Review article on nanoemulsions and nanostructured lipid carriers

Abstract

Lipid nanoparticles, including nanoemulsions (NEs) and nanostructured lipid carriers (NLCs) are colloidal carriers with a lipid matrix that is solid at body temperature. These colloidal carriers have attracted increasing interest for their use in therapeutic and cosmetic applications. The performance of lipid nanoparticle formulations is greatly influenced by their composition and structure. Lipid nanoparticles are generally composed of lipids, surfactants and co-surfactants. The lipid materials used in the production of lipid nanoparticles are usually solid at room temperature. Being well-tolerated in physiological conditions, lipid nanoparticles are typically biocompatible. Liquid lipids, or oils, are specifically used for production of NLCs. In most cases, lipid nanoparticles are produced as dispersions and surface-tailored with surfactants to improve dispersion stability. It was shown that NLCs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged half-life, and tissue-targeted delivery.

Entacapone Nanoemulsion: Formulation Design, Optimization, and Evaluation

“…The synthesized formulation's zeta potential was discovered to be -20.6 0.8 mV. If stabilized by a single mechanism, nanoformulations with a zeta potential of 30 mV are regarded as stable; if stabilized by a combination of these two mechanisms, they have a zeta potential of 20 mV [37]. Because there were multiple mechanisms at work to stabilize the created nanoemulsion, a zeta potential of roughly 20 mV might offer adequate stability.…”