Influence of Synbiotics on Selected Oxidative Stress Parameters

Abstract

The aim of the present study was to assess synbiotic (Lactobacillus casei + inulin) influence on oxidative stress parameters such as concentrations of malondialdehyde (MDA), hydrogen peroxide (H2O2), glutathione, and free sulfhydryl groups content. Experiments were carried out on healthy volunteers (n = 32). The subjects were divided into women group (n = 16) and men group (n = 16) and randomly assigned to synbiotic and control groups. Blood samples were collected before synbiotic supplementation and after 7 wks, at the end of the study. The administration of synbiotic resulted in a significant decrease in MDA (p < 0.01), H2O2 (p < 0.01), and GSSG concentrations (p < 0.05) as compared with the control groups and significant increase in the concentrations of GSHt (p < 0.001), GSH (p < 0.01), and -SH group content (p < 0.05) versus control. Synbiotics containing L. casei plus inulin may have positive influence on selected oxidative stress markers.

Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome

“…Supplementation with probiotics and vitamin C increased the activity of antioxidant enzymes in the serum, brain and kidneys in type 1 diabetic rats [48]. Administration of L. casei with inulin to healthy volunteers resulted in a significant increase in plasma CAT activity [49] and in a significant decrease in plasma MDA and oxidized glutathione concentrations and increased free thiol and glutathione contents [50]. Moreover, probiotics provided significant protection against mercury-induced toxicity by preventing alterations in the levels of GPx and SOD [51].…”

Biological Properties and Phytochemical Analysis of Fractions and Total Extracts of Cylicodiscus gabunensis Harms and Morinda lucida Benth

“…In fact, certain proteins make it possible to detect different types of pathogens, thus triggering inflammation [25]. Several studies have shown the influence of certain microorganisms on the parameters of oxidative stress [26]. The plant extracts of Cylicodiscus gabunensis and Morinda lucida have an anti-free radical potential which would allow them to play a beneficial role in terms of preventive actions for human health.…”

Immunomodulatory Effects of Probiotics on Cytokine Profiles

“…Common prebiotics used in the preparation of synbiotics and their natural sources are summarized in Table 2 . In vivo , Lactobacillus casei has been found to produce significant amounts of GSHt, GSH, and -SH free groups by fermenting inulin, whereas physiological stress results in lower GSH concentrations with large amounts of oxidative stress markers [ 26 ]. Verma and Shukla [ 27 ] revealed that L. rhamnosus and L. acidophilus lead to the formation of large quantities of antioxidants, mainly GSH, with inulin being a nondigestible carbohydrate in the small intestine.…”