Impact of psoriasis on serum lipid profile, CRP, ADA: A controlled study of 25 patients

Abstract

Introduction: Psoriasis is a chronic disorder with certain systemic compounds. It has been associated with increase in morbidity and mortality from cardiovascular events especially in chronic cases. Aims and Objectives: To compare the levels of CRP, S.ADA and S. Lipid profile among psoriatic patients and controls. Materials and Methods: This is a cross sectional case control study conducted in department of dermatology for a period of 6 months in a teaching institute of Gujarat. Cases included patients of psoriasis attending skin OPD. Controls were taken from health check-up scheme of our hospital with minimal confounding factor. CRP, S.ADA and S. Lipid profile were assessed in both groups. Statistical Analysis: We applied Unpaired T-test for statistical analysis and p value < 0.05 was considered significant. Results: Patient and control group consisted of 25 subjects each. Serum CRP, serum cholesterol and serum TG levels were found to be more significantly elevated in cases when compared to controls with p-value (by unpaired t test) of 0.001, 0.026 and 0.044 respectively. Serum ADA, LDL, VLDL was high among cases when compared to controls but were not statistically significant. (p>0.05). Conclusion: patients of psoriasis have to be evaluated for risk factors of atherosclerosis like Serum lipid profile, CRP.