Laryngeal mycosis fungoides

Abstract

Mycosis fungoides presented as a tumor of the arytenoid cartilage and epiglottis of the larynx of an 80-year-old female. The tumor was initially interpreted as an undifferentiated small cell malignant neoplasm and treated with radiation. Two years later the patient developed widespread cutaneous involvement with mycosis fungoides, including mycosis fungoides bullosum. The mycosis fungoides progressed to death over the next two years. At autopsy widespread visceral involvement was present. The larynx was extensively infiltrated with mycosis fungoides, and the histology was similar to the original laryngeal biopsy. Although mycosis fungoides is generally thought of as a cutaneous disease, it may rarely present in a squamous epithelium-lined organ other than the skin.

Mycosis fungoides bullosa simulating pyoderma gangrenosum

“… 7 , 15 Subepidermal bulla formation were reported in seven cases. 2 , 3 , 8 , 17–20 Subepidermal bulla formation was found in the typical MF bullosa lesions which occurred in the trunk of our patient. The biopsy of the tumorous lesion at her left ankle, however, revealed intraepidermal bulla formation.…”

“…Fibrin deposits were also found in venular walls and around dermal collagen. 20 Ead also reported deposition of IgG in the dermis in the patient with MF bullosa; however, no details were given in relation to the specific location of such deposits. 21 Interestingly, indirect immunofluorescence revealed intercellular antibodies occurring at a titre of 1 : 320 in the same patient reported by Ead, while DIF examination showed no intercellular staining in the epidermis.…”

Hoarseness as a presentation of mycosis fungoides infiltrating the larynx

“…Hood et al 5 describe a patient with dysphagia and a tumour of the laryngeal surface of the epiglottis and aryepiglottic fold. Biopsy of the tumour was read as undifferentiated malignant neoplasm, and symptoms cleared with radiation therapy.…”

A Rare Case of Mycosis Fungoides in the Oral Cavity and Small Intestine Complicated by Perforation

“…There have been reports of MF cases throughout the GI tract, including the small intestine (Table 1) [3, 4, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43]. Briefly, there have been 67 cases of GI MF in the reported literature.…”