Clinical and histopathological correlation of breast lesions

Sharma, Kavita; Vyas, Sameer; Dhayal, Subhash

doi:10.18203/2320-6012.ijrms20181295

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…Total 14 cases (6.42%) of acute and chronic inflammation were found in present study. This finding is comparable with Sulhyan et al 4 and Sharma K et al 8 who observed the incidence mastitis as 7.45% and 7.05%. Out of 14 cases, all were in their reproductive period and 3 patients were lactating.…”

Section: Histopathological Diagnosis: Neoplastic Lesionssupporting

confidence: 89%

“…All of the metastasis were from invasive carcinoma, no special type. Sulhyan et al 4 and Sharma K et al 8 , found it in 61.53% and 70% cases of invasive carcinoma -no special type(NST). In our study, we came across two cases of non-invasive carcinoma.…”

Section: Histopathological Diagnosis: Neoplastic Lesionsmentioning

confidence: 98%

“…Malignant tumors were obeserved in 6th decade. Mudholkar et al5 and Sharma K et al8 , also found maximum incidence in 6 th decade .The cases of developmental disorders were diagnosed in their 2 nd decade. Most of the inflammatory lesions are found in reproductive age group; in this study maximum inflammatory lesions were present between 31-40 years.…”

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confidence: 90%

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Untitled

2019

MIJOPAT

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Background: The female breast is one of the most commonly biopsied tissues because of the myriads of diseases and lesions that arise from it. Timely and accurate diagnosis of a breast lump can not only alleviate anxiety but also early intervention can be lifesaving. In India, breast cancer forms the second most common malignancy after cervical cancer and is detected in 20/1,00,000 women. Objectives: To study the clinic pathological aspect and histopathological patterns of neoplastic and non neoplastic breast lesions. Material and Method: A prospective study was carried out on 218 cases in tertiary care institute at S.R.T.R. GMC Ambajogai. Breast lesions were evaluated over a period of one and half year. The specimen were routinely processed and stained with Heamatoxylin and Eosin (HandE) and examined microscopically. Cases included in this study were of non-neoplastic and neoplastic breast lesions which included incisional biopsies, lumpectomy and all types of mastectomy specimens from surgical department at rural hospital. Results: Among 218 cases, 181 were neoplastic and 37 cases were non neoplastic. Majority of cases were fibroadenoma i.e. 118 cases. Invasive carcinoma-no special type (NST) was the most common malignant neoplasm i.e. 43 cases. The most common inflammatory nonneoplastic lesion was mastitis with 14 cases and benign epithelial lesion was fibrocystic change. Most of the breast tumors were noted in left breast and involved upper outer quadrant most frequently.The nonneoplastic lesions were common in third decade, benign tumour in second and third decades and malignant tumours were common in sixth decades. Conclusions: This study highlights the importance of histopathological examination in breast lumps not only in establishing the final diagnosis, but also in predicting the prognosis of breast neoplasms.

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Section: Histopathological Diagnosis: Neoplastic Lesionssupporting

confidence: 89%

Section: Histopathological Diagnosis: Neoplastic Lesionsmentioning

confidence: 98%

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2019

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“…Interestingly, analogous to our own findings, MRI appears to overestimate DOI consistently. Tumor specimen shrinkage due to formalin fixation has been suggested as a potential mechanism to explain this phenomenon [27]. If this hypothesis holds true, then the radiographic estimation of DOI could be superior to pathological measurement.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Determination of Depth of Invasion in Oral Cavity Squamous Cell Carcinoma by Standard Cross-Sectional Imaging With Computed Tomography and Positron Emission Tomography/Computed Tomography

Naha¹,

Biedermann²,

Nada³

et al. 2023

Cureus

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BackgroundDepth of invasion (DOI) is a known indicator of metastatic potential in oral cavity squamous cell carcinoma (SCC). Our purpose was to investigate the accuracy of preoperative determination of DOI in oral cavity SCC by computed tomography (CT) and positron emission tomography/computed tomography (PET/CT). MethodologyA retrospective study was performed using consecutive patients with histologically proven oral cavity SCC presenting to our otorhinolaryngology department between January 2014 and July 2019 who underwent preoperative contrast-enhanced CT and/or PET/CT. Pathological assessment of DOI was determined by a review of pathology reports. The degree of DOI determined by radiographic studies was correlated to pathology results. ResultsA total of 79 patients were screened of whom appropriate radiographic studies were available for 63 patients. The mean DOI by pathological assessment was 12.3 ± 9.1 mm. CT and PET/CT determined depth both correlated with pathological DOI (r = 0.710; p < 0.001, r = 0.798; p < 0.001). No significant correlation was seen for CT-determined depth (r = 0.136; p = 0.709) or PET-determined depth (r = 0.234; p = 0.707) with pathologically confirmed superficial tumors (<5 mm). For patients with pathological tumor depth >10 mm, CT and PET determined depth both correlated with pathological depth (r = 0.577; p = 0.002, r = 0.668; p = 0.001). The sensitivity and specificity of CT and PET for the identification of deep invasion were 88.2% and 41.7% and 52.9% and 50%, respectively. ConclusionsDOI measurement is feasible with routine preoperative CT and PET/CT images and is comparable to pathological measurement in patients with oral cavity SCC.

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“…Studies conducted by Shashikala R et al [20] . And Sharma K et al [21] . Also found fibrocystic disease as the most common lesion in peritumoral area that accounts for 38% and 34.78% respectively.…”

Section: Discussionmentioning

confidence: 99%

Histopathological study of benign proliferative breast lesions in peritumoral area of carcinoma breast - experience in a tertiary care centre

N¹,

PV²,

Samly³

et al. 2022

Int. J. Clin. Diagn. Pathol.

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Background: Lesions of breast has gained more importance worldwide due to increase in mortality and morbidity associated with breast cancer. In India increase in incidence is due to life style changes and use of hormones. Presence of different proliferative lesions adjacent to malignancy in the same breast proves that carcinogenesis of breast is a multistep process. Women with proliferative breast lesions are more prone to develop carcinoma. Knowledge in carcinogenesis of breast will define the high risk group that improves the screening for carcinoma and management Aim: The aim is to study the histopathological types of carcinoma breast and benign proliferative breast lesions in peritumoral area. Materials and Method:This study was a cross-sectional study conducted for a period of 2 years. A total of 85 cases that satisfy the inclusion criteria were included in the present study. Samples were collected in 10% formalin. All the tissue specimens were processed and paraffin embedded. The sections were stained with Hematoxylin and Eosin. Histopathology findings were noted. Results thus obtained was analyzed using SPSS 20.0 version. Statistical analysis was done using Chi square test. Results: Common age group affected was between 51 to 60 years seen in 30(35.3%) cases. Lesions were predominantly seen in right breast 39 (45.9%). Invasive carcinoma breast No Special Type was the most common malignant lesion (85.9%). Non proliferative breast lesion was common in peritumoral area 46(54.1%). Statistical significance was observed between histopathological diagnosis, tumour size, lymph node status and peritumoral benign proliferative breast lesions. Conclusion: Proliferative epithelial lesions are at increased risk of subsequent breast cancer. Non proliferative breast diseases are the most common peritumoral lesion in the present study. Even though the risk of transformation to malignancy is less, careful follow-up with clinical breast examination and annual mammographic screening every 6 to 12 months can identify the changes and further it helps to reduce the occurrence of invasive breast cancer.

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Clinical and histopathological correlation of breast lesions

Cited by 6 publications

References 8 publications

Untitled

Untitled

Preoperative Determination of Depth of Invasion in Oral Cavity Squamous Cell Carcinoma by Standard Cross-Sectional Imaging With Computed Tomography and Positron Emission Tomography/Computed Tomography

Histopathological study of benign proliferative breast lesions in peritumoral area of carcinoma breast - experience in a tertiary care centre

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