The Interleukin 10 −819C/T Polymorphism and Cancer Risk: A HuGE Review and Meta-Analysis of 73 Studies Including 15,942 Cases and 22,336 Controls

Abstract

The aim of the present work was to perform a meta-analysis to evaluate the association between the interleukin 10 (IL-10) -819C/T (rs1800871) polymorphism and cancer risk. A total of 73 studies, including 15,942 cancer cases and 22,336 controls, were identified in this meta-analysis. The odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the random-effects model. Overall, no significant association was identified between the IL-10 -819C/T polymorphism and cancer risk. In the subgroup analyses, the T allele and TT genotype were associated with a moderately reduced cancer risk in the Asian population (T allele vs. Individuals who were homozygous for the T allele (TT) were found to be associated with significantly reduced gastric cancer risk in the Asian population. The heterozygous variant (CT) and the dominant model (TT/CT vs. CC) were associated with an increased risk for cervical and ovarian cancer. However, the IL-10 -819C/T polymorphism was not significantly associated with breast cancer, colorectal cancer, lung cancer, hepatocellular carcinoma, prostate cancer, lymphoma, or melanoma. The depressed cancer risk of the TT genotype occurred in the studies of hospital-based case-control studies and the studies recruited less than 500 subjects, but no statistically significant results were found in the stratified analyses using genotyping method. The results suggest that the IL-10 -819TT genotype may be a protective factor for cancer in Asians, especially gastric cancer. In contrast, the CT genotype and the dominant model could be risk factors for cervical and ovarian cancer. The importance of stratifying by ethnicity, cancer type, study design, and sample size needs to be standardized in future studies, together with considering the association between the IL-10 -819C/T polymorphism and cancer risk. Furthermore, the linkage of -819C/T with other polymorphisms of the IL-10 gene may help explain the variability in findings.

Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study

“…However, Ozbas-Gerceker et al reported that LMP2 plays a role in the development of acute myeloid leukemia and multiple myeloma, whereas LMP7 is not a risk factor for hematological malignancies (24). The discrepancy between these results and the present findings may be attributed to the fact that the same polymorphism may exert different genetic effects on various types of cancer (25,26).…”

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

“…The racial differences, number of patients enrolled them age, diagnosis, study design may contribute the differences in the results (Kang et al, 2009). Some recently meta-analysis have been shown that IL-10 -819TT genotype may be a protective factor for gastric cancer in Asians (Yu et al, 2013). Moreover study from China has been demonstrated that the IL-10-592 polymorphism is associated with protective effect in non-cardia gastric cancer (Pan et al, 2013).…”

Genetic Polymorphism of Interleukin-1A (IL-1A), IL-1B, and IL-1 Receptor Antagonist (IL-1RN) and Prostate Cancer Risk

“…Therefore, it is reasonable to assume that sequence variants in genes coding proinflammatory and anti-inflammatory cytokines influence PCa risk, since cytokine gene polymorphisms may lead to an altered production of cytokines (Hollegaard and Bidwell, 2006). Meta-analyses have been performed about the association between polymorphisms of proinflammatory [IL-6, IL-8, and tumor necrosis factor-α (TNF-α)] Ma et al, 2014;Yang et al, 2014) and anti-inflammatory (IL-10) (Yu et al, 2013) cytokines and PCa risk. Another proinflammatory cytokine, IL-1, though important in inflammation, was not fully examined about its role in the development of PCa.…”

“…IL-10 is the most studied IL in the context of IL variants and PCa risk. Most studies have inconsistent results, and the most recent meta-analysis showed that IL-10 (rs1800871) polymorphism was not significantly associated with PCa (Yu et al, 2013). However, another meta-analysis suggested that IL-10 (rs1800871) and IL-10 (rs1800872) polymorphisms might be modestly associated with advanced PCa and might therefore impact disease progression (Shao et al, 2011).…”