Skin tags are not merely cosmetic: A study on its association with metabolic syndrome

Shenoy, Chetana; Shenoy, Manjunath Mala; Krishna, Sowmyashree; Pinto, Malcolm

doi:10.4103/2278-344x.173882

Cited by 5 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prevalence of metabolic syndrome was significantly higher in patients with skin tags compared to controls, similar to the observation by Shenoy et al and Safoury et al [1112]…”

Section: Discussionsupporting

confidence: 88%

“…In the univariate analysis of components of metabolic syndrome, higher waist circumference, high TGs, and low HDL were observed among cases compared to controls ( P < 0.05), similar to Shah et al , Safoury et al , and Agamia et al [101113] Although mean fasting plasma glucose was higher in cases when compared to controls, the difference was not statistically significant which is in accordance with the study by Shenoy et al , Maluki et al , and Wali et al [121415] However, other studies have found significantly higher fasting plasma glucose in cases compared to controls at significant level. [10111316] The prevalence of hypertension was significantly higher in patients with skin tags, in accordance with the results by Sari et al and Senel et al ; however, Safoury et al , did not observe such difference.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Association of skin tag with metabolic syndrome and its components: A case–control study from Eastern India

Tripathy

Singh

Kar

2019

Indian Dermatol Online J

View full text Add to dashboard Cite

Background: Skin tags are benign polyps, usually found in the natural folds of the skin. Some studies have found an association of skin tags with obesity, diabetes, hypertension, and atherogenic lipid profile. Metabolic syndrome refers to co-occurrence of these cardiovascular risk factors such as insulin resistance, obesity, dyslipidemia, and hypertension. Aims and Objectives: To find out any possible association of skin tags with metabolic syndrome and its components. Materials and Methods: A case–control study was conducted including 140 participants. Seventy patients with skin tags were considered cases, and 70 age- and sex-matched patients without skin tags were considered as controls. Various anthropometric and biochemical parameters were compared and analyzed between the two groups. Results: Univariate analysis revealed significantly higher waist circumference, high triglyceride, and low high-density lipoproteins (HDLs) in cases compared to controls. The prevalence of diabetes, hypertension, and metabolic syndrome was significantly higher in patients with skin tags, and risk of developing metabolic syndrome was 11.13 times higher in cases compared to controls ( P < 0.05). Multivariate logistic regression analysis revealed high waist circumference and low serum HDL had significant association with skin tags. Conclusion: Risk of development of metabolic syndrome is significantly higher in patients with skin tags. Among the various components of metabolic syndrome, only high waist circumference and low serum HDLs are significantly associated with skin tags.

show abstract

“…Prevalence of metabolic syndrome was significantly higher in patients with skin tags compared to controls, similar to the observation by Shenoy et al and Safoury et al [1112]…”

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Association of skin tag with metabolic syndrome and its components: A case–control study from Eastern India

Tripathy

Singh

Kar

2019

Indian Dermatol Online J

View full text Add to dashboard Cite

show abstract

“…16,25 In the present study, the prevalence of hypertension was significantly higher in patients with skin tags which is comparable with the results by Sari et al and Senel et al 25,26 However, Safoury et al, did not observe such difference. 23 The lipid profile status in the study showed significantly higher cholesterol and TG levels and lower HDL levels in cases compared to controls, similar to the observations made by Safoury et al, Sari et al, and Senel et al 23,26,25 Rasi et al found a positive correlation between the total number of skin tags and the mean fasting plasma glucose. 27 Not found any significant association between various skin tag characteristics such as colour, localization, and length with metabolic syndrome on statistical analysis.…”

Section: Discussionsupporting

confidence: 87%

“…17,21 Among the various components of metabolic syndrome, increased waist circumference and hypertriglyceridemia were significantly found to be associated with skin tags which are in concordance to the results obtained by Shenoy et al, Agmia et al and Safoury et al as in this study found significant association of skin tags with high triglyceride levels and low HDL levels. 9,22,23 Observed higher waist circumference, high Triglycerides, and low HDL among cases compared to controls (P<0.05). Similar observation was made by Shah et al, Safoury et al, and Agamia et al 16,23,9 The mean fasting plasma glucose although was higher in cases when compared to controls, the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 93%

“…9,22,23 Observed higher waist circumference, high Triglycerides, and low HDL among cases compared to controls (P<0.05). Similar observation was made by Shah et al, Safoury et al, and Agamia et al 16,23,9 The mean fasting plasma glucose although was higher in cases when compared to controls, the difference was not statistically significant. These results are comparable to those of Shenoy et al, Maluki et al 22,24 However, other studies have found significantly higher fasting plasma glucose in cases compared to controls at significant level.…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Metabolic syndrome in south Indian population with skin tags: a hospital-based case control study

Naidu

Baddireddy

2020

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Metabolic syndrome is a constellation of several clinical and laboratory cardiovascular risk factors that have been linked with numerous medical and dermatologic conditions. Recent evidence suggests a strong association between skin tags and insulin resistance and obesity, yet there is a paucity of data on relation of skin tags with metabolic syndrome as a whole. Aim of the study was to evaluate the strength of association between skin tags and metabolic syndrome.Methods: 70 patients with skin tags and an equal number of age and gender matched controls were enrolled in a hospital-based case control study. Anthropometric measures, blood pressure, fasting glucose, high density lipoprotein cholesterol and triglycerides were measured. Metabolic syndrome was diagnosed by the presence of 3 or more of the south Asian modified national cholesterol education program’s adult panel III criteria. Statistical analysis was performed using chi square test, and odds ratio was calculated. P≤0.05 were considered significant.Results: Metabolic syndrome was significantly more common in patients with skin tags than in controls (70% vs. 26%, p<0.001). Triglycerides and waist circumference values were significantly increased in cases as compared to controls (p<0.05). There was no statistically significant difference in the high-density lipoprotein levels, fasting blood glucose levels and presence of hypertension among cases and controls.Conclusion: Skin tags when present in multiple could be an early warning sign for Metabolic syndrome. They serve a cutaneous marker to initiate early detection and intervention of at-risk patients for cardiovascular disorders.

show abstract

The interrelation of seborrheic dermatitis with facial skin lesions with metabolic syndrome and diabetes mellitus

Molodykh

Araviiskaia

Sokolovskiy

2021

Russian Journal of Skin and Venereal Diseases

View full text Add to dashboard Cite

BACKGROUND: In recent decades, interest in the role of metabolic syndrome and its impact on dermatological pathology has been steadily increasing. One of the pathogenetic components of the metabolic syndrome is inflammation, and many pro-inflammatory factors play a crucial role in the development of this disease. However, the interrelation between the metabolic syndrome and facial skin lesions in seborrheic dermatitis remains not fully understood. AIMS: To identify a possible association of seborrheic dermatitis with the involvement of the skin of the face with metabolic syndrome and diabetes mellitus. MATERIAL AND METHODS: The study included 45 patients with seborrheic dermatitis, divided into 3 groups (patients with seborrheic dermatitis, patients with seborrheic dermatitis and metabolic syndrome, and patients with seborrheic dermatitis, metabolic syndrome and diabetes mellitus). The severity of the disease was determined by the lesion area and the seborrheic dermatitis severity index (SEDASI). The metabolic syndrome was diagnosed based on the NCEP ATP III criteria. RESULTS: When assessing the severity of seborrheic dermatitis of the face and scalp, it was found that in group 1, a mild degree was observed in all (100%) patients. In group 2, 7 (46.7%) patients had moderate lesion and 8 (53.3%) patients had severe lesion. In group 3, a moderate degree of the disease was observed in 10 (82%) patients and severe in 5 (18%) patients. A positive correlation was found between the indices of metabolic syndrome and the severity of seborrheic dermatitis with facial skin lesions. A significant correlation was shown between the level of triglycerides and the number of anatomical zones involved in the process (r=0.74; p 0.01). In patients of groups 2 and 3, a direct interrelation was established between low levels of HDL, high levels of LDL and the severity of SD of the face (r=0.379; p=0.76), (r=0.321, p=0.037). CONCLUSION: The severity of the course and spread of seborrheic dermatitis on the face can serve as a diagnostic marker of metabolic syndrome and diabetes mellitus. An increase in the level of LDL and triglycerides, a decrease in the level of HDL, and insulin resistance are associated with a severe course of seborrheic dermatitis in a person, playing a significant role in the pathogenesis of the disease.

show abstract

Skin tags are not merely cosmetic: A study on its association with metabolic syndrome

Cited by 5 publications

References 0 publications

Association of skin tag with metabolic syndrome and its components: A case–control study from Eastern India

Association of skin tag with metabolic syndrome and its components: A case–control study from Eastern India

Metabolic syndrome in south Indian population with skin tags: a hospital-based case control study

The interrelation of seborrheic dermatitis with facial skin lesions with metabolic syndrome and diabetes mellitus

Contact Info

Product

Resources

About