<i>In Vitro</i>Study of Hydroxyapatite Coatings on Fibrin Functionalized/Pristine Graphene Oxide for Bone Grafting

Deepachitra, R.; Nigam, Rashi; Purohit, Shiv Dutt; Kumar, B. Santhosh; Hemalatha, Thiagarajan; Sastry, T. P.

doi:10.1080/10426914.2014.994758

Cited by 37 publications

(28 citation statements)

References 38 publications

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“… The number of publications on Graphene-based HA composites from year 2009–2016 (2009 [ 16 ], 2011 [ [17] , [18] , [19] ], 2012 [ [20] , [21] , [22] , [23] , [24] ], 2013 [ [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] ], 2014 [ [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] ], 2015 [ [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] ...…”

Section: Introductionunclassified

An overview of graphene-based hydroxyapatite composites for orthopedic applications

Xiong

Yan

et al. 2018

Bioactive Materials

188

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Hydroxyapatite (HA) is an attractive bioceramic for hard tissue repair and regeneration due to its physicochemical similarities to natural apatite. However, its low fracture toughness, poor tensile strength and weak wear resistance become major obstacles for potential clinical applications. One promising method to tackle with these problems is exploiting graphene and its derivatives (graphene oxide and reduced graphene oxide) as nanoscale reinforcement fillers to fabricate graphene-based hydroxyapatite composites in the form of powders, coatings and scaffolds. The last few years witnessed increasing numbers of studies on the preparation, mechanical and biological evaluations of these novel materials. Herein, various preparation techniques, mechanical behaviors and toughen mechanism, the in vitro/in vivo biocompatible analysis, antibacterial properties of the graphene-based HA composites are presented in this review.

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Section: Introductionunclassified

An overview of graphene-based hydroxyapatite composites for orthopedic applications

Xiong

Yan

et al. 2018

Bioactive Materials

188

122

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“…In this regard, graphene oxide (GO) and natural polymers (i.e., gelatin, alginate, fibrin, etc.) have gained significant attention (Deepachitra et al, 2015;Kumar et al, 2019;Purohit et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Graphene oxide, a graphene-derivative has distinctive properties such as large surface area, good mechanical and chemical properties (Deepachitra et al, 2015;Kumar et al, 2019;Purohit et al, 2019). Additionally, the functional groups present on the GO surface offer reactive sites, which enable it to facilitate cellular adhesion and chemical interactions with other materials (Deepachitra et al, 2015;Janković et al, 2015;Kumar et al, 2018). These exceptional properties make GO a potential material for its use in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Graphene Oxide and Nanohydroxyapatite Reinforced Gelatin–Alginate Nanocomposite Scaffold for Bone Tissue Regeneration

et al. 2020

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Graphene oxide (GO) and nanohydroxyapatite (nHAp) proved to be a potential material for bone tissue-regeneration applications. Therefore, GO and nHAp reinforced porous polymeric nanocomposite scaffolds have been gaining significant research thrust. In this study, GO and nHAp based nanocomposite was synthesized and used as a reinforcing agent to develop gelatin-alginate (GA)-based three-dimensional porous polymeric nanocomposite scaffold. The polymeric nanocomposite scaffold (nHAp-GO/GA) was fabricated by using freeze-drying process, which may show a synergistic effect of each of the components for tissue regeneration. The scaffold demonstrates good physico-chemical properties. The porous microstructure of the scaffold is evidenced by Field emission scanning electron microscopy (FESEM). High swelling of the scaffold in presence water, indicates that the scaffold is highly hydrophilic, which implies the suitability of the scaffold for tissue regeneration. Further, the incorporation of nHAp-GO enhances the compressive strength of the scaffold while reduces the rate of biodegradation, which is good for bone tissue engineering. The scaffold is biocompatible. In vitro cell study with MG-63 bone cells demonstrates the synergistic effect of each of the components of the scaffold, on mineral deposition. Therefore, it can be concluded that nHAp-GO/GA polymeric nanocomposite scaffold can be a potential candidate for bone tissue regeneration.

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“…Controlling the doping of a HA–graphene composite with nickel allowed for enhanced mechanical properties and mineralization while maintaining compatibility with human FOB 1.19 osteoblasts . Additionally, fibrin‐functionalized GO was used as a nucleation site for HA growth, facilitating osteoblast growth and maturation …”

Section: Go As a Scaffold For Bone Regenerationmentioning

confidence: 99%

Graphene oxide as a scaffold for bone regeneration

Holt

Wright

Arnold

et al. 2016

WIREs Nanomed Nanobiotechnol

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Graphene oxide (GO), the oxidized form of graphene, holds great potential as a component of biomedical devices, deriving utility from its ability to support a broad range of chemical functionalities and its exceptional mechanical, electronic, and thermal properties. GO composites can be tuned chemically to be biomimetic, and mechanically to be stiff yet strong. These unique properties make GO-based materials promising candidates as a scaffold for bone regeneration. However, questions still exist as to the compatibility and long-term toxicity of nanocarbon materials. Unlike other nanocarbons, GO is meta-stable, water dispersible, and autodegrades in water on the timescale of months to humic acid-like materials, the degradation products of all organic matter. Thus, GO offers better prospects for biological compatibility over other nanocarbons. Recently, many publications have demonstrated enhanced osteogenic performance of GO-containing composites. Ongoing work toward surface modification or coating strategies could be useful to minimize the inflammatory response and improve compatibility of GO as a component of medical devices. Furthermore, biomimetic modifications could offer mechanical and chemical environments that encourage osteogenesis. So long as care is given to assure their safety, GO-based materials may be poised to become the next generation scaffold for bone regeneration. WIREs Nanomed Nanobiotechnol 2017, 9:e1437. doi: 10.1002/wnan.1437 For further resources related to this article, please visit the WIREs website.

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In VitroStudy of Hydroxyapatite Coatings on Fibrin Functionalized/Pristine Graphene Oxide for Bone Grafting

Cited by 37 publications

References 38 publications

An overview of graphene-based hydroxyapatite composites for orthopedic applications

An overview of graphene-based hydroxyapatite composites for orthopedic applications

Fabrication of Graphene Oxide and Nanohydroxyapatite Reinforced Gelatin–Alginate Nanocomposite Scaffold for Bone Tissue Regeneration

Graphene oxide as a scaffold for bone regeneration

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