Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

Abstract

ABSTRACT. We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/ C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain reaction-restriction fragment length polymorphism assay was applied to assess the sequence variants of interest. Compared with control subjects, HCC patients were more likely to be older (t = 1.94, P = 0.03), have a family history of cancer (chi square = 17.86, P < 0.001), and exhibit higher alanine transaminase (t = 13.32, P < 0.001) and aspartate transaminase (t = 12.63, P < 0.001) levels. Using unconditional logistic regression analyses, we found that the GG genotype of -592G/A was associated with increased risk of HCC [odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.12-4.38], compared to the AA genotype. Under a dominant model, the AG+GG genotype correlated with HBV-related HCC susceptibility compared to the AA genotype, with an OR (95%CI) of 1.56 (1.02-2.48). Moreover, a recessive model showed the GG genotype to be associated with elevated risk of HCC compared to the AA+AG genotype (OR = 1.85, 95%CI = 1.01-3.47). However, no significant association between the -819T/C and -1082A/C variants and development of HBV-related HCC was observed under codominant, dominant, and recessive models. We conclude that the IL-10 -592G/A polymorphism does play a role in susceptibility to HBV-related HCC under codominant, dominant, and recessive models.

Association of CTLA‐4, TNF alpha and IL 10 polymorphisms with susceptibility to hepatocellular carcinoma

“…This is consistent with previous studies, but contradicts that reported in other works. 31,32 These inconsistent results may be partly due to small sample sizes, racial and ethnic differences, and publication bias.…”

Association of three promoter polymorphisms in interleukin-10 gene with cancer susceptibility in the Chinese population: a meta-analysis

“…Ultimately, 53 articles were included in the final meta-analysis. Of these 53 articles, 24 articles [ 40 – 63 ] include 26 studies examining IL-10 -1082A/G polymorphism, 28 articles [ 18 , 42 , 43 , 45 , 47 , 49 , 52 , 53 , 57 - 61 , 63 - 77 ] include 33 studies examining the -819T/C polymorphism, and 39 articles [ 18 , 42 , 43 , 45 , 47 , 52 , 53 , 56 - 67 , 69 , 70 , 73 - 76 , 78 - 91 ] include 42 studies examining the -592A/C polymorphism (Table 1 ). Of the 53 articles, two publications [ 18 , 45 ] with three cancer types were considered as three studies and one publication [ 65 ] with two cancer types were also considered as two studies.…”

“…As regards the -1082A/G polymorphism, five studies focused on gastric cancer [ 40 , 44 , 47 , 52 , 56 ], three on hepatocellular carcinoma [ 41 , 49 , 63 ], two studies for each of the following cancer types, such as lung cancer [ 42 , 46 ], cervical cancer [ 51 , 61 ] and esophageal cancer [ 55 , 60 ], and the other cancer types with one study per each cancer type. As regards the -819T/C polymorphism, 10 studies focused on gastric cancer [ 18 , 47 , 52 , 64 , 65 , 68 , 70 , 72 , 73 , 77 ], four on hepatocellular carcinoma [ 18 , 49 , 63 , 69 ], three on esophageal cancer [ 18 , 60 , 65 ], two studies for each of the following cancer types, such as lung cancer [ 42 , 75 ], oral cancer [ 59 , 66 ] and acute myeloid leukemia [ 58 , 74 ], and the other cancer types with one study per each cancer type. As regards the -592A/C polymorphism, 11 studies focused on gastric cancer [ 18 , 47 , 52 , 56 , 64 , 65 , 70 , 73 , 87 , 89 , 91 ], five on hepatocellular carcinoma [ 18 , 63 , 69 , 78 , 85 ], four studies for each of the following cancer types, such as lung cancer [ 42 , 75 , 80 , 86 ] and esophageal cancer [ 18 , ...…”

“…As regards the -819T/C polymorphism, 10 studies focused on gastric cancer [ 18 , 47 , 52 , 64 , 65 , 68 , 70 , 72 , 73 , 77 ], four on hepatocellular carcinoma [ 18 , 49 , 63 , 69 ], three on esophageal cancer [ 18 , 60 , 65 ], two studies for each of the following cancer types, such as lung cancer [ 42 , 75 ], oral cancer [ 59 , 66 ] and acute myeloid leukemia [ 58 , 74 ], and the other cancer types with one study per each cancer type. As regards the -592A/C polymorphism, 11 studies focused on gastric cancer [ 18 , 47 , 52 , 56 , 64 , 65 , 70 , 73 , 87 , 89 , 91 ], five on hepatocellular carcinoma [ 18 , 63 , 69 , 78 , 85 ], four studies for each of the following cancer types, such as lung cancer [ 42 , 75 , 80 , 86 ] and esophageal cancer [ 18 , 60 , 65 , 83 ], three on cervical cancer [ 61 , 79 , 81 ], two studies for each of the following cancer types, such as nasopharyngeal carcinoma [ 43 , 84 ], oral cancer [ 59 , 66 ], acute myeloid leukemia [ 58 , 74 ] and colorectal cancer [ 62 , 88 ], and the other cancer types with one study per each cancer type. Among all studies, 18 were hospital-based and eight were pop...…”