Mechanism of action and effect of immune-modulating agents in the treatment of psoriasis

Elgharabawy, Rehab M.; Ahmed, Amira; Al-Najjar, Amal Hassan

doi:10.1016/j.biopha.2016.11.105

Cited by 22 publications

(25 citation statements)

References 31 publications

(31 reference statements)

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“…[ 19 ] El-Gharabawy et al reported the activation of PPAR-γ receptors by pioglitazone results in reduced formation of the proinflammatory cytokines and infiltration of the inflammatory cells, indicating the beneficial effects of pioglitazone in treatment of psoriasis. [ 8 ] Moreover, our meta-analysis of 6 randomized trials indicated that pioglitazone has a beneficial effect in PsV, as reflected by the improved PASI and treatment success rate. Some studies implied the rosiglitazone was related to an increased risk of cardiovascular death and heart attack, but pioglitazone seems not to share this risk.…”

Section: Discussionmentioning

confidence: 98%

“…Pioglitazone is a representative of the thiazolidinedoniones (TZDs) drug known in diabetes and dyslipidemia, with no serious side effects in short-term use. [ 7 , 8 ] It works by binding to the proliferator-activated receptors (PPARs) that regulate carbohydrate and lipid metabolism. [ 9 ] PPARs are expressed on epidermal keratinocytes, and activation of these receptors have been shown to inhibit the proliferation of psoriatic human keratinocytes in vitro.…”

Section: Introductionmentioning

confidence: 99%

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The efficacy and safety of pioglitazone in psoriasis vulgaris

Chen

Lei

et al. 2020

Medicine

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of pioglitazone in psoriasis vulgaris

Chen

Lei

et al. 2020

Medicine

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“…3 Furthermore, treatment groups receiving either pioglitazone or metformin experienced an overall significant decrease in CD4+, which are involved in the initiation and maintenance of the pathogenic role of psoriasis. 62…”

Section: Jo00820mentioning

confidence: 99%

Oral Metformin for Treating Dermatological Diseases: A Systematic Review

Sung¹,

Chao²,

Lee³

et al. 2020

JDD

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Introduction:Metformin is an antihyperglycemic medication most commonly used to treat type II Diabetes Mellitus with promising off-label application for the treatment of hidradenitis suppurativa, psoriasis, acne, acanthosis nigricans, and hirsutism. Objective: To comprehensively assess evidence regarding the use of metformin for treating primary cutaneous disorders. Materials and Methods: A systematic literature search was conducted through PubMed, Cochrane, Web of Science, and CINAHL to identify the role of metformin in primary skin disease. Results: Sixty-four studies met inclusion criteria. Metformin demonstrates promising clinical response and favorable safety profile for treatment of HS, with most patients experiencing a decrease in frequency or severity of HS flares, and some experiencing full resolution of HS lesions. Patients with psoriasis treated with metformin experienced quantifiable clinical responses. Application of metformin on polycystic ovarian disease (PCOS) related acne, acanthosis nigricans, and hirsutism yielded mixed clinical results. No serious adverse effects were reported. Conclusion: Metformin is safe and efficacious and may be considered as an adjunctive therapy for the treatment of psoriasis and hidradenitis suppurativa in addition to first line therapies as well as PCOS related acne, acanthosis nigricans, and hirsutism.

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“…In addition, many inflammatory respiratory tract diseases were reported to be related with abnormal MPO/CAT ratios [14]. CP also shows anti-oxidant-like ferroxidase activity (FOX), it plays an important role as free oxygen radical scavenger [15]. The ceruloplasmin level may be an indicator related with the inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

Trace elements and oxidative stress status in patients with psoriasis

Kirmit

Kader

Aksoy

et al. 2020

pdia

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Introduction: Psoriasis is a common, inflammatory skin disease of which etiopathogenesis is still not explained clearly, however in which trace elements and oxidative stress are considered to play a role. Aim: To evaluate the serum trace element and oxidative stress levels in patients diagnosed with psoriasis. Material and methods: A total of 87 psoriasis patients and 60 healthy subjects were included in the study. Serum sodium (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), selenium (Se), zinc (Zn), copper (Cu) levels, oxidative stress parameters, ischemia-modified albumin (IMA), catalase (CAT), myeloperoxidase (MPO) and ferroxidase (FOX) activity and an inflammatory marker, C-reactive protein (CRP), were examined in all participants. Results: IMA, IMA/Albumin (IMA/Alb), CAT, Cu, FOX and CRP levels were found to be significantly higher; Se, Zn and albumin levels were significantly lower in the patient group as compared to the control group. No significant difference was found between groups with regard to Na, K, Ca, P, Mg, Fe and MPO levels. Conclusions: Some trace element levels and oxidant-antioxidant balance were changed in psoriasis patients.

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Mechanism of action and effect of immune-modulating agents in the treatment of psoriasis

Cited by 22 publications

References 31 publications

The efficacy and safety of pioglitazone in psoriasis vulgaris

The efficacy and safety of pioglitazone in psoriasis vulgaris

Oral Metformin for Treating Dermatological Diseases: A Systematic Review

Trace elements and oxidative stress status in patients with psoriasis

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