Influence of Alpha-Lipoic Acid on Streptozotocin Induced Diabetic Cardiomyopathy in Adult Male Albino Rats

Asker, Samar A.; Mazroa, Shireen A.; Abdel-Malek, Hala

doi:10.1097/00767537-201003000-00010

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…In keeping with the previous studies, we also found that serum MDA levels are increased and lipoic acid treatment causes a significant decrease in serum MDA levels in STZ-induced diabetic rats [44,45].…”

Section: Paraoxonase Activitysupporting

confidence: 92%

Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats

Özgün

Gökmen

et al. 2016

Exp Clin Endocrinol Diabetes

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The aim of the present study was to investigate the effect of streptozotocin-induced diabetes mellitus and lipoic acid treatment on serum paraoxonase-1 and paraoxonase-3 protein levels and paraoxonase, arylesterase and lactonase activities.36 rats were equally and randomly divided into 4 groups as control, lipoic acid, diabetes and diabetes+lipoic acid. To induce diabetes, a single dose of streptozotocin (40 mg/kg) was injected intraperitoneally to diabetes and diabetes+lipoic acid groups. Lipoic acid (10 mg/kg/day) was injected intraperitoneally for 14 days to lipoic acid and diabetes+lipoic acid groups. Serum PON1 and PON3 protein levels were measured by western blotting. Serum paraoxonase, arylesterase and lactonase activities were determined by the measuring initial rate of substrate (paraoxon, phenylacetate and dihydrocoumarin) hydrolysis.Streptozotocin-induced diabetes mellitus caused a significant decrease whereas lipoic acid treatment caused a significant increase in serum PON1 and PON3 protein levels and paraoxonase, arylesterase and lactonase activities. The increase percent of serum PON3 protein was higher than that of serum PON1 protein and the increase percent of serum lactonase activity was higher than that of serum paraoxonase and arylesterase activities in diabetes+lipoic acid group.We can report that, like PON1 protein, PON3 protein and actually its lactonase activity may also have a role as an antioxidant in diabetes mellitus and lipoic acid treatment may be useful for the prevention of the atherosclerotic complications of diabetes by increasing serum PON1 and PON3 protein levels and serum enzyme activities.

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Section: Paraoxonase Activitysupporting

confidence: 92%

Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats

Özgün

Gökmen

et al. 2016

Exp Clin Endocrinol Diabetes

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Section: Introductionmentioning

confidence: 99%

“…Cardiac complications observed in type 1 and type 2 diabetes mellitus (T1DM and T2DM, respectively) patients are a major public health problem in modern societies . In this regard, it was shown that diabetic cardiomyopathy (DC) occurs independent of any other cardiovascular risk factor and is responsible for about 80% of deaths among diabetic patients . It is currently accepted that reactive oxygen species (ROS) due to hyperglycaemia or to the increase in free fatty acids (FFAs) influx from the periphery to the heart are the initial trigger responsible for the cardiac apoptosis and impaired left ventricular (LV) function that is seen in T1DM and T2DM patients …”

Section: Introductionmentioning

confidence: 99%

Chronic consumption of a high‐fat diet rich in corn oil activates intrinsic cell death pathway and induces several ultrastructural changes in the atria of healthy and type 1 diabetic rat

Eid

Eleawa

Alkhateeb

et al. 2019

Clin Exp Pharma Physio

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This study investigates the effect of chronic consumption of a high-fat diet rich in corn oil (CO-HFD) on atrial cells ultrastructure, antioxidant levels and markers of intrinsic cell death of both control and type 1 diabetes mellitus (T1DM)-induced rats.Adult male rats (10 rats/group) were divided into four groups: control fed standard diet (STD) (3.82 kcal/g, 9.4% fat), CO-HFD (5.4 kcal/g, 40% fat), T1DM fed STD, and T1DM + CO-HFD. CO-HFD and T1DM alone or in combination impaired systolic and diastolic functions of rats and significantly reduced levels of GSH and the activity of SOD, enhanced lipid peroxidation, increased protein levels of P53, Bax, cleaved caspase-3, and ANF and decreased levels of Bcl-2 in their atria. Concomitantly, atrial cells exhibited fragmentation of the myofibrils, disorganized mitochondria, decreased number of atrionatriuretic factor (ANF) granules, and loss of gap junctions accompanied by changes in capillary walls. Among all treatments, the severity of all these findings was more severe in T1DM and most profound in the atria of T1DM + CO-HFD.In conclusion, chronic consumption of CO-HFD by T1DM-induced rats elicits significant biochemical and ultrastructural damage to rat atrial cells accompanied by elevated oxidative stress and mitochondria-mediated cell death.

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Effects of platelet rich plasma on experimentally induced diabetic heart injury

Hafez

Zenhom

Abdel-Hamid

2021

International Immunopharmacology

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Influence of Alpha-Lipoic Acid on Streptozotocin Induced Diabetic Cardiomyopathy in Adult Male Albino Rats

Cited by 4 publications

References 6 publications

Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats

Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats

Chronic consumption of a high‐fat diet rich in corn oil activates intrinsic cell death pathway and induces several ultrastructural changes in the atria of healthy and type 1 diabetic rat

Effects of platelet rich plasma on experimentally induced diabetic heart injury

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