Antiviral and Antimicrobial (Antibacterial) Potentiality of Nano Drugs

Souza, Márcia Ebling de; Verdi, Camila Marina; Andrade, Eduardo N.C. de; Santos, Roberto C.V.

doi:10.1016/b978-0-12-814029-1.00012-0

Cited by 7 publications

(4 citation statements)

References 56 publications

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“…It used PNs functionalized with the Fc fragment of IgG to target neonatal Fc receptor (FcRn) through an FcRn-mediated transcytosis mechanism so the PNs can finally overstep the intestinal epithelium. Valuable information that may be of interest to the reader have also been reviewed elsewhere regarding nanotherapeutics of leishmaniasis [ 120 , 236 , 237 ], tuberculosis [ 238 , 239 , 240 , 241 , 242 ], viral infections [ 243 , 244 ], HIV [ 245 , 246 , 247 , 248 , 249 ], malaria [ 118 , 250 , 251 , 252 ], infectious diseases [ 4 , 45 , 66 , 253 ], intracellular delivery [ 59 , 60 , 64 , 83 , 254 , 255 ], bacterial pathogens [ 46 , 192 , 256 , 257 , 258 , 259 ] and stimuli-responsive systems [ 15 , 58 , 260 , 261 , 262 ].…”

Section: Recent Advances Of Pns In the Treatment Of Intracellular mentioning

confidence: 99%

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

2020

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Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat intracellular infections. They have outstanding performance in delivering antimicrobials intracellularly to reach an adequate dose level and improve their therapeutic efficacy. PNs offer opportunities for preventing unwanted drug interactions and degradation before reaching the target cell of tissue and thus decreasing the development of resistance in microorganisms. The use of PNs has the potential to reduce the dose and adverse side effects, providing better efficiency and effectiveness of therapeutic regimens, especially in drugs having high toxicity, low solubility in the physiological environment and low bioavailability. This review provides an overview of nanoparticles made of different polymeric precursors and the main methodologies to nanofabricate platforms of tuned physicochemical and morphological properties and surface chemistry for controlled release of antimicrobials in the target. It highlights the versatility of these nanosystems and their challenges and opportunities to deliver antimicrobial drugs to treat intracellular infections and mentions nanotoxicology aspects and future outlooks.

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Section: Recent Advances Of Pns In the Treatment Of Intracellular mentioning

confidence: 99%

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

2020

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“…According to the inhibitory zone diameters reported in Table , SDZ displayed antimicrobial activity against both bacteria, but its inhibitory effect was more pronounced on S. aureus , which is the second most common bacterium found in burn injuries . The antimicrobial activity of SDZ is due to the presence of both Ag + and sulfadiazine ions, which act in synergism, mainly on the base pairs of the DNA helix structure, inhibiting the microbial cell transcription process …”

Section: Resultsmentioning

confidence: 55%

“…To evaluate the SDZ release from the electrospun PLA nanofibers, a kinetic study was performed in phosphate buffer solution, as represented in Figure 5A. SDZ displays slow solubility in this medium; thus, its concentration increased gradually over time, as also observed in earlier reports (Figure 5A[1]).…”

Section: Resultsmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing

Malafatti

Bernardo

Moreira

et al. 2020

Polymers for Advanced Techs

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Poly(lactic acid) (PLA) is a versatile, bioabsorbable, and biodegradable polymer with excellent biocompatibility and ability to incorporate a great variety of active agents. Silver sulfadiazine (SDZ) is an antibiotic used to control bacterial infection in external wounds. Aiming to combine the properties of PLA and SDZ, hydrotalcite ([Mg-Al]-LDH) was used as a host matrix to obtain an antimicrobial system efficient in delivering SDZ from electrospun PLA scaffolds intended for wound skin healing. The structural reconstruction method was successfully applied to intercalate silver sulfadiazine in the [Mg-Al]-LDH, as evidenced by X-ray diffraction and thermogravimetric analyses. Observations by scanning electron microscopy revealed a good distribution of SDZ-[Mg-Al]-LDH within the PLA scaffold. Kinetics studies revealed a slow release of SDZ from the PLA scaffold due to the intercalation in the [Mg-Al]-LDH. In vitro antimicrobial tests indicated a significant inhibitory effect of SDZ-[Mg-Al]-LDH against Escherichia coli and Staphylococcus aureus. This antibacterial activity was sustained in the 2.5-wt% SDZ-[Mg-Al]-LDH-loaded PLA nanofibers, which also displayed excellent biocompatibility towards human cells. The multifunctionality of the PLA/SDZ-[Mg-Al]-LDH scaffold reported here is of great significance for various transdermal applications. K E Y W O R D S drug release, electrospinning, hydrotalcite, sulfadiazine silver, wound healing

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“…Continuing efforts are needed to develop more effective strategies, particularly for critically ill patients suffering from severe infectious diseases. To curb emerging infectious diseases, it is important to develop effective strategies for prevention and treatment of causing agent persistence in immune-privileged sites, proper optimization of postexposure prophylaxis, and to increase therapeutic breadth by discovering newer antibiotics or using promising strategies like nanotechnology, nanotheranostics, targeted delivery systems for attacking the disease-causing parasites present in cells effectively without producing adverse effects [69] , [70] .…”

Section: Current Scenario and Future Perspectivesmentioning

confidence: 99%