[Purpose] The aim of this study was to find biochemical markers related to low bone mineral density in Korean adults. [Subjects and Methods] From August 1 to September 15, 2013, subjects receiving medical checkups were classified as lumbar spine bone normal, osteopenic, or osteoporotic using a bone mineral densitometer. Next, age, body mass index, and biochemical parameter differences were compared among the three groups. [Results] The results revealed that, the relevant factors were maximum blood pressure, minimum blood pressure, bone mineral density, total bilirubin, alkaline phosphatase (ALP), fasting blood glucose, iron, neutrophils, monocytes, and eosinophils. The bone mineral density of patients with osteoporosis was 0.763 times lower than that of normal subjects. The total bilirubin level of patients with osteoporosis was 0.45 times lower than that of normal subjects. The alkaline phosphatase level of patients with osteopenia was 1.059 times higher than that of normal subjects, and that in patients with osteoporosis was 1.088 times higher than that in normal subjects. The fasting blood glucose level of patients with osteoporosis was 0.963 times lower than that of normal subjects. The iron level of patients with osteoporosis was 0.986 times lower than that of normal subjects. [Conclusion] In conclusion, osteoporosis is a representative disease in elderly women due to aging and menopause, and more active interest should be taken for prevention and treatment.
Objectives:The purpose of this study was to find the correlations between biochemical study and liver cirrhosis.Methods:The patients had liver biopsy to check the degree of their liver fibrosis, from August 2013 to August 2014 at the current medical center. In order to find the etiology of hepatitis, a research was done on gender, age, weight, and biochemical study through the investigation of subjects’ medical record and medical history. For biochemical study, we examined hemoglobin, platelets, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, gamma-glutamyl transferase (GGT), prothrombin time (PT), and international normalised ratio (INR). We also analyzed the factors that are related to liver cirrhosis.Results:As a result, the patients at liver cirrhosis F≥2 stage showed 0.973, which is higher than the patients at FO stage with 0.943. F≥2 stage of hemoglobin was 0.544, which is lower than FO stage of hemoglobin with 0.817. Platelet count in F≥2 stage was 0.417, which is higher than FO stage with 0.074. For Albumin, F≥2 stage was 0.155 when F0 stage was 0.135. ATS’s F≥2 stage was 0.665, which is 6 times higher than FO stage with 0.100. Moreover, in the case of GGT, F≥2 stage was higher with 0.492 than FO stage with 0.078.Conclusions:In conclusion, it was confirmed that there is an increase in liver cirrhosis in the following general characteristics and biochemical factors: increase of age, increase of GGT, decrease of albumin, increase of the total bilirubin, and growth of INR (International Normalized Ratio).
[Purpose] This study was designed to study the correlation between biochemical tests and fatty liver. [Subjects and Methods] The study subjects were 242 people who received an abdominal ultrasound examination at a general hospital in Seoul, Korea, from March 2012 to March 2013. After the abdominal ultrasound examination, the subjects were categorized according to the presence or absence of fatty liver (n = 118 and 124, respectively). [Results] Comparison of biochemical markers revealed that glucose, total protein, aspartate transminase, alanine transaminase and triglyceride were higher in fatty liver patients. Risk analysis of general characteristics determined that hypertensive and diabetic patients had a 2.475- and 2.026-times greater risk of onset of fatty liver, respectively. The comparison of fatty liver with individual characteristics and biochemical markers revealed a 1.804-times greater chance of fatty liver when total protein was high, 0.964-times greater chance when high density lipoprotein was elevated and 1.204-times greater chance when triglyceride was elevated. When hypertension became severe, the chance of experiencing onset of fatty liver was 2.848 times higher. [Conclusion] Fatty liver is a representative disease of obese people in general and more active attention is necessary for its prevention and treatment. A direct cause of fatty liver was not found. Large-scale prospective studies will be required.
Objectives:The aim of this study was to investigate the difference of liver function changes according to the liver regeneration rate after liver transplantation through blood tests.Methods: Fifty donors, who underwent computed tomography (CT) 3D volumetry, were analyzed before and after liver transplantation. CT 3D volumetry was used as a study method to measure the mean liver regeneration volume and regeneration rate. Then, blood levels were measured including alanine transaminase (ALT), aminotransferase (AST), gamma-glutamyl transpeptidase (GGT) and total bilirubin.Results: The liver regeneration rate rapidly increased from 39.13±4.91% befoone1 month and 90.31±13.09% 16 months after surgery furthermore. Blood levels rapidly increased 7 days after surgery and then decreased 16 months after surgery compared to the state before surgery.Conclusion:This study results could be used as a basis for the prognosis of future liver transplantations.
[Purpose] The purpose of this study was to carry out a comparitive analysis of hepatic fibrosis results of the liver hardness of patients with chronic liver disease as measured by elastography (TE), shear wave elastography (SWE), and liver biopsy. [Subjects and Methods] This study was a retrospective analysis of 304 patients who underwent SWE and TE before and after liver biopsy, taken from among patients who had been checked for liver fibrosis by liver biopsy between August 2013 and August 2014. We used receiver operating characteristic (ROC) curve to prove the diagnostic significance of liver stiffness, and then analyzed the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of SWE and TE, as well as the kappa index through cross-analysis of SWE, TE, and liver biopsy. [Results] For liver hardness, the sensitivity of SWE was 84.39%, the specificity of SWE was 97.92%, the accuracy of SWE was 87.33%, the positive predictive value of SWE was 99.32%, and the negative predictive value of SWE was 63.51%. The sensitivity of TE was 94.80%, the specificity of TE was 77.08%, the accuracy of TE was 90.95%, the positive predictive value of TE was 93.97%, and the negative predictive value of TE was 80.43%. [Conclusion] It is our opinion that SWE and TE are non-invasive methods that are more effective than the invasive methods used for diagnosing liver hardness. Invasive methods cover only a section of liver tissue, and are more likely to cause side effects during biopsy.
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