RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

Abstract

Novel Yttrium-metal–organic framework (Y-MOF) was synthesized under optimal conditions of microwave with a power of 20 W, the temperature of 30 degrees of centigrade, and time duration of 10 min. The products were characterized by SEM (morphology and size distribution), TGA (thermal stability), BET technique (surface area), and FTIR (characterization of the related group). The Yttrium-metal–organic framework (Y-MOF) synthesized in this study, after identifying and confirming the structure, was used as an efficient and recyclable catalyst in the synthesis of new pyrazolopyranopyrimidine derivatives. Following the study of the properties and applications of Y-MOF, its anticancer properties on breast cancer cells based on the MTT method were evaluated, and significant results were observed. In addition, the anticancer properties of the pyrazolopyranopyrimidine derivatives were investigated.

Recent progress of nanocatalyst in the synthesis of heterocyclic compounds by barbituric acids

“…It can be used for up to five runs without substantially decreasing established efficiency. 87 For Y-MOF synthesis, dipicolinic acid and Yttrium (III) nitrate pentahydrate in water were added to the microwave bath at 30 C (10 min) and microwave power of 140 W. Then the silvery crystals of Y-MOF nanostructure are formed after that centrifuge is used to separate Y-MOF nanocatalyst. Finally, the nanocatalyst was rinsed by DMF.…”

“…Finally, the nanocatalyst was rinsed by DMF. 87 Scheme 75 offers the mechanism of synthesizing products 17. The first step was started by the reaction of hydrazine 15 with EAA ( 16), to produce pyrazole 20, which turned into enolate form 20a.…”

“…The first step was started by the reaction of hydrazine 15 with EAA ( 16), to produce pyrazole 20, which turned into enolate form 20a. In the next step, Knoevenagel condensation was performed between BA 87 A new, efficient, and recoverable organocatalyst hexamethylenetetramine-based ionic liquid immobilized on the (Cr)101-MIL metal-organic scaffold was successfully employed for the one-pot, synthesis of pyridodipyrimidines 91 through the reaction of BA 1, aryl aldehydes 2, and 6-amino-1,3-dimethyl uracil/6-aminouracil 90, in a solvent-free environment (Scheme 76). Some benefits of this method include reduced reaction period, smooth conditions, ease of product isolation, efficient S C H E M E 7 7 (Cr)101-MIL@BAIL-HMTA catalyst formation process.…”

“…In addition, the applications and properties of Y‐MOF, and its anticancer activities on breast cancer cells were confirmed based on the MTT procedure. It can be used for up to five runs without substantially decreasing established efficiency 87 …”

“…Afterward, intermediate 11 reacted with substance 20a Michael addition, and intermediate 21 was produced. At the end, intramolecular reaction intermediate 21 generated intermediate 22 , and by losing an H 2 O from intermediate 22 , the expected product 17 was obtained 87 …”