Mycosis fungoides bullosa simulating pyoderma gangrenosum

Ho, Kenneth; Browne, Andrew; Fitzgibbons, John F.; Carney, Desmond N.; Powell, Frank C.

doi:10.1046/j.1365-2133.2000.03253.x

Cited by 27 publications

(15 citation statements)

References 21 publications

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“…Predilection sites are the trunk and limbs. Vesicles and blisters usually arise in typical plaques and tumours but also in normal-appearing skin [2,4]. …”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides bullosa: a case report and review of the literature

2010

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IntroductionMycosis fungoides, the most common type of cutaneous T-cell lymphoma, can manifest in a variety of clinical and histological forms. Bulla formation is an uncommon finding in mycosis fungoides and only approximately 20 cases have been reported in the literature.Case presentationWe present a case of rapidly progressive mycosis fungoides in a 68-year-old Caucasian man who initially presented with erythematous plaques characterised by blister formation.ConclusionAlthough mycosis fungoides bullosa is extremely rare, it has to be regarded as an important clinical subtype of cutaneous T-cell lymphoma. Mycosis fungoides bullosa represents a particularly aggressive form of mycosis fungoides and is associated with a poor prognosis. The rapid disease progression in our patient confirms bulla formation as an adverse prognostic sign in cutaneous T-cell lymphoma.

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“…Predilection sites are the trunk and limbs. Vesicles and blisters usually arise in typical plaques and tumours but also in normal-appearing skin [2,4]. …”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides bullosa: a case report and review of the literature

2010

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“…Histopathologically there may be either intraepidermal or subepidermal bulla formation with negative direct immunofluorescence; aggregates of atypical lymphoid cells must be seen in all MF with PG-like lesions. 20,21 On the contrary, however, no atypical cells are found in PG associated with myeloproliferative disorders. 22 The main differential diagnosis is primary cutaneous CD8positive epidermotropic cytotoxic T-cell lymphoma.…”

Section: Discussionmentioning

confidence: 98%

“…20 MF bullosa simulating PG was recently reported by Ho et al . 21 It presents as flaccid or tense bullae arising on erythematous plaques or tumours. Histopathologically there may be either intraepidermal or subepidermal bulla formation with negative direct immunofluorescence; aggregates of atypical lymphoid cells must be seen in all MF with PG-like lesions.…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides presenting with extensive pyoderma gangrenosum‐like ulcers

Carbia

Hochman

Chain

et al. 2002

Acad Dermatol Venereol

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Mycosis fungoides (MF) may present with atypical clinical manifestations. Usually it mimics various chronic dermatoses, with the appearance of ulcers during the tumour stage. Infrequently, cutaneous ulcers are the main or initial sign of lymphoma. We report the case of a man who presented multiple skin lesions that clinically appeared to be pyoderma gangrenosum (PG). However, histological and immunohistochemical examination revealed MF. This case illustrates that PG-like ulcers maybe atypical cutaneous manifestations of MF and exceptionally the presenting sign of this disease.

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“…Mycosis fungoides (MF) has many clinical presentations 1 . MF has been reported to mimic pityriasis alba (hypopigmented MF), acanthosis nigricans, erythema annulare centrifugum, porokeratosis of Mibelli, pigmented purpuric dermatosis, and pyoderma gangrenosum 1–10 . Zackheim and McCalmont 4 proposed that MF deserves the appellation previously afforded to syphilis, that of “the great imitator.” We present two patients with MF that simulated reticular erythematous mucinosis (REM), a condition characterized by reticulated erythema of the upper chest and back with evidence of dermal mucinosis 11,12 …”

Section: Introductionmentioning

confidence: 99%