Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Kulmambetova, G.N.; Imanbekova, M.K.; Logvinenko, Andrey Alexeevich; Сукашев, А.Т.; Филипенко, М. Л.; Ramanculov, Erlan

doi:10.7314/apjcp.2014.15.18.7763

Cited by 23 publications

(15 citation statements)

References 34 publications

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“…Consequently, in order to articulate the roles of A2M in metastatic OS, we performed PPI network and identified its interactive proteins, for instance, IL1B, LRP1 and PDGF. IL1B encodes the proinflammatory cytokine IL-1β with multiple biological effects (Lee et al, 2003), and represents the potential effects in the gastric cancer (Kulmambetova et al, 2014). Very recent study also confirms that the genetic polymorphisms of IL1B are strongly associated with OS risk (He et al, 2014).…”

Section: Discussionsupporting

confidence: 52%

Identification and Functional Analysis of Differentially Expressed Genes Related to Metastatic Osteosarcoma

Niu

Zhao²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 52%

Identification and Functional Analysis of Differentially Expressed Genes Related to Metastatic Osteosarcoma

Niu

Zhao²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…The IL-1 receptor antagonist gene polymorphism has been linked with a wide variety of diseases in the literature. Its association with preeclampsia, psoriasis, asthma, sepsis, inflammatory bowel disease, systemic lupus erythematosus, gastritis, schizophrenia, intellectual disability, cervical cancer, and even tonsillar hypertrophy has been studied recently [13][14][15][16][17][18][19]. The correlation between the IL-1 RN gene polymorphism and asthma has been demonstrated by various studies from Turkey, Egypt, South Africa, northern India, and Japan [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis

Kuran¹,

Aslan²,

Haytoğlu³

et al. 2019

Turk J Med Sci

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Background/aim: Sinonasal polyposis is a complex chronic disease displaying contributions from multiple genetic and environmental factors. In this study, we analyzed possible genetic factors that increase susceptibility to this widespread inflammatory disease. Materials and methods: A total of 176 adult patients, including 78 patients with sinonasal polyposis and 98 healthy controls, were analyzed for IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms using polymerase chain reaction and enzyme restriction. Results: IL-1RN and IL-4 VNTR polymorphisms were notably associated with sinonasal polyposis (P = 0.0001 and P = 0.036, respectively); however, regarding the IL-2(-330) gene polymorphism, no significant difference was shown between the patient and control groups (P = 0.235). Conclusions: Our study indicates that the RN2 allele of IL-1RN and the RP1 allele of IL-4 might be risk factors for developing sinonasal polyposis.

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“… 2007 ) and gastritis (Kulmambetova et al. 2014 ). These 2 polymorphisms ( IL1RN VNTR and IL1B -511C > T) are located within different regions of genes.…”

Section: Discussionmentioning

confidence: 99%

A link between osteomyelitis and IL1RN and IL1B polymorphisms—a study in patients from Northeast Brazil

Souza¹,

Souza

et al. 2017

Acta Orthopaedica

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Background and purposeTreatment failure of osteomyelitis can result from genetic susceptibility, highlighting polymorphisms of the interleukin-1 (IL-1) family members, central mediators of innate immunity and inflammation. Polymorphisms are DNA sequence variations that are common in the population (1% or more) and represent multiple forms of a single gene. We investigated the association of IL1RNVNTR (rs2234663) and IL1B-511C > T (rs16944) polymorphisms with osteomyelitis development in patients operated on because of bone trauma.Patients and methods153 patients who fulfilled the inclusion criteria were enrolled from a referral public hospital for trauma. All the patients were followed up daily until hospital discharge and, after this, on an outpatient basis. Patients were treated with prophylactic antimicrobials and surgery according to traumatology service protocol. The IL1RNVNTR and the IL1B-511C > T polymorphisms were determined by PCR and PCR-RFLP, respectively.ResultsThe IL1RN*2/*2 genotype was associated (OR: 7; p < 0.001) with a higher risk of osteomyelitis and was also significantly associated with Staphylococcus aureus infection. The haplotypes (combination of different markers) *2-C and *2-T were also associated with osteomyelitis development.InterpretationIL1B-511C > T and IL1RNVNTR polymorphisms were associated with osteomyelitis development, which may have implications for patients with bone traumas. These data may be relevant for new therapeutic strategies for this disease.

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Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Cited by 23 publications

References 34 publications

Identification and Functional Analysis of Differentially Expressed Genes Related to Metastatic Osteosarcoma

Identification and Functional Analysis of Differentially Expressed Genes Related to Metastatic Osteosarcoma

IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis

A link between osteomyelitis and IL1RN and IL1B polymorphisms—a study in patients from Northeast Brazil

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