Dyslipidemias are one of the common metabolic disorders. A link between dermatological disorders like psoriasis and dyslipidemia has been established in the recent past. Many dermatological disorders could have a systemic inflammatory component which explains such association. Chronic inflammatory dermatological disorders could also have other metabolic imbalances that may contribute to dyslipidemia. Presence of such abnormal metabolism may justify routine screening of these disorders for associated dyslipidemia and other metabolic abnormalities and early treatment of such comorbidities to improve quality of life. Some of the drugs used by dermatologists such as retinoids are also likely to be a cause of dyslipidemia. Hence, it is imperative that the dermatologists obtain scientific knowledge on the underlying mechanisms involved in dyslipidemia and understand when to intervene with therapies. A systematic review of the English language literature was done by using Google Scholar and PubMed. In this review, attempts are made to list the dermatological disorders associated with dyslipidemia; to simplify the understanding of underlying mechanisms; and to give a brief idea about the interventions.
intention to treat.RESULTS: The median age of the patients was 33 years (range, 24-41 years). 77.8% of the patients were under hormonal therapy that was discontinued. 17 patients interrupted the research of pregnancy because of change of partner, health problems or change of plans. 25 patients (27.8%) conceived spontaneously; the median time required to conceive was 10 months (range, 2-32 months). 17 patients (18.8%) conceived by intrauterine insemination or by in vitro fertilization; the median time required to conceive was 21 months (range, 9-46 months). The total pregnancy rate in the study population was 46.7% (42/90; 95% C.I., 36.1-57.5%) after a median follow up of 28.2 months (range, 2-70 months). The pregnancy outcomes of the 42 women that conceived were evaluated: 54.8% (23/42; 95% C.I., 38.7-70.2%) of the patients had a vaginal delivery; 16 patients had a cesarean section (38.1%; 95% C.I., 23.6-54.4%) and 3 women had a miscarriage (7.14%; 95% C.I., 1.5-19.5%). After the first pregnancy, there were 4 conceptions among the 10 patients who tried to conceive again.CONCLUSIONS: Patients with colorectal endometriosis have a spontaneous pregnancy rate of about 28% and a total pregnancy rate of about 47%. Patients with colorectal endometriosis should be informed on the possibility to conceive either spontaneously or by assisted reproductive technologies without undergoing surgical excision of endometriosis.
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