Mycosis fungoides presenting as reticular erythematous mucinosis

Twersky, Joy M.; Mutasim, Diya F.

doi:10.1111/j.1365-4632.2004.02434.x

Cited by 8 publications

(2 citation statements)

References 19 publications

(16 reference statements)

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“…In 2006, two cases of mycosis fungoides were reported to clinically mimic REM. These variants of mycosis fungoides proved to be more aggressive than typical patch‐stage disease and were very resistant to both topical and systemic therapy 28 . Mycosis fungoides has been reported to mimic many cutaneous diseases, but this was the first report of symptoms mimicking REM.…”

Section: Clinical Featuresmentioning

confidence: 96%

Reticular erythematous mucinosis – a review

et al. 2012

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Reticular erythematous mucinosis (REM) is a rare cutaneous condition often referred to as plaque-like mucinosis and midline mucinosis. Although the exact etiology remains undefined, efforts to elucidate pathogenesis, disease associations, and prospective treatment modalities have been encouraging. Induction of the disease has been associated with viral processes, solar irradiation, specific cell lines, and cytokines such as Interleukin (IL)-1β. Clinically, patients typically develop erythematous macules and papules that coalesce into reticulated patterns on the midline of the chest or back. The lesions have a tendency to respond to systemic antimalarial therapy, but novel therapeutic approaches with ultraviolet A1 light (UVA1) and pulse dye laser (PDL) have been promising. Histologically, REM is associated with a mild, predominantly lymphocytic infiltrate with variable deep perivascular extension. Mucin may be seen in the upper and mid dermis and is prominent around the infiltrate and appendages. IgM deposits may be visualized under direct immunoflourescence along the basal layer. Because of the similarities between REM and tumid lupus, the two disease processes have often been grouped together. The remarkable overlap between the two diseases suggests that the two conditions may actually be the same disease.

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