Introducing new method for the synthesis of polycyclic compounds containing [1,3]dithiine derivatives, with anticancer and antibacterial activities against common bacterial strains between aquatic and human

Moghaddam‐Manesh, Mohammadreza; Hosseinzadegan, Sara

doi:10.1002/jhet.4345

Cited by 14 publications

(8 citation statements)

References 23 publications

(48 reference statements)

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“…the cells were treated with concentrations of 6.25 μM/ml, 12.5 μM/ml, 25 μM/ml, 75 μM/ml, 150 μM/ml, and 300 μM/ml of Y-MOF and pyrazolopyranopyrimidines derivatives for 48 h. After 48 h, the media from the well were removed and added 150 μL of fresh media plus 50 μL of MTT solutions (prepared as 2 mg/ml in PBS) and for 4 h were incubated. Finally, MTT solutions were removed and DMSO (200 μL) were added to each well and by spectrophotometer (BioTek Instruments, Inc., Bad Friedrichshall, Germany) the absorbance at 570 nm was read ( Heidari Majd et al, 2017 ; Moghaddam‐manesh et al, 2021 ; Moghaddam‐Manesh and Hosseinzadegan, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

Saleh

Achmad²,

Daminov³

et al. 2022

Front. Chem.

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Novel Yttrium-metal–organic framework (Y-MOF) was synthesized under optimal conditions of microwave with a power of 20 W, the temperature of 30 degrees of centigrade, and time duration of 10 min. The products were characterized by SEM (morphology and size distribution), TGA (thermal stability), BET technique (surface area), and FTIR (characterization of the related group). The Yttrium-metal–organic framework (Y-MOF) synthesized in this study, after identifying and confirming the structure, was used as an efficient and recyclable catalyst in the synthesis of new pyrazolopyranopyrimidine derivatives. Following the study of the properties and applications of Y-MOF, its anticancer properties on breast cancer cells based on the MTT method were evaluated, and significant results were observed. In addition, the anticancer properties of the pyrazolopyranopyrimidine derivatives were investigated.

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Section: Methodsmentioning

confidence: 99%

RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

Saleh

Achmad²,

Daminov³

et al. 2022

Front. Chem.

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“…Antimicrobial activity, including antibacterial and antifungal, against Gram-positive, Gram-negative, and specialized aquatic bacterial species was performed based on CLSI (Clinical and Laboratory Standards Institute) methods (Etemadi et al, 2016;Moghaddam-Manesh et al, 2020;Moghaddam-Manesh and Hosseinzadegan, 2021).…”

Section: Antibacterial and Antifungal Methodsmentioning

confidence: 99%

“…The microplate containing the mixtures were placed in an incubator set at right temperature (for bacterial species: 37 °C; for fungal species 27 °C) for 48 h. Clear wells indicate the lack of bacterial growth, and turbid wells indicate bacterial growth at that concentration. The first well from which transparency started was reported as the minimum inhibitory concentration (Etemadi et al, 2016;Moghaddam-Manesh et al, 2020;Moghaddam-Manesh and Hosseinzadegan, 2021).…”

Section: Mic Valuementioning

confidence: 99%

MgO NPs catalyzed the synthesis of novel pyridin-3-yl-pyrimidin-2-yl-aminophenyl-amide derivatives and evaluation of pharmacokinetic profiles and biological activity

Gani

Al-Obaidi

2023

Front. Mater.

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In this study, novel pyridin-3-yl-pyrimidin-2-yl-aminophenyl-amide derivatives using two methods, namely, using trimethylamine as a classical method and using magnesium oxide nanoparticles, were synthesized. Biological activities of the derivatives such as inhibitors of receptor tyrosine kinase, pharmacokinetics profiles, anticancer activity against lung cancer, antibacterial and antifungal activity against specialized aquatic bacterial species, Gram-positive and Gram-negative species, and fungal species, and antioxidant activity were evaluated. The structures of synthetic derivatives were confirmed using FT-IR, 1H-NMR, and 13C-NMR spectra and elemental analysis. The results showed that these compounds possess more cytotoxic activity than the reference drug (i.e., imatinib). Furthermore, compound IIB gives ten-fold lower IC50 values (0.229 μM) than imatinib (2.479 μM) when tested against (A549) lung cancer cell lines employing MTT assay. To investigate antibacterial and antifungal activities, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) parameters were evaluated, and derivative IIC showed the highest activity (MIC 16–128 μg/mL), which can be attributed to its structure. In addition, the antibacterial and antifungal properties of the derivatives were higher than some drugs. The antioxidant property of the derivatives was studied by using the DPPH (2,2-diphenylpicrylhydrazyl) method, and the results showed that the evaluated IC50 value was close to the IC50 value of ascorbic acid (4.45–4.83 μg/mL).

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“…Anticancer activity studies of CCPSF NPs using the MTT method and previously reported on MCF-7 breast cancer cells were done. The densities of 1.2 × 10 4 (cells/well) MCF-7 breast cancer cells for 24 and 48 h in concentrations of 5, 10, 20, 40, 80, 120, and 200 mg/ml CCPSF NPs were tested ( Moghaddam-Manesh and Hosseinzadegan, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

A green chemistry approach for oxidation of alcohols using novel bioactive cobalt composite immobilized on polysulfone fibrous network nanoparticles as a catalyst

et al. 2022

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In this study, cobalt composite immobilized on polysulfone fibrous network nanoparticles (CCPSF NPs) were synthesized in a controllable and one-step way under microwave-assisted conditions. The structure of CCPSF NPs was characterized by SEM images (for morphology and size distribution), TGA (for thermal stability), BET technique (for the specific surface area), FT-IR spectroscopy (for relation group characterization), and XRD patterns (for crystal size). The oxidation of the primary and secondary alcohols to aldehyde and ketone was investigated using synthesized CCPSF NPs under solvent-free microwave-assisted conditions, and high oxidizing activity was observed. In addition to oxidation properties, the anticancer activity of the synthesized CCPSF NPs in breast cancer was evaluated by the MTT method , and significant results were obtained.

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Introducing new method for the synthesis of polycyclic compounds containing [1,3]dithiine derivatives, with anticancer and antibacterial activities against common bacterial strains between aquatic and human

Cited by 14 publications

References 23 publications

RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

MgO NPs catalyzed the synthesis of novel pyridin-3-yl-pyrimidin-2-yl-aminophenyl-amide derivatives and evaluation of pharmacokinetic profiles and biological activity

A green chemistry approach for oxidation of alcohols using novel bioactive cobalt composite immobilized on polysulfone fibrous network nanoparticles as a catalyst

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