In vitro Evaluation of Oxidative Stress Caused by Fine Particles (PM2.5) Exhausted from Heavy-Duty Vehicles Using Diesel/Biodiesel Blends under Real World Conditions

Jesus, Robson M. de; Mosca, Aline C.; Guarieiro, Aline Lefol Nani; Rocha, Gisele O. da; Andrade, Jailson B. de

doi:10.21577/0103-5053.20170223

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…People can be exposed to nitro-PAHs from different sources. , For example, it has been reported that 1-nitronaphthalene and 2-nitronaphthalene are largely produced through smoking, while 1-nitropyrene, 2-nitrofluorene, and 9-nitrophenanthrene are mainly found in diesel exhaust. − In this study, 1-AP has a particularly strong association with 20-HETE, 11-dhTXB 2 , 8-OHdG, and aMT6s. In addition, 1-AN and 2-AN are significantly associated with 20-HETE, 8-OHdG, and aMT6s.…”

Section: Discussionmentioning

confidence: 59%

Nitrated Polycyclic Aromatic Hydrocarbons and Arachidonic Acid Metabolisms Relevant to Cardiovascular Pathophysiology: Findings from a Panel Study in Healthy Adults

Lin

Day³

et al. 2021

Environ. Sci. Technol.

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Concerns on nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) in the environment have mainly arisen from their mutagenic and carcinogenic effects. The objective of this study is to investigate whether nitro-PAH exposures are associated with biomarkers of cardiovascular pathophysiology. In a panel study design, urines and blood samples were collected up to four times with a 2-week interval from 89 healthy adults. We measured 1-naphthylamine, 2-naphthylamine, 9-aminophenanthrene, 2-aminofluorene, and 1-aminopyrene as biomarkers of nitro-PAH exposures. We measured three urinary metabolites of arachidonic acid (AA) including 20-hydroxyeicosatetraenoic acid (20-HETE) from the cytochrome P450 (CYP) pathway, 8-isoprostane from the nonenzymatic pathway, and 11-dehydro-thromboxane B2 (11-dhTXB2) from the cyclooxygenase (COX) pathway. Urinary malondialdehyde, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and 6-sulfatoxymelatonin (aMT6s) were measured to reflect systemic oxidative stress. Plasma concentrations of the soluble P-selectin and von Willebrand factor (vWF) were measured as biomarkers of platelet activation and endothelial dysfunction. We found that increased urinary concentrations of amino-PAHs were significantly associated with increased 20-HETE, 11-dhTXB2, and 8-OHdG and with decreased 8-isoprostane and aMT6s. Increased amino-PAHs were positively associated with P-selectin and vWF, respectively. These results suggest that exposure to nitro-PAHs increases systemic oxidative stress and alters AA metabolism toward CYP and COX pathways, leading to an increased cardiovascular disease risk.

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Section: Discussionmentioning

confidence: 59%

Nitrated Polycyclic Aromatic Hydrocarbons and Arachidonic Acid Metabolisms Relevant to Cardiovascular Pathophysiology: Findings from a Panel Study in Healthy Adults

Lin

Day³

et al. 2021

Environ. Sci. Technol.

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“…After observation using light microscopy, it appeared PM increased the fibroblast proliferation rate, however, mitochondrial changes cannot be discounted especially given the known oxidative properties of the PM mixture (Figure 3). 25 Fibroblasts also seemed to have decreased cytoplasmic volume, assuming a thinner, more spindle‐like morphology after PM exposure.…”

Section: Resultsmentioning

confidence: 99%

Exposing human primary dermal fibroblasts to particulate matter induces changes associated with skin aging

et al. 2020

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Global increases in air pollutant levels have always existed as a major health concern, however, it is only with research conducted in the last decade that new modes of action for these pollutants to harm have surfaced. Alongside the already established inhalation route, dermal absorption is now believed to be an additional route for various pollutants to enter internal systems and inflict damage, the mechanisms of which are now the focus of many research groups. 1,2 The World Health Organization (WHO) 2018 report states that 91% of the world's population live in areas where the air quality exceeds WHO air

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“…With regard to Hg directly emitted from the bus exhaustion, we considered samples collected in the bus station underground floor. In previous studies from the same research group, ,,,, , there are two main particle sources, the bus exhaustion and particle dust suspension from the floor derived from the buses either in the idle point (during waiting for passengers) or transiting within the station. In addition, it is virtually unlikely that there is any secondary process (i.e., particle aging or photochemical reactions) being undergoing modifying suspended particles in this bus station because our collection point was in the underground floor, where either natural or electric light is mostly absent.…”

Section: Resultsmentioning

confidence: 99%

Fine and Coarse Particle-Bound Mercury in (Bio)fuels and Biodiesel/Diesel Exhaust under Real World Circumstances

et al. 2020

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In order to better understand the role of Hg in the atmosphere, in this work, we investigated how much Hg is found in the Urban Dust reference material SRM1649b, in outdoor PM 2.5 and PM 10 samples, in samples freshly and directly emitted by heavy-duty vehicles, and in blended and unblended biodiesel and fossil diesel fuels (B0, B4, B7, B12, and B100). In the SRM1649b analysis, we found Hg at 1.75 ± 0.01 mg kg −1 , which is equivalent to more than 97.2% recovery when compared to the certified value. Particulate Hg in ambient samples was 1.82 ± 0.87 μg g −1 (site 3, Itaparica, ITA) to 9.11 ± 4.17 μg g −1 (site 1, Navy Base of Aratu, BNA) for PM 2.5 and 1.31 ± 0.89 μg g −1 (ITA) to 3.57 ± 1.25 μg g −1 (BNA), for PM 10 . In order to evaluate particulate Hg emissions under near real-life conditions, we collected PM 2.5 and PM 10 samples from an underground floor bus station. Total Hg levels for the bus station were 2.90 ± 1.15 μg g −1 for PM 2.5 and 2.19 ± 1.00 μg g −1 for PM 10 . Either in the bus station or ambient samples, we found that the PM 2.5 mass is about 60% of the PM 10 mass, which explains why particulate-bound Hg is mainly found in fine particles. With regard to fuels, the Hg levels were found to be B0 (0.83 μg kg −1 ), B4 (0.38 μg kg −1 ), B7 (0.50−1.10 μg kg −1 ), B12 (0.03−1.29 μg kg −1 ), and B100 (0.19 μg kg −1 ). Therefore, these results show that adding more biodiesel to diesel gradually decreases the Hg amount in the final blend. Risk assessment through inhalation was done for adults, adolescents, children, and infants. Although the highest daily inhalation exposure (DIE) values were observed for the bus station and the lowest DIE values were found to be from ITA, the risk levels are considered low.

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In vitro Evaluation of Oxidative Stress Caused by Fine Particles (PM2.5) Exhausted from Heavy-Duty Vehicles Using Diesel/Biodiesel Blends under Real World Conditions

Cited by 5 publications

References 36 publications

Nitrated Polycyclic Aromatic Hydrocarbons and Arachidonic Acid Metabolisms Relevant to Cardiovascular Pathophysiology: Findings from a Panel Study in Healthy Adults

Nitrated Polycyclic Aromatic Hydrocarbons and Arachidonic Acid Metabolisms Relevant to Cardiovascular Pathophysiology: Findings from a Panel Study in Healthy Adults

Exposing human primary dermal fibroblasts to particulate matter induces changes associated with skin aging

Fine and Coarse Particle-Bound Mercury in (Bio)fuels and Biodiesel/Diesel Exhaust under Real World Circumstances

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