Mycosis fungoides bullosa: a case report and review of the literature

Abstract

IntroductionMycosis fungoides, the most common type of cutaneous T-cell lymphoma, can manifest in a variety of clinical and histological forms. Bulla formation is an uncommon finding in mycosis fungoides and only approximately 20 cases have been reported in the literature.Case presentationWe present a case of rapidly progressive mycosis fungoides in a 68-year-old Caucasian man who initially presented with erythematous plaques characterised by blister formation.ConclusionAlthough mycosis fungoides bullosa is extremely rare, it has to be regarded as an important clinical subtype of cutaneous T-cell lymphoma. Mycosis fungoides bullosa represents a particularly aggressive form of mycosis fungoides and is associated with a poor prognosis. The rapid disease progression in our patient confirms bulla formation as an adverse prognostic sign in cutaneous T-cell lymphoma.

Reflectance Confocal Microscopy as New Diagnostic Tool in Folliculotropic Mycosis Fungoides

“…In such cases, associated dermatopathological findings may also closely imitate its benign counterpart, i.e., psoriasiform epidermal hyperplasia in psoriasis vulgaris-like variants of mycosis fungoides, subepidermal blisters in bullous pemphigoid-like presentations, interstitial histiocytes and giant cells in granuloma annulare-like mycosis fungoides, or interface dermatitis in mycosis fungoides with lichen planus-like skin lesions [8,9]. In our case, the histopathology of the first biopsy corresponds to an unusual lichen planopilaris.…”

Kutane Lymphome – ein vielgestaltiges Krankheitsbild

“…Farbveränderung Vitiligo [8 -10, 25, 44] Pityriasis alba [11] Pityriasis versicolor [12] postinflammatorische Hyperpigmentierungen [12] Acanthosis nigricans [13] ashy dermatosis [12] Plaque Verruca vulgaris [14] seborrhoische Keratose [15] Morbus Bowen [16] chronisch-diskoider Lupus erythematodes (CDLE) [17] inflammatorischer linearer verruköser epidermaler Nävus (ILVEN) [45] Hyperkeratose/ ekzemartig hyperkeratotisches Handekzem [18] Tinea manuum, Tinea pedis, Tinea corporis [18, 20 -22] Ichthyosis [19] Psoriasis vulgaris [2,23] periorale Dermatitis [24] seborrhoisches Ekzem [25] atopisches Ekzem [12] Keratosis lichenoides chronica [26] Papuloerythroderma Ofuji [27] dyshidrosiformes Handekzem [18] entzündlich Pyoderma gangraenosum [39,40] Erysipel [42,43] figuriert figurierte Erytheme [28,29] Erythema anulare centrifugum [2,30,31] Erythema multiforme [12] granulomatös granulomatöse Rosazea [46] Granuloma anulare [34] Sarkoidose [32] Lepra [12,33] bullös/pustulös bullöse Autoimmundermatosen [35,36] Pustulosis palmoplantaris [18,37,38] sonstig...…”

“…Gelegentlich weisen kutane Lymphome einen granulomatösen Charakter auf und ähneln einer Sarkoidose [32], einer Lepra [12,33] oder einem Granuloma anulare [34]. Auch bullöse Manifestationsformen stellen eine Herausforderung an die klinische Diagnosefindung dar [35,36]. Selbst die phänotypische Imitation einer palmoplantaren Pustulose [18,37,38], eines Pyoderma gangraenosum [39,40], einer Alopecia areata [41] oder eines Gesichtserysipels [42,43] wurden berichtet.…”

T-Cell Non-Hodgkin’s Lymphomas

“…These different presentations may be associated with patterns of biology of disease. For example, bullous MF (mycosis fungoides bullosa) represents a particularly aggressive form of MF and is associated with poor prognosis (Kneitz et al 2010). Conversely, solitary MF (Ally et al 2012) and annular hypopigmented MF (Uhlenhake and Mehregan 2012) appear to have a good prognosis.…”