An overview of graphene-based hydroxyapatite composites for orthopedic applications

Li, Ming; Xiong, Pan; Yan, Feng; Li, Sijie; Ren, Chang­hong; Yin, Zhichen; Li, Ang; Li, Huafang; Ji, Xunming; Zheng, Yufeng

doi:10.1016/j.bioactmat.2018.01.001

Cited by 188 publications

(134 citation statements)

References 153 publications

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“…Innate osteoinductivity has been suggested for GO (40)(41)(42)(43), but the effect was minimal under these conditions. Of 10 injections of GO with BMSCs, only 1 showed the presence of cyan donor cells after 8 wk, showing a weak ability of GO to retain donor cells at the implantation site (Fig.…”

Section: Processing Into 3d Scaffolds With Osteomimetic Mechanical Prmentioning

confidence: 94%

Phosphate graphene as an intrinsically osteoinductive scaffold for stem cell-driven bone regeneration

Arnold

Holt

Daneshmandi

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Synthetic, resorbable scaffolds for bone regeneration have potential to transform the clinical standard of care. Here, we demonstrate that functional graphenic materials (FGMs) could serve as an osteoinductive scaffold: recruiting native cells to the site of injury and promoting differentiation into bone cells. By invoking a Lewis acid-catalyzed Arbuzov reaction, we are able to functionalize graphene oxide (GO) to produce phosphate graphenes (PGs) with unprecedented control of functional group density, mechanical properties, and counterion identity. In aqueous environments, PGs release inducerons, including Ca2+ and PO43−. Calcium phosphate graphene (CaPG) intrinsically induces osteogenesis in vitro and in the presence of bone marrow stromal cells (BMSCs), can induce ectopic bone formation in vivo. Additionally, an FGM can be made by noncovalently loading GO with the growth factor recombinant human bone morphogenetic protein 2 (rhBMP-2), producing a scaffold that induces ectopic bone formation with or without BMSCs. The FGMs reported here are intrinsically inductive scaffolds with significant potential to revolutionize the regeneration of bone.

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Section: Processing Into 3d Scaffolds With Osteomimetic Mechanical Prmentioning

confidence: 94%

Phosphate graphene as an intrinsically osteoinductive scaffold for stem cell-driven bone regeneration

Arnold

Holt

Daneshmandi

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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“…To date, hybrid nanomaterials, composed of HAp and graphene derivatives have been examined extensively both as such and with the addition of other (biopolymer) components such as chitosan (Solìs Moré et al, ), silk fibroin (Wang et al, ) or hyaluronic acid (Li et al, , ). In order to synthesize these materials, more than one technique has been used.…”

Section: Introductionmentioning

confidence: 99%

In situ syntheses of hydroxyapatite‐grafted graphene oxide composites

Iacoboni

Perrozzi

Macera

et al. 2019

J Biomedical Materials Res

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In this study, we examined three different syntheses of hydroxyapatite (HAp) and graphene oxide–hydroxyapatite (GO–HAp) composites with a GO content of 9, 33, and 43% wt. The materials were prepared from various precursors of calcium and phosphate ions, using an in situ synthesis method, with mild conditions to avoid reducing the GO. In situ bonding technology proposed that calcium ions bond with GO at first and then HAp nanoflakes in situ grow on GO sheets, forming GO–HAp nanocomposite. The aim of the present work was to analyze the differences due to the use of different starting reagents and verify, with the addition of increasing amounts of GO, the changes in morphology, crystallinity, and solubility of the obtained HAp composites. Detailed structural and morphological characterization studies of the composites were carried out using scanning electron microscopy, energy dispersive X‐ray spectrometry, X‐ray powder diffraction, Raman spectroscopy, and Fourier transform infrared spectroscopy. We found that GO sheets act as a nucleation site for HAp mineralization, but we observed a loss of the crystallographic order due to the intercalation of the graphenic sheets between the HAp particles.

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“…This phenomenon is considered the starting point for the loading of transition ions . The incorporation of GO into the nanoporous scaffold would help transfer Ca 2+ toward hydroxyl groups of GO leading to the formation of calcium phosphate layers …”

Section: Resultsmentioning

confidence: 99%

Graphene oxide incorporated polycaprolactone/chitosan/collagen electrospun scaffold: Enhanced osteogenic properties for bone tissue engineering

et al. 2019

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This in vitro study aimed to evaluate the physicochemical and biological activity of the polycaprolactone/chitosan/collagen scaffolds incorporated with 0, 0.5, 3, and 6 wt% of graphene oxide (GO). Using standard tests and MG-63 cells, the characteristics of scaffolds were evaluated, and the behavior of osteoblasts were simulated, respectively. A non-significant decrease in nanofibers diameter was noted in scaffolds with a higher ratio of GO. The hydrophilicity and bioactivity of the scaffold surface, as well as cell attachment and proliferation, increased in correspondence to an increase in GO. The higher ratio of GO also improved the osteogenesis activity.GO increased the degradation rate, but it was negligible and seemed not enough to endanger stability. Modifying the scaffolds with GO did not make a significant change to the antibacterial effect.

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An overview of graphene-based hydroxyapatite composites for orthopedic applications

Cited by 188 publications

References 153 publications

Phosphate graphene as an intrinsically osteoinductive scaffold for stem cell-driven bone regeneration

Phosphate graphene as an intrinsically osteoinductive scaffold for stem cell-driven bone regeneration

In situ syntheses of hydroxyapatite‐grafted graphene oxide composites

Graphene oxide incorporated polycaprolactone/chitosan/collagen electrospun scaffold: Enhanced osteogenic properties for bone tissue engineering

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