<i>Interleukin-10</i>gene polymorphisms and hepatocellular carcinoma susceptibility: A meta-analysis

Yue, Wei; Liu, Fei; Li, Bo; Chen, Xi; Ma, Yu; Yan, Lvnan; Wen, Tianfu; Xu, Mingqing; Wang, Wentao; Yang, Jiayin

doi:10.3748/wjg.v17.i34.3941

Cited by 32 publications

(26 citation statements)

References 49 publications

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“…Shin et al (2003) reported that upregulated IL-10 accelerates the progression of chronic HBV infection in a Korean population, particularly in HCC development. A recent meta-analysis of 1012 HCC cases and 2308 controls indicated that a polymorphism of IL-10-592 A/C was associated with HBV and HCC, but no association was found between IL-10-1082 G/A and IL-10-819 T/C polymorphisms and the risk of HCC (Wei et al, 2011). Another meta-analysis reported that IL-10-1082 G/A polymorphisms were related to the risk of HCC (Yang et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Sofian et al (2013) reported that IL-10 promoter polymorphisms were not associated with HBV infection, and the A/A genotype at position -592 and the T/T genotype at position -819 were more frequently observed in patients with HBV. Moreover, IL-10 mRNA polymorphisms are associated with hepatocellular carcinoma, particularly in HBV-and HCVinfected individuals (Shin et al, 2003;Wang et al, 2006;Yang et al, 2011;Wei et al, 2011). Shin et al (2003) reported that upregulated IL-10 accelerates the progression of chronic HBV infection in a Korean population, particularly in HCC development.…”

Section: Discussionmentioning

confidence: 99%

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Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis

Liu

Zhang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We conducted a hospital-based case-control study to assess the association between IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G polymorphisms and the risk of liver cirrhosis in a Chinese population. This 1:1-matched case-control study included 192 patients from the Chinese PLA General Hospital. Genotypes of IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G were detected by polymerase chain reaction amplification-restriction fragment length polymorphism analysis. Conditional regression analysis showed that individuals carrying the IL-10-1082 G allele had an only slightly increased risk of liver cirrhosis, with an adjusted odds ratio (95% confidence interval) of 2.14 (0.97-1.68). However, we did not identify a significant association between polymorphisms in IL-10-592 A/C and IL-10-819 C/T and the risk of liver cirrhosis. These findings may provide important clues for future studies of early detection screening of liver cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis

Liu

Zhang

et al. 2015

Genet. Mol. Res.

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“…This single base pair substitution has been named both -819C/T and rs1800871. At this time, a series of seven molecular epidemiological studies and metaanalyses have investigated the association between the IL-10 -819C/T polymorphism and the susceptibility to different cancer types among different populations (Chen et al, 2010;Persson et al, 2011;Shao et al, 2011;Wei et al, 2011;Xue et al, 2012;Zou et al, 2011). However, the results from these studies are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

The Interleukin 10 −819C/T Polymorphism and Cancer Risk: A HuGE Review and Meta-Analysis of 73 Studies Including 15,942 Cases and 22,336 Controls

Liu²,

Huang

et al. 2013

OMICS: A Journal of Integrative Biology

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The aim of the present work was to perform a meta-analysis to evaluate the association between the interleukin 10 (IL-10) -819C/T (rs1800871) polymorphism and cancer risk. A total of 73 studies, including 15,942 cancer cases and 22,336 controls, were identified in this meta-analysis. The odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the random-effects model. Overall, no significant association was identified between the IL-10 -819C/T polymorphism and cancer risk. In the subgroup analyses, the T allele and TT genotype were associated with a moderately reduced cancer risk in the Asian population (T allele vs. Individuals who were homozygous for the T allele (TT) were found to be associated with significantly reduced gastric cancer risk in the Asian population. The heterozygous variant (CT) and the dominant model (TT/CT vs. CC) were associated with an increased risk for cervical and ovarian cancer. However, the IL-10 -819C/T polymorphism was not significantly associated with breast cancer, colorectal cancer, lung cancer, hepatocellular carcinoma, prostate cancer, lymphoma, or melanoma. The depressed cancer risk of the TT genotype occurred in the studies of hospital-based case-control studies and the studies recruited less than 500 subjects, but no statistically significant results were found in the stratified analyses using genotyping method. The results suggest that the IL-10 -819TT genotype may be a protective factor for cancer in Asians, especially gastric cancer. In contrast, the CT genotype and the dominant model could be risk factors for cervical and ovarian cancer. The importance of stratifying by ethnicity, cancer type, study design, and sample size needs to be standardized in future studies, together with considering the association between the IL-10 -819C/T polymorphism and cancer risk. Furthermore, the linkage of -819C/T with other polymorphisms of the IL-10 gene may help explain the variability in findings.

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“…Yang and Fa (2015) indicated that IL-10 -1082A/G constitutes a candidate biomarker for the prediction of susceptibility to esophageal cancer, while Vinod et al (2015) suggested that the AA genotype of this SNP correlates with breast cancer oncogenesis in the South Indian population. Several previous studies have examined the association between IL-10 gene polymorphisms and development of HCC (Ben-Ari et al, 2003;Heneghan et al, 2003;Tseng et al, 2006;Truelove et al, 2008;Qiu et al, 2011;Wei et al, 2011). Tseng et al (2006) demonstrated that the -592G/A variant affects HCC risk, while Qiu et al (2011) reported that certain genotypes of the -819 and -592 SNPs increase and decrease susceptibility, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…It is therefore reasonable to consider the IL-10 gene a candidate factor in cancer susceptibility. Previous studies have examined associations between IL-10 polymorphisms and HCC risk, but with inconclusive results (Tseng et al, 2006;Wang et al, 2006;Truelove et al, 2008;Wei et al, 2011;Yu et al, 2013). Therefore, we conducted a case-control study to investigate the role of three common IL-10 single nucleotide polymorphisms (SNPs; -592G/A, -819T/C, and -1082A/C) in the development of HBV-related HCC.…”

Section: Introductionmentioning

confidence: 99%

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

Liu

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/ C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain reaction-restriction fragment length polymorphism assay was applied to assess the sequence variants of interest. Compared with control subjects, HCC patients were more likely to be older (t = 1.94, P = 0.03), have a family history of cancer (chi square = 17.86, P < 0.001), and exhibit higher alanine transaminase (t = 13.32, P < 0.001) and aspartate transaminase (t = 12.63, P < 0.001) levels. Using unconditional logistic regression analyses, we found that the GG genotype of -592G/A was associated with increased risk of HCC [odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.12-4.38], compared to the AA genotype. Under a dominant model, the AG+GG genotype correlated with HBV-related HCC susceptibility compared to the AA genotype, with an OR (95%CI) of 1.56 (1.02-2.48). Moreover, a recessive model showed the GG genotype to be associated with elevated risk of HCC compared to the AA+AG genotype (OR = 1.85, 95%CI = 1.01-3.47). However, no significant association between the -819T/C and -1082A/C variants and development of HBV-related HCC was observed under codominant, dominant, and recessive models. We conclude that the IL-10 -592G/A polymorphism does play a role in susceptibility to HBV-related HCC under codominant, dominant, and recessive models.

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Interleukin-10gene polymorphisms and hepatocellular carcinoma susceptibility: A meta-analysis

Abstract: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC.

Cited by 32 publications

References 49 publications

Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis

Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis

The Interleukin 10 −819C/T Polymorphism and Cancer Risk: A HuGE Review and Meta-Analysis of 73 Studies Including 15,942 Cases and 22,336 Controls

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

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