Investigation of the effects of the chronic administration of some antihypertensive drugs on enzymatic and non-enzymatic oxidant/antioxidant parameters in rat ovarian tissue

Abstract

We divided the drugs into four groups according to their biochemical side effect potentials in ovarian tissue: (I) Drugs which have no clear negative effect on ovarian tissue: clonidine, rilmenidine; (II) Drugs which have mild negative effect on ovarian tissue: methyldopa; (III) Drugs which have moderate negative effect on ovarian tissue: amlodipine; (IV) Drugs which have severe negative effect on ovarian tissue: ramipril. These data might be useful in the selection of the least toxic antihypertensive drug in pregnant and/or normal females.

Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats

“…The dihydropyridine compounds have a reducing nature or hydrogen donor properties making them having the ability to donate protons and electrons to the lipid peroxide molecules to reduce it into a non-reactive form thereby blocking the peroxidation process (Vitolina et al, 2012). Regarding the anti-inflammatory effect of amlodipine, Salman et al (2011) reported similar decreases in MPO activity during studying the effects of chronic administration of some antihypertensive drugs on enzymatic and non-enzymatic oxidant/antioxidant parameters in rat ovarian tissue. Side by side, Yasu et al (2013) concluded that amlodipine could inhibit leucocyte adhesion and MPO release.…”

Tissue Damage and Oxidant/Antioxidant Balance

“…Isaoglu et al [27] reported a significant increase in the levels of oxidants-compared with the levels in the healthy group-in ovary tissue in which only ischemia occurred. Increases in the levels of oxidant indicators and decreases in the levels of antioxidant indicators have also been observed in ovaries damaged by drugs [28].…”

Effect of low and high dose of favipiravir on ovarian and reproductive function in female rats: Biochemical and histopathological evaluation

“…This condition is known as oxidative stress in the literature (Kisaoglu et al 2013). In a previous study, whether damage occurred in the ovaries was evaluated by oxidant and antioxidant levels (Salman et al 2011). Recent studies have shown that histopathological damage in the ovarian tissue is associated with oxidant-antioxidant levels (Ince et al 2021).…”