Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis

Abstract

ABSTRACT. We conducted a hospital-based case-control study to assess the association between IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G polymorphisms and the risk of liver cirrhosis in a Chinese population. This 1:1-matched case-control study included 192 patients from the Chinese PLA General Hospital. Genotypes of IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G were detected by polymerase chain reaction amplification-restriction fragment length polymorphism analysis. Conditional regression analysis showed that individuals carrying the IL-10-1082 G allele had an only slightly increased risk of liver cirrhosis, with an adjusted odds ratio (95% confidence interval) of 2.14 (0.97-1.68). However, we did not identify a significant association between polymorphisms in IL-10-592 A/C and IL-10-819 C/T and the risk of liver cirrhosis. These findings may provide important clues for future studies of early detection screening of liver cirrhosis.

Analysis of the Factors Related to Liver Cirrhosis

“…In liver cirrhosis, liver cells are destroyed without being regenerated, and they become solid and are decreased. 1 - 4 …”

IL10 rs1800896 polymorphism is associated with liver cirrhosis and chronic hepatitis B

“…Several research teams have reported an association between the IL10 gene polymorphism and liver cirrhosis (Ramezani et al, 2012;Jin et al, 2014;Guo et al, 2015;Liu et al, 2015). Ramezani et al (2012) suggested that the IL10-592 polymorphism is associated with the outcomes of HBV infection, such as chronic hepatitis, occult HBV infection, liver cirrhosis, or hepatocellular carcinoma.…”

“…Jin et al (2014) found that the IL10-592 polymorphism increases the risk of liver cirrhosis, and has an association with chronic hepatitis B infection in the Chinese population. Liu et al (2015) also conducted a study in a Chinese population, and found that the IL10-1082 polymorphism was correlated with increased risk of liver cirrhosis. Liu et al (2015) reported that IL-10-592 was associated with the development of HCV-related liver cirrhosis in a Japanese population.…”

“…Liu et al (2015) also conducted a study in a Chinese population, and found that the IL10-1082 polymorphism was correlated with increased risk of liver cirrhosis. Liu et al (2015) reported that IL-10-592 was associated with the development of HCV-related liver cirrhosis in a Japanese population. In our study, we found that the IL10 rs1800896 polymorphism was associated with the development of liver cirrhosis, but further studies with a large sample size are needed to confirm our results.…”

Administration of simvastatin halts progression of cirrhosis via up-regulating expression of miR-34a and interleukin-10 in rats

“…Located on chromosome (1q31-1q32), the gene encoding IL-10 is about 4.7 kb and includes five exons and four introns [33]. A few studies have investigated the effect of IL-10 gene polymorphisms on the susceptibility to liver cirrhosis, although their conclusions were inconsistent [34]. For example, it was shown that the rs1800896 polymorphism of IL-10 was associated with the elevated risk of liver cirrhosis, particularly in patients suffering from chronic infection of hepatitis B [35].…”