Hoarseness as a presentation of mycosis fungoides infiltrating the larynx

Abstract

Laryngeal involvement is a rare manifestation of mycosis fungoides (MF), with only nine reported cases of cutaneous T cell lymphoma with laryngeal or vocal cord involvement. Herein, we report the case of a patient with a 7-year history of MF who presented to the emergency department with hoarseness, throat tightness and cough, as well as erythroderma and skin tumours. Laryngoscopy and CT imaging were concerning for lymphomatous involvement of the left false vocal cord. A biopsy was taken of the false vocal cord lesion, which revealed an aberrant immunophenotype consistent with MF. The patient was started on doxorubicin with initial rapid improvement in symptoms. Within 2 months, her respiratory status and skin involvement worsened. Subsequent studies showed bone marrow involvement. The patient expired 4 months after original presentation. This report describes the patient's presentation and clinical course, and reviews the literature on vocal cord and laryngeal involvement of MF.

Transformed mycosis fungoides in an atypical location

“…The clinical presentation of MF at the CAE level is not specific. It may be manifested by otalgia, hypoacusis, or otorrhea [3]. The involvement of the EAC by MF portends a poor prognosis [2].…”

Patient with orbital involvment by mycosis fungoides and COVID-19

“…The most common systemic locations are: lymph nodes, liver, spleen and lungs [4]. Cases of mycosis fungoides involving the central nervous system [5], larynx [6] and eye tissues [7] have also been reported. Lymphopenia, commonly observed in patients with primary cutaneous lymphomas, is associated with a worse prognosis in viral infections, including SARS-CoV-2 [8].…”

A Comprehensive Update of the Atypical, Rare and Mimicking Presentations of Mycosis Fungoides

“…Tumoral MF with large atypical Lc [111] Herpes zoster scar Classic MF [107,112] Palpebral Classic MF [113] MF restricted to traumatized skin…”