Kidney tubular injury of rats caused by unripe green betel nuts (Areca catechu)

Rahman, Ave Olivia; Purwakanthi, Anati

doi:10.20885/jkki.vol11.iss1.art5

Cited by 4 publications

(3 citation statements)

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“…14 But then, high dose of betel nut, about higher than 250 mg/kg BW, also cause damage in other organ. [15][16][17][18] Data on antifertility of betel nut in lower doses were limited. Physiology and anatomical of the rat reproductive system are similar to that of humans.…”

Section: Introductionmentioning

confidence: 99%

Antifertility effect of betel nut (Areca catechu L) in male rat

Rahman

Purwakanthi²,

Dewi³

2020

medisians

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Background: Betel nut (Areca catechu L) are traditional beverages in Jambi. Betel nut high dose has a cytotoxic effect on testis and other organs—limited data about the effect of betel nut as male antifertility.Purposes: This study aimed to determine the effect of infertility on betel nut use at a dose of 50 mg/kg body weight (BW) in male rats. Methods: Ten male Sprague Dawney rats that had passed the fertility test, aged 2-3 months and weighing 150-200 grams ware used in this study. The rat was grouped into two groups randomly. Group 1, as the negative control, were received aqua dest, and group 2 was treated by betel nut with dose 50 mg/kg BW for 35 days. When terminated, testis weight weighed using micro scales. Blood collected for measuring testosterone levels. Histopathology assessment of testis used Hematoxylin Eosin Staining and sperm counting from cauda epididymis.Results: The weight of testis in the group received betel nut was lower than the control group. The histopathology of testis showed shrunk, reduced the diameter of seminiferous tubules, and like cytolytic lesions in the germinal layer—the total sperm number and progressive sperms also lower than the control group (p<0.05). There was no abnormality in Leydig cell and interstitium tissue. Male rats after treatment could not impregnate the female rats.Conclusion: Betel nut at dose 50 mg/kg BW have antifertility activity in male rats.

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Section: Introductionmentioning

confidence: 99%

Antifertility effect of betel nut (Areca catechu L) in male rat

Rahman

Purwakanthi²,

Dewi³

2020

medisians

Self Cite

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“…Moreover, increased cell membrane permeability led to cytoplasmic vacuolation [ 41 ]; pyknotic nuclei indicated apoptotic changes [ 42 ]. In addition, cast formation indicated tubular injury, as clarified by Rahman and Purwakanthi [ 43 ]. Partial tubular obstruction or alterations in the structure of the tubular basement membrane were responsible for tubular dilatation [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Treadmill Exercise Training Ameliorates Functional and Structural Age-Associated Kidney Changes in Male Albino Rats

Salem

Faried

2021

The Scientific World Journal

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Aging is a biological process that impacts multiple organs. Unfortunately, kidney aging affects the quality of life with high mortality rate. So, searching for innovative nonpharmacological modality improving age-associated kidney deterioration is important. This study aimed to throw more light on the beneficial effect of treadmill exercise on the aged kidney. Thirty male albino rats were divided into three groups: young (3-4 months old), sedentary aged (23-24 months old), and exercised aged (23-24 months old, practiced moderate-intensity treadmill exercise 5 days/week for 8 weeks). The results showed marked structural alterations in the aged kidney with concomitant impairment of kidney functions and increase in arterial blood pressure with no significant difference in kidney weight. Also, it revealed that treadmill exercise alleviated theses effects in exercised aged group with reduction of urea and cystatin C. Exercise training significantly decreased glomerulosclerosis index, tubular injury score, and % area of collagen deposition. Treadmill exercise exerted its beneficial role via a significant reduction of C-reactive protein and malondialdehyde and increase in total antioxidant capacity. In addition, exercise training significantly decreased desmin immunoreaction and increased aquaporin-3, vascular endothelial growth factor, and beclin-1 in the aged kidney. This study clarified that treadmill exercise exerted its effects via antioxidant and anti-inflammatory mechanisms, podocyte protection, improving aquaporin-3 and vascular endothelial growth factor expression, and inducing autophagy in the aged kidney. This work provided a new insight into the promising role of aerobic exercise to ameliorate age-associated kidney damage.

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“…Kidneys and the liver are organs often used as parameters for assessing toxicity. Several studies show that extract of areca nuts or arecoline also cause damages to other organs, such as the liver and kidneys, especially in long-term administration and high doses (9,(16)(17)(18)(19)(20). Determination of an effective and safe dose range is needed to develop areca nuts as a candidate for an oral herbal male contraceptive.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antifertility Effect and Toxicity of Areca nut as Oral Contraceptive: Study on Male Rats

Rahman

Dewi

Geniro

et al. 2022

JKB

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Currently, very few male contraceptive methods are available. Areca nuts are known to have an antifertility effect, but the effective, safe dose is not certainly known. Data on its effectiveness and safety are needed to develop the potential of the areca nuts as an herbal contraceptive in men. This study determines the antifertility effect of areca nut administration at doses of 40, 30, and 20 mg/kgBW and their safety on the kidneys and liver. The green-colored raw areca nuts were used. The treatment groups were male rats whose fertility status was known before treatment. The control group were given distilled water. The treatment were given one dose a daily dissolved for 28 days of treatment, then male rats were bred again. Rats were terminated for histopathological examination of liver, kidneys, testes, and for analysis of spermatozoa. The administration of areca nuts caused a decreasing number of litters, but only the group given 40 mg/kgBW dose had a significant decrease (p<0.05). There were a damaged testes, a decreasing number and motility of spermatozoa as well as increasing spermatozoa abnormalities. There were no changes in liver tissue, but there was a mild grade cast in kidney tissue. Areca nut have antifertility effect in male rats with dose dependent manner, histopathological examination revealed cast nephotoxic but not hepatotoxic.

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Kidney tubular injury of rats caused by unripe green betel nuts (Areca catechu)

Cited by 4 publications

References 0 publications

Antifertility effect of betel nut (Areca catechu L) in male rat

Antifertility effect of betel nut (Areca catechu L) in male rat

Treadmill Exercise Training Ameliorates Functional and Structural Age-Associated Kidney Changes in Male Albino Rats

Evaluation of the Antifertility Effect and Toxicity of Areca nut as Oral Contraceptive: Study on Male Rats

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