Biological Properties and Phytochemical Analysis of Fractions and Total Extracts of Cylicodiscus gabunensis Harms and Morinda lucida Benth

Abstract

Two plants used in traditional medicine from Gabon were studied. The aim of this study was to study the biological properties and phytochemical analysis of Cylicodiscus gabunensis Harms and Morinda lucida Benth. These extracts were subjected to antimicrobial (diffusion, dilution), antioxidant (DPPH, ABTS) and inhibition of protein denaturation. The water-ethanol, water-acetone extracts and the partitioned extracts (F1 and F2) of Cylicodiscus gabunensis showed the greatest antibacterial activity on the majority of microbial strains and a good inhibition of denaturation with IC50 of 58.75 ± 2.10; 19.16 ± 2.00; 69.50 ± 2.00 and 17.49 ± 1.20 μg / mL respectively, compared to standards. Similarly, these extracts of Cylicodiscus gabunensis have anti-free radical capacities close to standards including vitamin C and butylated hydroxyanisole. The phytochemicals present in the extracts of Cylicodiscus gabunensis and Morinda lucida may be responsible for the biological activities studied.

Anti-Onchocercal Properties of Extracts of Scoparia dulcis and Cylicodiscus gabunensis

“…This suggests that the active principles in the extracts may be from the groups of compounds mentioned above. This is in conformity with previous phytochemical studies, which revealed the presence of these secondary metabolites to be responsible for the medicinal properties of these plants [ 16 , 33 ].…”

“…Tis suggests that the active principles in the extracts may be from the groups of compounds mentioned above. Tis is in conformity with previous phytochemical studies, which revealed the presence of these secondary metabolites to be responsible for the medicinal properties of these plants [16,33]. Te isolation of pure compounds from these plant extracts is recommended to determine their full active potential and ascertain the actual phytochemicals responsible for the anti-onchocerca activity of the plant extracts.…”

“…Cylicodiscus gabunensis (Fabaceae) is an indigenous medicinal plant that is widely distributed in West and Central Africa. Extracts from its stem bark have been used for the treatment of viginitis, jaundice, antimalaria, antibacteria, anti-infammatory, antipyretics, and as soaps and mouthwash by some communities [14][15][16][17]. Previous phytochemical analysis has revealed the presence of triterpenoids, saponins, and phenolics with some defnite pharmacological antimalaria, antifree radical, and antibacteria properties [16,18,19].…”

“…Extracts from its stem bark have been used for the treatment of viginitis, jaundice, antimalaria, antibacteria, anti-infammatory, antipyretics, and as soaps and mouthwash by some communities [14][15][16][17]. Previous phytochemical analysis has revealed the presence of triterpenoids, saponins, and phenolics with some defnite pharmacological antimalaria, antifree radical, and antibacteria properties [16,18,19]. Ethnopharmacological information about S. dulcis and C. gabunensis indicated their use by an ethnic group in Cameroon to treat flarial infections like onchocerciasis.…”

Chemical Characterisation and Biological Effects of Essential Oils of Four Gabonese Medicinal Plants

“…This practice, which consists in exploiting the knowledge accumulated over the centuries, uses plants whose flora abounds in an important reserve of aromatic and medicinal character for traditional use. Carapa procera, Chenopodium ambrosioides, Mammea africana and Maranthes gabunensis represent some of the plants frequently used by the populations of Haut-Ogooué for their antibacterial, antihypertensive, analgesic, febrifuge, anti-inflammatory, antimalarial, anthelmintic, insecticide and insect repellent properties [3,4]. For the moment, chemical and biological investigations remain to be carried out in order to develop them and be able to better exploit their properties.…”