Atherogenic lipid profile in psoriasis: Correlation with severity and duration of the disease

Impact of psoriasis on serum lipid profile, CRP, ADA: A controlled study of 25 patients

“…Psoriasis is a chronic inflammatory dermatological condition characterized by increased T-helper-1 and T-helper-17 cell activity. 2 It has been suggested that psoriasis, like atherosclerosis, could have autoimmunity to play a role in its pathogenesis. 2 The cytokines implicated in psoriases such as IL-6, IL-8, INF-γ, IL-1, and IL-17 are also implicated in the generation of pro-atheromatous abnormalities.…”

“…2 It has been suggested that psoriasis, like atherosclerosis, could have autoimmunity to play a role in its pathogenesis. 2 The cytokines implicated in psoriases such as IL-6, IL-8, INF-γ, IL-1, and IL-17 are also implicated in the generation of pro-atheromatous abnormalities. 2 Serum adenosine deaminase (S. ADA) is an enzyme involved in purine metabolism.…”

“…Its prevalence and exacerbations/remissions are affected by multiple environmental, immune hormonal and mental factors besides, alcohol and drug abuse. 2 Traditionally psoriasis has been considered a dermatologic disease, but the contemporary medical evidence supports that psoriasis is actually a multisystem disease. It has been associated with an increased morbidity and mortality from cardiovascular events, especially those with a severe and long duration of psoriatic skin lesions.…”

“…It has been associated with an increased morbidity and mortality from cardiovascular events, especially those with a severe and long duration of psoriatic skin lesions. 2 Multiple factors like pro-atherogenic lipoprotein profile which includes hypertriglyceridemia raised plasma concentrations of LDL, and a lowered HDL concentration have been reported to be associated with psoriasis. 2 There is a complex network of inflammatory and immune cells, cytokines, chemokines and growth factors, all of which interact with one another to initiate a cascade of inflammatory events resulting in T-cell infiltration in the epidermis and dermis.…”

“…2 Multiple factors like pro-atherogenic lipoprotein profile which includes hypertriglyceridemia raised plasma concentrations of LDL, and a lowered HDL concentration have been reported to be associated with psoriasis. 2 There is a complex network of inflammatory and immune cells, cytokines, chemokines and growth factors, all of which interact with one another to initiate a cascade of inflammatory events resulting in T-cell infiltration in the epidermis and dermis. 3 Recently the concept of "psoriatic march" has been proposed, in which chronic cutaneous inflammation in psoriasis leads to systemic inflammation, which, in conjunction with increased oxidative stress triggers a cascade of events including oxidative stress, dyslipidemia, endothelial dysfunction and insulin resistance which increases the risk of cardiovascular complications in these patients.…”