Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats

Mohammed, Nesreen E.M.; Messiha, Basim Anwar Shehata; Abo-Saif, Ali A.

doi:10.1016/j.jsps.2015.04.004

Cited by 22 publications

(16 citation statements)

References 66 publications

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“…Our results also showed elevated serum ALT, AST, ALP, GGT, LDH and T.Bil (Figure ) in DENA‐treated rats, indicating massive hepatocyte turnover . Serum transaminases in particular are among the most sensitive indicators of hepatocyte injury in different experimental models …”

Section: Discussionsupporting

confidence: 63%

Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence

Hassan

Mansour

Abo-Youssef

et al. 2017

Clin Exp Pharma Physio

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Currently, the outcomes of conventional chemotherapeutic approaches are unsatisfactory. Clinical application of nanoparticles seems promising. We aim to evaluate the possible antitumor activity of zinc oxide nanoparticles (ZnONPs) as a chemotherapeutic approach in in vitro and in vivo experimental models. An in vitro study was performed on three different cell lines, namely human hepatocellular carcinoma (HEPG2), human prostate cancer (PC3), and none-small cell lung cancer (A549) cell lines. An in vivo study using diethylnitrosamine (DENA)-induced HCC in adult male Wistar rats was conducted to investigate the potential antitumor activity of ZnONPs in HCC and the possible underlying mechanisms. Hepatocellular carcinoma (HCC) was induced by oral administration of DENA given in drinking water (100 mg/L) for 8 weeks. Rats were allocated into four groups, namely a control group, an HCC control group receiving DENA alone, a ZnONPs (10 μg/kg per week, intravenous (i.v.) for 1 month) control group, and a ZnONPs treatment group (receiving ZnONPs + DENA). ZnONPs significantly reduced the elevated serum levels of HCC-related tumor markers alphafetoprotein and alpha-l-fucosidase and the apoptotic marker caspase-3 compared with the untreated HCC rats. In addition, treatment with ZnONPs significantly decreased the elevated levels of hepatocyte integrity and oxidative stress markers as compared with the untreated HCC control group. Furthermore, the histopathological study revealed anaplasia and fibrous degenerations which were significantly corrected by ZnONPs treatment. In conclusion, administration of ZnONPs exhibited a promising preclinical anticancer efficacy in HCC and could be considered as a novel strategy for the treatment HCC in clinical practices.

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Section: Discussionsupporting

confidence: 63%

Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence

Hassan

Mansour

Abo-Youssef

et al. 2017

Clin Exp Pharma Physio

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“…The genetic factors play pivotal role in the occurrence and progression of primary hypertension (Chen et al, 2013, Dierks et al, 2013, Liu et al, 2011b, Takeuchi et al, 2010, Zhang and Liuxing, 2008, Lackland and Weber, 2015). In recent years, with the development of molecular genetics and related technologies, gene research on the patients with primary hypertension is carried out gradually and achieved gratifying results (Mohammed et al, 2016, Peng et al, 2017, Ge et al, 2016). The most commonly used method of studying hypertension related genes include candidate gene study and genome-wide association study.…”

Section: Discussionmentioning

confidence: 99%

Expression level of fibroblast growth factor 5 (FGF5) in the peripheral blood of primary hypertension and its clinical significance

Ren

Jiao

Zhang

2018

Saudi Journal of Biological Sciences

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“…A recent study of Mohammed et al was about the protective effect of AML, lisinopril, and allopurinol on P-induced hepatotoxicity. 36 In this study, single dose of these three drugs was administrated for 14 days and then P toxicity was induced. At the end some, oxidative stress parameters (TBAR, GSH, CAT, NOx, and MPO) and liver enzymes (ALT and AST) were measured and tissues were evaluated by H&E staining.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of an L-type calcium channel blocker, amlodipine, on paracetamol-induced hepatotoxicity in rats

et al. 2018

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Paracetamol (P), one of the most popular and commonly used analgesic and antipyretic agents, causes hepatotoxicity in overdoses. Amlodipine (AML), an L-type calcium channel blocker, has been shown to have anti-inflammatory activity by reversing the effect of calcium in the inflammation pathogenesis. In this study, the hepatoprotective activity of AML on P-induced hepatotoxicity was evaluated. Thirty male albino Wistar rats were divided into five groups: (1) control, (2) 2 g/kg of P, (3) 2 g/kg of P + 5 mg/kg of AML, (4) 2 g/kg of P + 10 mg/kg of AML, and (5) 10 mg/kg of AML. Some liver enzymes, oxidative parameters, cytokine mRNA expressions, histopathology, and immunohistochemical studies were performed in liver and blood samples. The serum levels of alanine aminotransferase and aspartate aminotransferase and the mRNA expression of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta in the liver tissues were significantly increased in the group treated with P. The superoxide dismutase and glutathione parameters decreased and malondialdehyde levels increased in the livers of the rats treated with P. All these parameters were increased with both doses of the AML similar to the control group. A histopathological examination of the liver showed that AML administration ameliorated the P-induced inflammatory liver damage. In immunohistochemical staining, the expression of TNF-α in the cytoplasm of the hepatocytes was increased in the P group but not in other treatment groups when compared to the control. In conclusion, AML treatment showed significant protective effects against P-induced hepatotoxicity by increasing the activity of antioxidants and reducing inflammatory cytokines.

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Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats

Abstract: Amlodipine, lisinopril or allopurinol can protect against acetaminophen-induced hepatotoxicity, showing mechanistic roles of calcium channels, angiotensin converting enzyme and xanthine oxidase enzyme in the pathogenesis of hepatotoxicity induced by acetaminophen.

Cited by 22 publications

References 66 publications

Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence

Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence

Expression level of fibroblast growth factor 5 (FGF5) in the peripheral blood of primary hypertension and its clinical significance

Protective effect of an L-type calcium channel blocker, amlodipine, on paracetamol-induced hepatotoxicity in rats

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