“…Furthermore, we found that 11 upregulated genes ( cox2 , cox5b2 , cox6a1 , cox6b2 , cox6c , cox7a , cox7a2a , cox7c , cox8b , uqcrq , and uqcrh ) enriched in these three signaling pathways (cardiac muscle contraction, metabolic pathways, and oxidative phosphorylation pathway) (Figure A,C), are the cyclooxygenase (COX) subunits. A recent study reported that exposure to nitro-PAHs may increase oxidative stress, change the activity of the COX family, and adversely affect cardiovascular health . We found that DCBQ upregulated 7 genes ( al929536.3 , gstm.1 , gstm.3 , gsto2 , gstp1 , gstr , and gstt1b ) enriched in three signaling pathways: metabolic pathways, xenobiotics metabolism (cytochrome P450), and glutathione metabolism.…”