Association of skin tag with metabolic syndrome and its components: A case–control study from Eastern India

Abstract

Background: Skin tags are benign polyps, usually found in the natural folds of the skin. Some studies have found an association of skin tags with obesity, diabetes, hypertension, and atherogenic lipid profile. Metabolic syndrome refers to co-occurrence of these cardiovascular risk factors such as insulin resistance, obesity, dyslipidemia, and hypertension. Aims and Objectives: To find out any possible association of skin tags with metabolic syndrome and its components. Materials and Methods: A case–control study was conducted including 140 participants. Seventy patients with skin tags were considered cases, and 70 age- and sex-matched patients without skin tags were considered as controls. Various anthropometric and biochemical parameters were compared and analyzed between the two groups. Results: Univariate analysis revealed significantly higher waist circumference, high triglyceride, and low high-density lipoproteins (HDLs) in cases compared to controls. The prevalence of diabetes, hypertension, and metabolic syndrome was significantly higher in patients with skin tags, and risk of developing metabolic syndrome was 11.13 times higher in cases compared to controls ( P < 0.05). Multivariate logistic regression analysis revealed high waist circumference and low serum HDL had significant association with skin tags. Conclusion: Risk of development of metabolic syndrome is significantly higher in patients with skin tags. Among the various components of metabolic syndrome, only high waist circumference and low serum HDLs are significantly associated with skin tags.

Presence of Cutaneous Signs of Insulin Resistance with Central Obesity (CO-CSIR) in Asian Indians is a sensitive physical sign of Metabolic Syndrome (MetS)

“…Several previous studies from India have investigated association between these cutaneous signs of IR in isolation with different facets of MetS like anthropometric measures of obesity (i.e., BMI [32], waist circumference [37,38], W:H ratio), HOMA-IR [29,30,31,33], lipid parameters, diabetes and other diseases clustering with MetS [34,35,36]. They all nd an association between these cutaneous signs and the facets of MetS they investigated.…”

Pólipo fibroepitelial vulvar: una serie de casos

“…La etiología de los PFE no ha sido completamente estudiada, pero se ha encontrado una asociación con la presencia de anormalidades metabólicas, como obesidad, diabetes mellitus II, resistencia a la insulina, dislipidemias, hiper- tensión y lipoproteínas de alta densidad (HDL) bajas (6) . Sin embargo, ninguna de nuestras pacientes presentó alteraciones metabólicas.…”

Stability Profile and Clinical Evaluation of an Innovative Hydrogel Containing Polymeric Micelles as Drug Delivery Systems with Oregano Essential Oil against Fibroepithelial Polyps

“…IGF-1 stimulates fibroblast proliferation, which further cascades a hyperplasia of keratinocytes with the occurrence of hyperkeratosis and papillomatosis [ 13 , 14 ]. FPs are also strongly associated with a certain risk of development of metabolic syndrome characterized by the co-occurrence of dyslipidemia, hypertension, obesity, and insulin resistance, specifically in the case of patients with low HDL and high waist circumference [ 15 , 16 ].…”