Improving oral bioavailability of acyclovir using nanoparticulates of thiolated xyloglucan

Madgulkar, Ashwini; Bhalekar, Mangesh R.; Dikpati, Amrita

doi:10.1016/j.ijbiomac.2016.02.007

Cited by 15 publications

(4 citation statements)

References 27 publications

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“…The prepared acyclovir nanoparticles have showed high drug entrapment and mucoadhesion. The in vitro drug release behavior indicated sustained release of acyclovir form nanoparticles over a period of 8 h. The in vivo study in rats indicated improvement in bioavailability of acyclovir compared to the marketed formulation [61] . Irinotecan [124] Oral nanoparticles Ionotropic gelation method, homogenization followed by lyophilization TG-SA (CaCl 2 ) Mucoadhesive NA…”

Section: Nanoparticlesmentioning

confidence: 92%

“…The thiolated derivative is white in color and water soluble with higher mucoadhesion than native TG. It was used in mucoadhesive topical delivery of metronidazole [60] , and oral delivery of acyclovir [61] and lopinavir [62] . Fig.…”

Section: Thiolation Of Tgmentioning

confidence: 99%

“…Acyclovir [61] Oral nanoparticles Mechanical stirring followed by lyophilisation Aminated TG (STMP) Mucoadhesive Rats…”

Section: Nanoparticlesmentioning

confidence: 99%

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Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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Tamarind seed polysaccharide is an emerging excipient, which is being used and investigated for the preparation of various dosage forms. Functionalization of tamarind gum (TG) enhances the properties of native tamarind polysaccharide like degradability, hydration, viscosity and swelling. Due to these excellent properties, researchers investigated the application of modified TG in various drug delivery systems. TG and modified TG are found to be appropriate for the designing of oral, nasal, ophthalmic, colonic and topical drug delivery systems. Moreover, they are used in the preparation of hydrogel-based drug delivery systems and novel drug delivery systems such as nanoparticles. Considering the above facts, additional research work is required to confirm the pharmaceutical uses of TG and modified TG in drug delivery. The current review deals with a comprehensive and valuable discussion on pharmaceutical applications of TG and modified TG.

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Section: Nanoparticlesmentioning

confidence: 92%

Section: Thiolation Of Tgmentioning

confidence: 99%

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Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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“…-Stable dosage forms of drugs which are either unstable (Alai and Lin, 2015;Bhadra et al, 2016) or have unacceptably low bioavailability in nonnanoparticulate dosage forms (Madgulkar et al, 2016;Ramalingam and Ko, 2016). (2) they control and sustain release of the drug during the transportation and at the site of localization (Behera and Sahoo, 2012), altering organ distribution of the drug and subsequent clearance of the drug so as to achieve increase in drug therapeutic efficacy and reduction in side effects (Kadam et al, 2012).…”

Section: The Advantages Of Using Nanoparticles As Drug Delivery System Includementioning

confidence: 99%

Review article on nanoemulsions and nanostructured lipid carriers

Faheim

Gardouh

Nouh

et al. 2018

Records of Pharmaceutical and Biomedical Sciences

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Lipid nanoparticles, including nanoemulsions (NEs) and nanostructured lipid carriers (NLCs) are colloidal carriers with a lipid matrix that is solid at body temperature. These colloidal carriers have attracted increasing interest for their use in therapeutic and cosmetic applications. The performance of lipid nanoparticle formulations is greatly influenced by their composition and structure. Lipid nanoparticles are generally composed of lipids, surfactants and co-surfactants. The lipid materials used in the production of lipid nanoparticles are usually solid at room temperature. Being well-tolerated in physiological conditions, lipid nanoparticles are typically biocompatible. Liquid lipids, or oils, are specifically used for production of NLCs. In most cases, lipid nanoparticles are produced as dispersions and surface-tailored with surfactants to improve dispersion stability. It was shown that NLCs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged half-life, and tissue-targeted delivery.

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