Novel Yttrium-metal–organic framework (Y-MOF) was synthesized under optimal conditions of microwave with a power of 20 W, the temperature of 30 degrees of centigrade, and time duration of 10 min. The products were characterized by SEM (morphology and size distribution), TGA (thermal stability), BET technique (surface area), and FTIR (characterization of the related group). The Yttrium-metal–organic framework (Y-MOF) synthesized in this study, after identifying and confirming the structure, was used as an efficient and recyclable catalyst in the synthesis of new pyrazolopyranopyrimidine derivatives. Following the study of the properties and applications of Y-MOF, its anticancer properties on breast cancer cells based on the MTT method were evaluated, and significant results were observed. In addition, the anticancer properties of the pyrazolopyranopyrimidine derivatives were investigated.

The emergence of COVID-19 almost coincided with the beginning of an active phase of the digitalization process in all areas, including the healthcare system. Moreover, COVID-19 unwittingly became the impetus that accelerated the adoption of digital technologies, and initiated new, often innovative solutions to combat both the virus and its devastating social and economic consequences. The purpose of the study: the current study conducts a literature review of existing scientific reports in the field of digital contact-tracing COVID-19 using artificial intelligence (AI) technologies, to discuss issues related to the security of personal data when using official mobile applications, to draw conclusions and make recommendations in the field of effective and ethical management of digital contact-tracing as one of the main tools for preventing the spread of the pandemic. Scientific reports contained in the scientific research databases of Ebsco Publishing and SpringerLink for the period March 2020 — April 2021 were analyzed. Digital contact-tracing solutions have found their important place among other anti-epidemic measures in many countries around the world. However, the same solutions, but already using AI, are still gaining popularity. National governments in numerous developed and developing countries understand the importance of national contact-tracing systems, which in turn has introduced such approaches in national pandemic response strategies. Conclusion: Digital contact-tracing technologies using AI can be an effective tool in the fight against COVID-19 and similar pandemics. However, such digital systems are still at a preliminary stage of their development and implementation, and it will take time before the results will be visible. Very few of the considered examples and models of digital tracing solutions using AI technologies have operational maturity at this stage.

Background and Aims In a normal physiological state, there are many regulatory molecules that act as inhibitors of mineral formation to prevent the spread of tissue hardening. In patients with CKD, the levels or functions of these inhibitors may be abnormal, which in turn may predispose to or enhance ectopic calcification. to increase the effectiveness of early diagnosis of demineralization of the bone skeleton in patients with stage V chronic kidney disease receiving hemodialysis. Method The study included 94 CKD patients receiving hemodialysis for 15 months. The average age of the patients was 42.13±12.16 years. Etiologically, the cohort of patients included in the study was diverse, with a significant predominance of chronic glomerulonephritis as the cause of CKD in 72 patients, chronic pyelonephritis in 22 patients occupied the second place among the causes of CKD, the remaining causes occurred with a single frequency. Anemia was diagnosed in 71 patients. The observation lasted 12 months. Pathological changes in phosphorus-calcium metabolism and secondary hyperparathyroidism in patients were associated with a significant decrease in bone mineral density, it was shown both for the bodies of the lumbar vertebrae and for the femoral neck, the significance of the difference from the control group for absolute values of mineral density and relative deviation. Results In dynamics for 6 months in the general cohort of patients, there was a significant increase in the absolute mineral density of the femoral neck by 11.38%, p<0.01 the reliability of the difference with the baseline data, and a decrease in the degree of deviation of the mineral density index from the age norm -3.13%, p<0.05 for the bodies of the lumbar vertebrae and -4.01%, p<0.01 for the femoral neck, which confirms the effectiveness of osteoporosis therapy. In the present study, in 45 patients 37.5% at the time of inclusion in the study in the bodies of the lumbar vertebrae, the T-index was higher than -2.5 SD, in respect of the femoral neck – in all patients, the T was lower than 2.5 ST. The study of bone mineral density in patients with HCBP, the decrease of which reflects the syndrome of renal osteodystrophy, developing in response to secondary hyperparathyroidism, against the background of osteoporosis therapy. Conclusion In patients with CKD, against the background of programmed hemodialysis, there is a decrease in bone mineral density (1.93 times the bodies of the lumbar vertebrae and 2.83 times the femoral neck). The use of calcium carbonate, biphosphonate and vitamin D3 contributes to an increase in the mineral density of the femoral neck by 8.64% (p<0.05). The introduction of sevelamer hydrochloride into the therapy regimen increases the effectiveness of therapy and increases the mineral density of the bodies of the lumbar vertebrae by 5.96% (p< 0.05) and the femoral neck by 14.04% (p<0.05).

Introduction: A wide range of oral hypoglycemic drugs with various mechanisms of effect are available for the treatment of patients with 2nd type diabetes mellitus today. Despite the high effectiveness of these agents in the normalization of glycemia, they cause different chronic complications in many patients with 2nd type diabetes mellitus. However, during the last years, a range of principal new data has been accumulated on the pleiotropic effects of the last classes of oral hypoglycemic agents -inhibitors of the 2nd type sodiumglucose cotransporter (SGLT2). Materials and Method:Three electronic databases were checked to find out studies reporting the data on the mechanisms and clinical significance of the nephroprotective effect of inhibitors of the sodium-glucose cotransporter of 2nd type (glyphlozines) in patients with 2 nd type diabetes mellitus. The primary outcome was to learn the worldwide tendency on this matter and to compare the results of different researchers. Results:We found 25 studies as eligible for our review. The review presents data on the mechanisms and clinical significance of the nephroprotective effect of inhibitors of the sodium-glucose cotransporter of 2nd type (glyphlozines). The effects associated with the influence of representatives of this pharmacological group on the glomerular filtration rate, glycemia, diuresis, ketogenesis and other factors are discussed. The results of recent experimental and clinical studies aimed at studying certain aspects of the nephroprotective effect of SGLT2 inhibitors in 2nd type diabetes mellitus and other pathological conditions were analyzed. Conclusion.SGLT2 inhibitors associate with a multicomponent nephroprotective effect, which confirmed by the results of both experimental and clinical studies. The nephroprotective potential of SGLT2 inhibitors is maximally realized in the presence of diabetes and remains not entirely clear in the case of another kidney pathology.

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