Histopathological study of breast lesions

Abstract

Objectives: To study the histopathological features of neoplastic and non neoplastic lesions of breast. To correlate the pathological findings with clinical parameters. Design and methods: We have studied total 161 cases of breast lesions over a period of two years in our institute. The specimens were received in histopathology section of our department. Detailed gross examination of specimens was done followed by fixation, thorough sampling, and tissue processing. The different lesions were studied by histopathological examination and analysed. Neoplastic lesions were classified according to the WHO classification (2012). Results: Out of the 161 cases, 128 cases had neoplastic lesions and 32 cases had non-neoplastic lesions, and one case had coexistent neoplastic and nonneoplastic lesions. Two cases had dual neoplastic lesions. Out of the total 129 cases with neoplastic lesions, 76 cases had benign breast tumors, 53 cases had malignant breast tumors, and 2 cases had precursor lesions. Fibroadenoma was the most common benign tumour with 60 cases. Invasive carcinoma no special type was the most common malignant tumour with 43 cases. Special subtypes of invasive carcinoma found in our study were metaplastic carcinoma (3 cases) and mucinous carcinoma (1 case). The most common nonneoplastic lesion was mastitis with 12 cases, followed by duct ectasia and fibrocystic change. There were 4 cases of gynaecomastia. All the tumors involved upper outer quadrant most frequently. The benign tumors were most frequent in second, third and fourth decades, malignant tumours were seen beyond 4 th decade. The nonneoplastic lesions were common in 4 th decade. Conclusion: Histopathological study is important in the management of breast lumps

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“…Most of the benign tumors were found in reproductive age group; the present study noted the frequency of occurrence of fibroadenoma to be 90.08% of all benign tumors, which was similar to that reported by Mudholkar et al 5 i.e. 87.40% and much higher than 78.94% reported by Sulhyan et al 4 . The second common benign tumor observed in our study was benign phylloid tumor, comprising 4.58% out of all benign tumors.…”

“…In the present study, we observed that, maximum number of cases of benign breast tumors occurred between 11-20 years, followed by 3rd decade. Sulhyan KR et al 4 4 and sharma K et al 8. In present study, left breast involvement was more common than right (51.83%); this observation agreed with that of the other authors 10,11. Most common location for breast lesion was upper outer quadrant; the observations in the present study (45.85%) concurred with those reported previously 4,5 11.…”

Clinical and histopathological correlation of breast lesions

“…In the present study, we observed that maximum number of cases occurred between 14-24 years, Sylhan et al, reported maximum number of cases occurred between 11-20 years followed by 3 rd and 4 th decade. 2 Fibroadenoma with Infarction was found in one case. Varghas et al, reported infarcted myxoid fibroadenoma following fine needle aspiration.…”

“…Sulhyan et al, reported incidence of 2.5% cases Olu Eddo et al, reported incidence of 2%. 2,18 Haque et al, reported an incidence of 8.66% and average age of 20 years. 4 Johnson et al, stated that initial first step should be ruling out pseudogynecomastia by history taking and physical examination.…”

“…1 This may be due to increasing public awareness of breast cancer which is presently the most common female malignancy worldwide. 2 Recognition of different neoplastic and nonneoplastic breast lesions is important for the differential diagnosis from malignant lesions and ultimately for the management of the patients with breast disease. Authors have studied and analysed various neoplastic and nonneoplastic breast lesions from the specimens received…”