In vivo assessment of safety and mechanisms underlying in vitro relaxation induced by Mikania laevigata Schultz Bip. ex Baker in the rat trachea

Graça, Carlos; Baggio, Cristiane Hatsuko; Freitas, Cristina Setim; Rattmann, Yanna Dantas; Souza, Lauro Mera de; Cipriani, Thales R.; Sassaki, Guilherme L.; Rieck, Lia; Pontarolo, Roberto; Silva-Santos, José Eduardo da; Marques, Maria Consuelo Andrade

doi:10.1016/j.jep.2007.03.026

Cited by 21 publications

(15 citation statements)

References 23 publications

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“…The coumarin seemed to be partially responsible for the bronchodilator activity of the plant through the relaxation of smooth muscle. In addition, Moura et al (2002) precontracted with acetylcholine with an effective concentration (EC50) of 1406.7 µg/ml and 1378.3 µg/ ml respectively, and a maximum effect (E max ) of 94.7 and 95.7% respectively (Graça et al, 2007; reviewed in Gasparetto et al, 2012). These data supports the indication that M. glomerata and M. laevigata can be used to treat bronchoconstrictive respiratory diseases.…”

Section: Activity In the Respiratory Tractmentioning

confidence: 99%

Genus Mikania: chemical composition and phytotherapeutical activity

Rufatto¹,

Gower²,

Schwambach³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The genus Mikania ranks high in the list of best-selling natural products in the world. Its main distribution is in South America, but some species are found in Asia, North America and Africa. It is used for treating fever, rheumatism, colds and respiratory diseases, as well as snake bites and scorpion stings, due to its broad spectrum of action. There are approximately 430 species of this genus and only 12% have been studied, highlighting their chemical and pharmacological diversity. The main chemical groups are: coumarins and derivatives, sesquiterpenes, sesquiterpenes lactones, diterpenes, phytosterols/terpenoids and flavonoids. This review aims to supply useful references for scientists interested in natural products and the search for new compounds, from over the 300 already described for the genus.

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Section: Activity In the Respiratory Tractmentioning

confidence: 99%

Genus Mikania: chemical composition and phytotherapeutical activity

Rufatto¹,

Gower²,

Schwambach³

et al. 2012

Rev. bras. farmacogn.

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“…Additionally, no evidence of toxicity in the hepatic, renal or pancreatic systems was reported. At reproductive endpoints, no alterations in body and organ weights, sperm, spermatid number, testosterone levels, or sperm morphology were observed after exposure to guaco syrup (Graca et al, 2007a(Graca et al, , 2007b. In humans, only two phase I clinical studies have been conducted to evaluate the clinical safety of guaco syrup.…”

Section: Toxicological Studiesmentioning

confidence: 99%

Mikania glomerata and M. laevigata: Clinical and Toxicological Advances

Gasparetto¹,

Pontarolo²,

Francisco³

et al. 2012

Toxicity and Drug Testing

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“…Adicionalmente, não houve alterações nas funções hepática, renal, pancreática e hematológicas em ratos machos e fêmeas (Graça et al, 2007b).…”

Section: Estudos Toxicológicosunclassified

“…Bras. IV, 2005. Tricoma glandular peltado e tricoma glandular unisseriado, com variável número de células na base e com célula terminal esférica ou espatulada são encontrados em depressão na epiderme, sendo este em maior frequência Lucas, 1942;Oliveira et al, 1984Oliveira et al, , 1985aOliveira et al, , 1993Oliveira et al, , 1994Vilegas et al, 1997;Veneziani et al, 1999;Fierro et al, 1999;Magalhães, 2000;Franchi, 2000;Cabral et al, 2001;Moura et al, 2002;Lima & Biasi, 2002;Castro, 2002;Yatsuda et al, 2005Costa et al, 2008;Silva et al, 2008. Cumarina; diidrocumarina; ácido o-cumárico Oliveira et al, 1984Oliveira et al, , 1994Biguetti, 1999;Magalhães, 2000;Lima & Biasi, 2002;Biavatti et al, 2004;Bighetti et al, 2005;Yatsuda et al, 2005;Santos et al, 2006;Graça et al, 2007b. Oliveira et al, 1984Oliveira et al, , 1985aOliveira et al, , 1993Oliveira et al, , 1994Oliveira et al, , 1999Vilegas et al, 1997;Veneziani et al, 1999;Fierro et al, 1999;Moura et al, 2002;Amaral et al, 2003;Yatsuda et al, 2005.…”

Section: Mikania Glomerataunclassified

Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae: estudos agronômicos, genéticos, morfoanatômicos, químicos, farmacológicos, toxicológicos e uso nos programas de fitoterapia do Brasil

Gasparetto¹,

Campos²,

Budel³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:No Brasil as espécies de Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae, popularmente conhecidas como guaco, são amplamente utilizadas com evidências pré-clínicas para o tratamento de doenças onde estejam envolvidas suas ações broncodilatadoras, antialérgicas, antiasmáticas, anti-inflamatórias, antiulcerogênicas e relaxantes da musculatura lisa. Em virtude das propriedades terapêuticas atribuídas as essas espécies, ambas foram oficializadas na farmacopéia brasileira, e por serem bastante semelhantes, dificilmente são diferenciadas. Com o objetivo de contribuir com novas pesquisas, a presente revisão descreve, de forma sistematizada, sobre os aspectos farmacológicos, toxicológicos, químicos, agronômicos, morfoanatômicos, genéticos e o uso nos programas de fitoterapia do Brasil destas espécies. As principais diferenças e semelhanças entre as duas espécies são evidenciadas através da comparação das informações baseadas na literatura específica.Unitermos: Asteraceae, Mikania glomerata, Mikania laevigata, guaco, plantas medicinais.ABSTRACT: "Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae: agronomic, genetic, anatomical, chemical, pharmacological, toxicological studies and its use in herbal therapy programs in Brazil." In Brazil the species of Mikania glomerata Spreng. and M. laevigata Sch. Bip. ex Baker, Asteraceae popularly known as guaco, are widely used with preclinical evidence for the treatment of diseases whose actions involve bronchodilators, antiallergic, anti-asthmatic, anti-inflammatory, antiulcerogenic and smooth muscles relaxant. Due to the therapeutic properties attributed to these species, both were included in the official Brazilian Pharmacopoeia, and because of their similarity, they are hardly differentiated. In order to contribute to the new research, this review describes their several aspects: pharmacology, toxicology, chemical, agricultural, anatomical, genetics and the use in herbal medicine programs in Brazil, in a systematic way. The main differences and similarities between the two species are evidenced by comparing the information based on literature.

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In vivo assessment of safety and mechanisms underlying in vitro relaxation induced by Mikania laevigata Schultz Bip. ex Baker in the rat trachea

Cited by 21 publications

References 23 publications

Genus Mikania: chemical composition and phytotherapeutical activity

Genus Mikania: chemical composition and phytotherapeutical activity

Mikania glomerata and M. laevigata: Clinical and Toxicological Advances

Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae: estudos agronômicos, genéticos, morfoanatômicos, químicos, farmacológicos, toxicológicos e uso nos programas de fitoterapia do Brasil

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