Improved HPLC method for determining brodifacoum in animal tissues

Hoogenboom, J.J.L.; Rammell, C. G.

doi:10.1007/bf01607900

Cited by 17 publications

(10 citation statements)

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“…An early, interesting approach was to use a post-column pH shift to enhance fluorescence detection (Hunter, 1983(Hunter, , 1985. Several earlier HPLC methods have also been reported (AOAC, 1976a,b;Mundy and Machin, 1982;Hunter, 1983): diphacinone (Bullard et al, 1975(Bullard et al, , 1976, fluorescence for bromadiolone (Deepa and Mishra, 2005), brodifacoum (Fu et al, 2006), brodifacoum in tissues (Hoogenboom and Rammell, 1983), difenacoum (Hadler and Shadbolt, 1975), determination of Rozol in parafinized formulations (Kawano and Chang, 1980), and bromadiolone in tissues (Nahas, 1986).…”

Section: Methodsmentioning

confidence: 96%

“…Early HPLC methods focused on an individual chemical. For example, methods to detect chlorophacinone in formulations (Grant and Pike, 1979;Vigh et al, 1981), brodifacoum in serum (Murphy and Gerken, 1989), brodifacoum (Koubek et al, 1979;Keiboom and Rammel, 1981;Hoogenboom and Rammell, 1983;Ray et al, 1989), bromadiolone (Hunter, 1983;Subbiah et al, 2005), chlorophacionone (Hunter, 1985), difethiolone (Goldade et al, 1998), and difenacoum (Mundy and Machin, 1977) in tissue have been reported.…”

Section: Methodsmentioning

confidence: 97%

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Superwarfarins

Murphy¹,

Lugo²

2015

Handbook of Toxicology of Chemical Warfare Agents

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Section: Methodsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 97%

Superwarfarins

Murphy¹,

Lugo²

2015

Handbook of Toxicology of Chemical Warfare Agents

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“…[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], 11 had lost their transmitter (along with the central tail feathers in 10 cases) and radio contact was lost with 3 others (Table 1). [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], 11 had lost their transmitter (along with the central tail feathers in 10 cases) and radio contact was lost with 3 others (Table 1).…”

Section: Screech-o Wl Mortalitymentioning

confidence: 99%

“…Of the remaining 15 screech-owls captured (Nos. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], 11 had lost their transmitter (along with the central tail feathers in 10 cases) and radio contact was lost with 3 others (Table 1). At least 11 of these birds were located by radiotelemetry in brodifacoum-treated areas posttreatment.…”

Section: Screech-o Wl Mortalitymentioning

confidence: 99%

Potential Hazard to Eastern Screech-Owls and Other Raptors of Brodifacoum Bait Used for Vole Control in Orchards

Hegdal

Colvin

1988

Environ Toxicol Chem

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During the fall and winter of 1981–82, a study was conducted to evaluate the secondary poisoning hazards associated with a proposed anticoagulant rodenticide, Volid® (10 ppm brodifacoum), when used to control voles (Microtus spp.) in apple orchards. Radio transmitters were attached to 38 eastern screech‐owls (Otus asio), 5 barred owls (Strix varia), 3 red‐tailed hawks (Buteo jamaicensis), 2 great horned owls (Bubo virginianus) and 2 long‐eared owls (Asio otus), and the birds' movements were monitored before, during, and after rodenticide applications. Screech‐owls selected woods over alternate habitats for day‐roosting; 73% of daytime locations were in woods. At night, screech‐owls generally were located in woods, orchard, and field‐pasture proportional to their availability, while they avoided cropland. The home ranges of 32 screech‐owls tracked posttreatment included brodifacoum‐treated areas; the proportion of home range treated and habitat use varied among individuals. Minimum mortality was 58% among screech‐owls for which more than 20% of home range was treated, as compared with 17% among those for which less than 10% of home range was treated. Secondary brodifacoum poisoning was the most probable cause of death in six screech‐owls. Of five other screech‐owls found dead posttreatment, four had been consumed by predators and one died of unknown causes. Of six radio‐equipped screech‐owls collected one to two months posttreatment, four contained detectable brodifacoum residue. The fate of 14 of the 32 screech‐owls tracked posttreatment was unknown at the conclusion of radiotracking efforts (63 d after treatment began) because radio contact was lost or the transmitter was dropped; one of these owls was encountered alive in May. Four barred owls tracked posttreatment showed strong selection for woodland habitat and used orchards limitedly; none was found dead posttreatment. One long‐eared owl found dead (not radio‐equipped) was probably killed by secondary brodifacoum poisoning. The results indicate a hazard to screech‐owls and a potential risk to other raptors, given this use pattern and formulation of brodifacoum bait.

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“…A number of HPLC methods have been described for the determination of individual coumarin-based anticoagulants in biological materials including methods for warfarin (Mundy et al 1976, Lee et al 1981, de Vries et al 1993, difenacoum (Mundy et al 1977, Kelly et al 1993) and brodifacoum (Koubek et al 1979, Kieboom et al 1981, Hogenboom et al 1983). Multiresidue methods have also been described: Mundy and Machin (1982) used HPLC to determine four coumarin anticoagulants, but difenacoum, brodifacoum and coumatetralyl were not resolved and had to be identified by further HPLC analysis of the fractions from the column.…”

mentioning

confidence: 99%

HPLC Determination of Anticoagulant Rodenticide Residues in Animal Livers

Jones¹

1996

Bull. Environ. Contam. Toxicol.

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Improved HPLC method for determining brodifacoum in animal tissues

Cited by 17 publications

References 1 publication

Superwarfarins

Superwarfarins

Potential Hazard to Eastern Screech-Owls and Other Raptors of Brodifacoum Bait Used for Vole Control in Orchards

HPLC Determination of Anticoagulant Rodenticide Residues in Animal Livers

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