Light emitting diode mediated photobiomodulation therapy improves orthodontic tooth movement and miniscrew stability: A randomized controlled clinical trial

Ekizer, Abdullah; Türker, Gökhan; Uysal, Tancan; Güray, Enis; Taşdemir, Zekeriya

doi:10.1002/lsm.22516

Cited by 54 publications

(73 citation statements)

References 37 publications

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“…21,22 PBMT: accelerated rates of tooth movement PubMed was used to identify randomized, controlled clinical trials during the past 5 years; published articles provide a positive relationship between PBMT and expedited/accelerated tooth movement during appliance therapy. [23][24][25][26] Keywords used were photobiomodulation, low-level laser therapy, ''lowlevel light therapy,'' orthodontics, tooth movement, and randomized clinical trial ‡5 years.…”

Section: Clinical Applications Of Pbmt In Orthodonticsmentioning

confidence: 99%

Systematic Review of Orthodontic Treatment Management with Photobiomodulation Therapy

Cronshaw

Parker

Anagnostaki

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Objective: This systematic review of published research evaluates the parameters and reported outcomes in photobiomodulation therapies (PBMTs) used in management of pain and accelerated tooth movement during orthodontic treatment. Background: Consequent to positive in vitro and animal studies, there has been considerable interest in the potential applications of PBMT to ameliorate pain and to accelerate orthodontic tooth movement. Due to the lack of consistency of wavelengths and parameters applied, there is as yet no consensus in respect of guidance for clinical use. Within the limitations of the reported literature, a digest of key outcomes and parameters is presented here to assist researchers and interested clinicians. Materials and methods: Search engines, PubMed, Google Scholar, and Cochrane, were applied to identify clinical investigations into the potential benefits of PBMTs in orthodontic management. Keywords used were ''low-level laser therapy,'' ''low-level light therapy,'' ''photobiomodulation,'' ''orthodontics,'' ''pain,'' ''tooth movement,'' and ''randomized clinical trial ‡5 years.'' A total of 35 articles were identified, covering the 5-year period January 2013 to December 2018. Only human clinical trials were considered. Seventeen articles were included in this investigation and the reported parameters and outcomes were assessed and presented for comparison. Results: Seven of nine studies supported the effectiveness of PBMT to reduce or prevent pain. There was no consensus on choice of wavelength and a range of parameters were found beneficial. Of the seven tooth movement studies included, four of the seven were positive, of which two used a home-use light-emitting diode (LED) device, as opposed to a clinician-applied laser. A variety of wavelengths and parameters were found to be effective in accelerating tooth movement in the range of 20-40% compared with control. Conclusions: Due to a lack of consistency in approach, further studies are required to achieve a high level of acceptance. The clinical logistics associated with frequent applications supports the concept of patient home delivery use of LED devices, although there are insufficient studies at present to make an evidence-based determination of this type of appliance. To gain more general professional acceptance of the use of PBMT in orthodontics, a continued effort to extend the number of quality human clinical trials is required. Based on the current evidence base, further positive onward progression can be regarded as inevitable.

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Section: Clinical Applications Of Pbmt In Orthodonticsmentioning

confidence: 99%

Systematic Review of Orthodontic Treatment Management with Photobiomodulation Therapy

Cronshaw

Parker

Anagnostaki

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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“…Eight studies were identified based on our inclusion criteria (Table 3). [34][35][36][37][38][39] Evidence-based conclusion and recommendation. Improving orthodontic anchorage can be achieved by placing mini-implants or miniscrews in the alveolar bone.…”

Section: Does Photobiomodulation Irradiation Influence Mini-ti Implanmentioning

confidence: 99%

“…However, the improved stability results (measured by Periotest) reported in Osman et al's study were not statistically significant. 38,39,41 They have also evaluated the inflammatory markers in the peri-implant crevicular fluid (PGF) and concluded that since LLLT modulates the initial inflammation after the insertion of mini-implants, it seems that it is possible to increase the mini-implant success prognosis and decrease patient discomfort with adjunctive photobiomodulation.…”

Section: Does Photobiomodulation Irradiation Influence Mini-ti Implanmentioning

confidence: 99%

Photobiomodulation in Periodontology and Implant Dentistry: Part 2

Gholami

Asefi

Hooshyarfard

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Part 1 of this article can be located at www.liebertpub.com/doi/10. 1089/photob.2019.4710.) Objective: Finding evidence-based treatment strategies for low-level light therapy and the correct incorporation of these treatment methods in the clinical practice of periodontics. Background: Photobiomodulation has been shown to have biostimulatory, anti-inflammatory, and analgesic effects that can be beneficial in periodontal and dental implant treatment procedures. Methods: In this review, we have addressed some clinical questions regarding the potential clinical application of low-level light irradiation and its photobobiomodulatory effects in periodontology and implantology. The literature was searched for in vivo (animal or clinical) articles written in English in four electronic databases of PubMed, Scopus, Google Scholar, and Cochrane Library until April 2019. Only studies with low irradiation doses without any thermal effects used only for their photobiomodulatory purposes were included. Results: We were able to find relevant studies for all of our questions, and positive effects for the application of light therapy were reported in most of the studies. However, there is still a great deal of heterogeneity in terms of study designs and most importantly in light irradiation devices and the parameters used. Due to this issue, it was not possible to reach specific evidence-based irradiation protocols for the questions addressed in this review. Conclusions: Based on our search results, an obvious positive effect of low-level light therapy on stimulation of healing of periodontal soft and hard tissues and reduction of inflammation can be seen. Future well-designed randomized control studies with the same irradiation settings and systematic reviews evaluating the studies found on the questions mentioned are necessary to reach evidence-based recommendations.

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“…It has also been reported that laser coherent light (laser) and non-coherent light (LED) produce similar biological effects (7); however, infrared LEDs have not been well investigated. Previous clinical studies revealed that LED significantly increased the amount of tooth movement and reduced pain in patients (8)(9)(10). It reduces number of osteoclasts in the periodontal ligament (11) and accelerate tooth movement in rats (12).…”

Section: Introductionmentioning

confidence: 98%

Infrared Light-Emitting Diode (LED) Effects on Orthodontic Tooth Movement

et al. 2019

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The present study aimed to analyze the effect of LED phototherapy on the presence of hyalinization and root resorption during orthodontic tooth movement (OTM) in rats and to measure the amount of tooth movement. Eighty rats were allocated into two groups: LED and control (CON), where the LED rats were irradiated with infrared LED (850 nm, 30 mW) for 5 min during the first five days of OTM and where controls were not irradiated. Both groups were subdivided into four subgroups (n=10) according to the date of euthanasia (4, 7, 14 and 21 days). Five out of ten LED21 and five of ten CON21 rats were submitted to micro-computed tomography (μCT); μCT scans were taken on days 0, 7, 14 and 21. For histological study, maxillae were processed to light microscopy using Hematoxylin-Eosin (HE) and Tartrate-Resistant Acid Phosphatase (TRAP) histochemistry. The amount of tooth movement did not differ between LED and CON. Hyalinization was observed at the pressure areas in both groups, and it did not show a statistically significant difference between the groups. Root resorption was also observed in both groups after 7 days and it did not represent any differences between the two groups. LED phototherapy was not able to increase the amount of OTM. Similar characteristics of hyalinization and root resorption were observed in both groups.

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Light emitting diode mediated photobiomodulation therapy improves orthodontic tooth movement and miniscrew stability: A randomized controlled clinical trial

Abstract: LPT had the potential of accelerating orthodontic tooth movement and had a positive effect on miniscrew stability. Lasers Surg. Med. 48:936-943, 2016. © 2016 Wiley Periodicals, Inc.

Cited by 54 publications

References 37 publications

Systematic Review of Orthodontic Treatment Management with Photobiomodulation Therapy

Systematic Review of Orthodontic Treatment Management with Photobiomodulation Therapy

Photobiomodulation in Periodontology and Implant Dentistry: Part 2

Infrared Light-Emitting Diode (LED) Effects on Orthodontic Tooth Movement

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