Analysis of the Factors Related to Liver Cirrhosis

Abstract

Objectives:The purpose of this study was to find the correlations between biochemical study and liver cirrhosis.Methods:The patients had liver biopsy to check the degree of their liver fibrosis, from August 2013 to August 2014 at the current medical center. In order to find the etiology of hepatitis, a research was done on gender, age, weight, and biochemical study through the investigation of subjects’ medical record and medical history. For biochemical study, we examined hemoglobin, platelets, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, gamma-glutamyl transferase (GGT), prothrombin time (PT), and international normalised ratio (INR). We also analyzed the factors that are related to liver cirrhosis.Results:As a result, the patients at liver cirrhosis F≥2 stage showed 0.973, which is higher than the patients at FO stage with 0.943. F≥2 stage of hemoglobin was 0.544, which is lower than FO stage of hemoglobin with 0.817. Platelet count in F≥2 stage was 0.417, which is higher than FO stage with 0.074. For Albumin, F≥2 stage was 0.155 when F0 stage was 0.135. ATS’s F≥2 stage was 0.665, which is 6 times higher than FO stage with 0.100. Moreover, in the case of GGT, F≥2 stage was higher with 0.492 than FO stage with 0.078.Conclusions:In conclusion, it was confirmed that there is an increase in liver cirrhosis in the following general characteristics and biochemical factors: increase of age, increase of GGT, decrease of albumin, increase of the total bilirubin, and growth of INR (International Normalized Ratio).

Hepatoprotective Effects of a Proprietary Glycyrrhizin Product during Alcohol Consumption: A Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study

“…When subjects in the blank control (alcohol only) group consumed the alcoholic drink, increases in the liver enzymes AST, ALT, and GGT occurred as compared with baseline (Tables 1-3). Increases in levels of these enzymes serve as biomarkers of liver damage and compromised liver health (Deshpande et al, 2014;Li et al, 2015;Kim et al, 2015;Qureshi et al, 2015). However, when the subjects consumed the glycyrrhizin/D-mannitol product in combination with the alcohol (active group), no significant increases in liver enzymes were observed, suggesting protection against alcohol-induced liver damage (Tables 1-3).…”

“…Biomarkers are biological indicators of the state of health of an organ or tissue. Various common biomarkers useful in assessing the existence, progression, and pathogenesis of alcoholic liver disease include measurements of the blood serum levels of the enzymes aspartate aminotransferase (AST), gammaglutamyltransferase (GGT), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) (Deshpande et al, 2014;Li et al, 2015;Kim et al, 2015;Qureshi et al, 2015). Elevations of the serum levels of these enzymes occur when the liver is damaged as is the case with alcoholic liver disease.…”

“…Decreases in GSH content occur in blood and tissues as it reacts with and neutralizes ROS and free radicals. Therefore, a decrease in hepatic GSH is associated with an increase in oxidative stress as occurs in the case of alcoholic liver disease (Deshpande et al, 2014;Li et al, 2015;Kim et al, 2015;Qureshi et al, 2015;Han et al, 2016).…”

Respuesta activa profibrótica en sangre periférica en pacientes cirróticos

“…En este estudio, la elevación de las diversas enzimas hepáticas: Aspartato aminotransferasa (AST), ALT (Alanina amino-transferasa), Gamma-glutamil transpeptidasa (GGT) y Fosfatasa Alcalina (ALP) coincide con los hallazgos descritos en otros estudios (88). Por un lado, AST y ALT son enzimas intracelulares que catalizan reacciones de transaminación reversibles de los alfa-aminoácidos y se liberan a circulación en grandes cantidades cuando hay daño en la membrana del hepatocito.…”

“…Existen publicaciones al respecto en las que se obtienen resultados similares (9,88). Puesto que se trata de pacientes habitualmente en estadios de enfermedad menos avanzados que aquellos que tienen indicación de trasplante por cirrosis avanzada.…”