Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali, Kailas K.; Dhawale, Shashikant C.; Dias, Remeth J.; Ghorpade, Vishwajeet Sampatrao

doi:10.21608/bfpc.2019.47260

Cited by 13 publications

(6 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several substances find a perfect home in it. When exposed to warm water, it forms a thick gel and is almost entirely insoluble in organic solvents [10]. This gum has been used to create many carrier systems for medication administration via the mouth, nose, eyes, and intestines.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Tamarind Gum-β-Cyclodextrin-g-Poly(Methacrylate) pH-Responsive Hydrogels for Sustained Delivery of Acyclovir

Shafiq

Mahmood²,

Salem‐Bekhit³

et al. 2022

Pharmaceuticals

View full text Add to dashboard Cite

Acyclovir has a short half-life and offers poor bioavailability. Its daily dose is 200 mg five times a day. A tamarind gum and β-cyclodextrin-based pH-responsive hydrogel network for sustained delivery of acyclovir was developed using the free-radical polymerization technique. Developed networks were characterized by FTIR, DSC, TGA, PXRD, EDX, and SEM. The effect of varying feed ratios of polymers, monomers, and crosslinker on the gel fraction, swelling, and release was also investigated. FTIR findings confirmed the compatibility of the ingredients in a new complex polymer. The thermal stability of acyclovir was increased within the newly synthesized polymer. SEM photomicrographs confirmed the porous texture of hydrogels. The gel fraction was improved (from 90.12% to 98.12%) with increased reactant concentrations. The pH of the dissolution medium and the reactant contents affected swelling dynamics and acyclovir release from the developed carrier system. Based on the R2 value, the best-fit model was zero-order kinetics with non-Fickian diffusion as a release mechanism. The biocompatibility of the developed network was confirmed through hematology, LFT, RFT, lipid profile, and histopathological examinations. No sign of pathology, necrosis, or abrasion was observed. Thus, a pH-responsive and biocompatible polymeric system was developed for sustained delivery of acyclovir to reduce the dosing frequency and improve patient compliance.

show abstract

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Tamarind Gum-β-Cyclodextrin-g-Poly(Methacrylate) pH-Responsive Hydrogels for Sustained Delivery of Acyclovir

Shafiq

Mahmood²,

Salem‐Bekhit³

et al. 2022

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…ATG is compatible with common excipients and can be easily processed. [14][15][16][17][18] Overall, the use of ATG in solid dispersions provides a flexible solution to problems with solubility and enhances drug delivery. We have performed this effort to use the ATG in the solid dispersion with higher solubilities and dissolutions through fastdissolving tablets in light of all these potential benefits of the ATG.…”

Section: Introductionmentioning

confidence: 99%

Development of Fast Release Aminated Tamarind Gum Carrier-based Solid Dispersion containing Tablets of Ketoconazole for Solubility and Dissolution Rate Enhancement

Velhal,

Salunkhe

2023

IJDDT

View full text Add to dashboard Cite

This work enhances the solubility as well as dissolution of the biopharmaceutical classification system (BCS) II drug ketoconazole (KTZ) using fast-dissolving tablets that contain solid aminated tamarind gum (ATG). In the first stage amination of the tamarind gum was done to form ATG and which was confirmed by the presence of characteristic peaks using Fourier-transform infrared spectroscopy (FTIR). DSC-TGA analysis showed a weight loss with 3.91% at 100℃, 54.42% loss at 235 to 425℃ and 90% at 485℃. The proton nuclear magnetic resonance (1H-NMR) showed all resonance peaks observed in ATG. The XRD analysis of ATG confirmed the amorphous nature of the material. The second phase involved developing KTZ-loaded solid dispersion (SD) using the kneading process. KTZ SD showed drug content of 94.55 to 97.21%. SD of KTZ manufactured with TG showed 2.55 to 23.82-fold solubility enhancement in water while in case of SD with ATG showed 28.51 to 33.19-fold solubility enhancement. KTZ had a 32% dissolution rate in the pure drug sample, but the SD5 formulation showed a complete release of solid dispersion in 120 minutes. In FTIR, the disappearance of the peak signifies the production of solid dispersion and the drug’s transformation from a crystalline to an amorphous state. Powder X-ray diffraction (PXRD) analysis of solid dispersions reveals a notable decline in crystallinity, as shown by the removal of strong, distinguishing peaks. The scanning electron microscope (SEM) analysis confirmed the successful development of the SD in which KTZ was observed to be dispersed in a polymeric carrier. Optimized KTZ-loaded SD were utilized in fast-dissolving tablets as the third phase. When compared to the drug release achieved from solid dispersions, it was discovered that the dissolving characteristics of all formulation batches were improved.

show abstract

“…The carboxymethylation of gum was done so, as to enhance the disintegration property whereas calcium complexation enhances the absorption ability of the gum. This would result in the rapid release and disintegration of tablets [10,11].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Fast Disintegrating Tablet of Propranolol Hydrochloride Using Modified Tamarind Seed Gum as a Natural Superdisintegrant

Rani

Dev

2022

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The present study was carried out for the preparation of modified Tamarindus indica seed gum as a natural superdisintegrant and assessed various parameters for preparing a fast disintegrating dosage form. Methods: The extracted gum from tamarind seeds was chemically modified by the carboxymethylation method. Then, calcium complexation of carboxymethyled tamarind seed gum was done. Fast disintegrating tablets were prepared by the direct compression method. The change in the functional groups of the extracted gum, Carboxymethyl tamarind seed gum, and the calcium complexed tamarind seed gum was studied by FT-IR spectrophotometer. DSC studies of calcium complexed tamarind seed gum showed alterations in the melting point without undergoing any modification. Results: The pre-formulation studies such as physical appearance, swelling index, and viscosity of calcium complexed tamarind seed gum were characterized. From the studies, it was concluded that modified Tamarind seed gum was acidic and hydrophilic. The pH of the extracted tamarind seed gum was found to be 5.4. The fast disintegrating tablets were evaluated for hardness, friability, disintegration time, thickness, and in-vitro dissolution study. In the present study, the disintegration time of calcium complexed tamarind seed gum-containing tablets was compared with the marketed formulation of croscarmellose sodium as a synthetic superdisintegrant. The F5 formulation of calcium complexed tamarind seed gum showed a disintegration time of 37±2 s whereas the marketed formulation of croscarmellose sodium showed a disintegration time of 48±2 s. Conclusion: It can be concluded that a fast disintegrating tablet prepared using calcium complexed Tamarind seed gum improves the disintegration time of the tablet.

show abstract

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Cited by 13 publications

References 127 publications

Development and Optimization of Tamarind Gum-β-Cyclodextrin-g-Poly(Methacrylate) pH-Responsive Hydrogels for Sustained Delivery of Acyclovir

Development and Optimization of Tamarind Gum-β-Cyclodextrin-g-Poly(Methacrylate) pH-Responsive Hydrogels for Sustained Delivery of Acyclovir

Development of Fast Release Aminated Tamarind Gum Carrier-based Solid Dispersion containing Tablets of Ketoconazole for Solubility and Dissolution Rate Enhancement

Formulation and Evaluation of Fast Disintegrating Tablet of Propranolol Hydrochloride Using Modified Tamarind Seed Gum as a Natural Superdisintegrant

Contact Info

Product

Resources

About