A Rare Case of Mycosis Fungoides in the Oral Cavity and Small Intestine Complicated by Perforation

Emge, Drew A.; Bassuner, Juri; Lewis, Daniel; Duvic, Madeleine

doi:10.1159/000452326

Cited by 7 publications

(4 citation statements)

References 51 publications

(62 reference statements)

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“…The most common type reported was MF (CD4 + CD8 − ), followed by double-positive CD4 + CD8 + MF. Only 6 cases of oral MF reported large cell transformation [54][55][56]64]. Case 2 in this report will be the seventh case.…”

Section: Discussion/conclusionmentioning

confidence: 83%

“…There are a total of 43 cases that explicitly mention prior therapies received before the development of oral lesions. Of these, 13 cases (30%) received TSEBT (TSEBT group) [ 27 , 28 , 31 , 35 , 36 , 38 , 44 – 46 , 54 , 55 , 57 ] and 30 cases (70%) did not receive TSEBT (non-TSEBT group) [ 13 , 15 , 16 , 19 , 21 , 22 , 26 , 29 , 33 , 34 , 36 , 37 , 39 , 42 , 43 , 45 , 47 – 50 , 52 , 53 , 56 , 58 , 60 – 63 ] prior to developing oral lesions. The time for oral CTCL to develop after the initial presentation of CTCL was 5.4 years and 7.3 years for the TSEBT and the non-TSEBT groups, respectively.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Oral Mycosis Fungoides: Report of 2 Cases and Review of the Literature

Alexander-Savino¹,

Boye-Doe²,

Bowers³

et al. 2023

Case Rep Dermatol

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Oral and laryngeal cutaneous T-cell lymphoma (CTCL) is rare and usually associated with poor prognosis. Here, we discuss 2 cases of oral CTCL that developed in heavily pretreated patients and provide a review of the literature. The first case is of a 46-year-old African American male with rapidly progressive disease, presenting with a lesion on his hard palate 6 months after being diagnosed with a CD4+CD8+ CTCL. His cutaneous disease was widespread with tumors on >80% of his body surface area. Unfortunately, the patient died 2 ½ years after his CTCL diagnosis and 7 months after developing the oral CTCL lesion. The second case is of a 38-year-old African American male with stage IIb CD3+CD4+CD30+ mycosis fungoides (MF), who developed a tumor on the hard palate 6 months after diagnosis. He received palliative radiation to the oral lesion and multiple lines of systemic therapy for pulmonary, laryngeal, esophageal, and gastric involvement. Biopsy of the gastric lesions showed a CD30+ T-cell lymphoma with the same clonal peak as in his skin but with large cell transformation. Brentuximab vendoin was started, and the patient is now in complete remission, 30 months later. From the 76 cases of oral CTCL that have been reported in the English language, six were of transformed MF. The most common sites affected were the tongue and palate, and the most common presentation were erythematous or ulcerated tumors, plaques, or nodules associated with dysphagia and pain. Oral CTCL typically occurs years after the initial diagnosis of CTCL and portend a poor prognosis with an average survival of just over 1 year after development of oral lesions.

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Section: Discussion/conclusionmentioning

confidence: 83%

Section: Discussion/conclusionmentioning

confidence: 99%

Oral Mycosis Fungoides: Report of 2 Cases and Review of the Literature

Alexander-Savino¹,

Boye-Doe²,

Bowers³

et al. 2023

Case Rep Dermatol

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“…3 There are various case reports of extracutaneous MF involvement in any organ or tissue, the majority of which are anecdotal. [4][5][6] Extracutaneous MF sites can include a wide range of locations, particularly lymph nodes. 2 Oral and GI lesions are uncommon sites of disease involvement, both of which are associated with a poor prognosis and are found in latestage disease.…”

mentioning

confidence: 99%

The oral cavity and gastric involvement in mycosis fungoides while on systemic bexarotene therapy: A rare case report

Bayramgürler

Kazan

Eruyar

et al. 2022

Dermatologic Therapy

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“…Although more than 20 cases of MF with gastric involvement have been reported, detailed clinical courses are available for only six cases, including ours, since 1970. [1][2][3] In a recent report, the median overall survival of patients with visceral involvement was 33 months. 4 On the other hand, in patients with gastric involvement, the median survival time from the onset of gastric symptoms was 3 months.…”

mentioning

confidence: 99%