confirmed the results of Shenoy et al [ 239 ], who reported that the elevation of ceruloplasmin in psoriasis patients occurred in the acute phase of inflammatory response and could reflect its scavenging action on highly toxic hydroxyl radicals produced during the inflammatory process. The changes in the levels of aminotransferases were in agreement with the report by Razavizade et al [ 240 ], who discovered similar changes in psoriasis patients treated with metformin.…”

Section: Clinical Studiessupporting

confidence: 88%

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Соболев

Tchepourina

Korsunskaya

et al. 2022

IJMS

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The peroxisome proliferator-activated receptor PPAR-γ is one of three PPAR nuclear receptors that act as ligand-activated transcription factors. In immune cells, the skin, and other organs, PPAR-γ regulates lipid, glucose, and amino acid metabolism. The receptor translates nutritional, pharmacological, and metabolic stimuli into the changes in gene expression. The activation of PPAR-γ promotes cell differentiation, reduces the proliferation rate, and modulates the immune response. In the skin, PPARs also contribute to the functioning of the skin barrier. Since we know that the route from identification to the registration of drugs is long and expensive, PPAR-γ agonists already approved for other diseases may also represent a high interest for psoriasis. In this review, we discuss the role of PPAR-γ in the activation, differentiation, and proliferation of skin and immune cells affected by psoriasis and in contributing to the pathogenesis of the disease. We also evaluate whether the agonists of PPAR-γ may become one of the therapeutic options to suppress the inflammatory response in lesional psoriatic skin and decrease the influence of comorbidities associated with psoriasis.

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Section: Clinical Studiessupporting

confidence: 88%

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Соболев

Tchepourina

Korsunskaya

et al. 2022

IJMS

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“…Increased ceruloplasmin concentrations in psoriasis may indicate an acute phase-type response and/or it may reflect the scavenging action of ceruloplasmin which prevents the accumulation of highly toxic hydroxyl radicals produced during inflammation [36]. Payasvietal.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of action and effect of immune-modulating agents in the treatment of psoriasis

Elgharabawy

Ahmed

Al-Najjar

2017

Biomedicine & Pharmacotherapy

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“…Literature data show that early apoptosis is accompanied by a decrease in the amount of sialic acid in the cell membrane [50]. A lower level of this acid also indicates a reduction in inflammation, since sialic acid is considered a marker of inflammation in the body [51,52].…”

Section: Discussionmentioning

confidence: 99%

The Differential Effect of Cannabidiol on the Composition and Physicochemical Properties of Keratinocyte and Fibroblast Membranes from Psoriatic Patients and Healthy People

Szachowicz-Petelska

Łuczaj

Wroński³

et al. 2021

Membranes

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The development of psoriasis is accompanied by oxidative stress, which can modify the components of skin cells. Therefore, the aim of this study was to evaluate the effect of cannabidiol (CBD), an antioxidant and anti-inflammatory phytocannabinoid, on the composition and physicochemical properties of the membranes of healthy and psoriatic keratinocytes and fibroblasts exposed to ultraviolet A (UVA) and ultraviolet B (UVB) radiation. In psoriasis-altered cells, decreased levels of the main groups of phospholipids and increased levels of sialic acid and malondialdehyde (MDA), a lipid peroxidation product, as well as negative charge of cell membranes compared to non-diseased cells, were found. On the other hand, UVA/B radiation increased the levels of phospholipids and MDA in both groups of cells. Moreover, psoriatic cells were characterized by lower levels of sialic acid and negative charge of cell membranes, while non-diseased cells showed the opposite response. The CBD treatment intensified some of the changes (phospholipid content and membrane charge) caused by the radiation of psoriatic cells, while it prevented these changes in the cells of healthy people. The results of this study indicate that CBD can prevent structural and functional changes to the membranes of healthy skin cells during phototherapy for psoriasis.

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Lipid-bound sialic acid in psoriasis and its correlation with disease severity

Cited by 5 publications

References 12 publications

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Mechanism of action and effect of immune-modulating agents in the treatment of psoriasis

The Differential Effect of Cannabidiol on the Composition and Physicochemical Properties of Keratinocyte and Fibroblast Membranes from Psoriatic Patients and Healthy People

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