Hepatoprotective activity of <i>Etlingera elatior</i> (Jack) R.M. Smith extract against ccl4 -induced hepatic toxicity in male wistar rats

Fristiohady, Adryan; Wahyuni, Wahyuni; Yusuf, Muhammad; Malik, Fadhliyah; Purnama, La Ode Muhammad Julian; Bafadal, Mentarry; Leorita, Mesi; Jabar, Asriullah; Malaka, Muhammad Hajrul; Sahidin, Idin

doi:10.5958/0974-360x.2020.00807.0

Cited by 14 publications

(5 citation statements)

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“…Damage cells in the liver could be known by doing biochemical examination which is the measurement of SGOT and SGPT enzymes levels. SGPT and SGOT enzymes are enzymes that come out into the blood when the damage occurred in the liver cells (Victor, 2016;Fristiohady et al, 2020). The markers of liver damage is the increasing of SGOT or SGPT levels (Rosida, 2016).…”

Section: Resultsmentioning

confidence: 99%

Hepatoprotector Effect of Banana Peel (Musa paradisiaca Sapientum) on Paracetamol Induced Rats

Pusmarani¹,

Ifaya²,

Putri³

2022

JFG

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Background: Liver disease is generally still a high prevalence in Indonesia. One of drug-induced liver injury is paracetamol. Banana peel (Musa paradisiaca Sapientum) has flavonoid compounds that could increasing the production of glutathione enzymes in the liver. Objectives: This research aims to determine the activity of banana peel induced by paracetamol. This research is an experimental with pre and post test control group design method. Material and Methods: This research is an experimental with pre and post test control group design method. Group I was given 0.05% Na CMC as negative control, group II was given paracetamol 180 mg/kgBB as induction control group, group III was given banana peel extract at dose 700 mg / kgBB, group IV was given banana peel extract at dose 1400 mg/kgBB, and group V was given banana peel extract at dose 2100 mg/kgBW. Results: The liver damage can be measured by SGOT/SGPT serum levels of rats. SPSS data analysis with Paired sample T test obtained the value of p = 0.003 for SGOT (serum glutamic oxaloacetic transaminase) and p = 0.000 for SGPT. Conclusions: Both SGOT and SGPT values have p <0.05 which indicates that banana peel (Musa paradisiaca Sapientum) methanol extract has hepatoprotector effect on paracetamol-induced rats.

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Section: Resultsmentioning

confidence: 99%

Hepatoprotector Effect of Banana Peel (Musa paradisiaca Sapientum) on Paracetamol Induced Rats

Pusmarani¹,

Ifaya²,

Putri³

2022

JFG

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“…Before studying soft corals, we have isolated and identified the structure of a novel molecule from a sponge Chlatria sp., called Clathruohate [1], and chemically screened a few sponges [2]. Antihyperlipidemia [3], anti-inflammatory [4], antioxidant capabilities and acute toxicity [5], as well as chemical and medicinal characteristics of soft coral Nepthea sp. [6] are just a few of the biological activities of sponges that have been noted.…”

Section: Introductionmentioning

confidence: 99%

Study In-vitro and in-silico of ethylacetate extract and fractions of soft coral Lobophytum sp. towards Artemia salina Brine Shrim (BSLT)

Sahidin,

Fristiohady,

Wahyuni

et al. 2023

BIO Web Conf.

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The article aims to describe the findings of chemical and pharmaceutical aspects of Lobophytum sp. from Southeast Sulawesi, Indonesia. Ethylacetate extract was fractionated by Vacuum liquid chromatography (VLC). Toxicity was evaluated by BSLT test, and the phytochemical screening and LCMSMS method were used to determine the chemical composition and molecular docking for in-silico study. The results showed that the ethylacetate extract was produced seven fractions namely Fraction A-G. The weight of each fraction was A (12.8% w/w), B (9.7%), C (10.1%), D (2.0%), E (7.0%), F (25, 3%) and G (11.5%). The toxicity potency of Fraction B is the most toxic with LC50 (mg/L) 26.70 ± 0.58. LCMSMS data indicated that the fraction B contains 19L-glukocyl-14-deoxy-11,12-didehydrographoside, 3-isoazmalicine, abietraticine, arachidonic acid, neociwujiaphenol, oxyphyliacinol, saurufuran B and some unidentified compounds with molecular formulas C37H46O7, C35H44O5, and C20H26O2. Based on computational simulations, Ar-Abietatriene and 3-Isoajmalicine have the potential to inhibit CDK-6. These compounds hinder the progression of the cell cycle and the proliferation of cancer cells by forming molecular interactions with residues Ile19, Val27, Ala41, Val77, Phe98, Val101, Leu152, and Ala162. This suggests their potential as anticancer agents. Thus, Fraction B can be continued for the anticancer evaluation.

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“…2 Liver damage can cause SGOT and SGPT to leak into the bloodstream. 3 Thus, SGOT and SGPT can be better indicators than others to detect liver damage because these two enzymes will increase fi rst, and the increase is more signifi cant when compared to other enzymes.…”

Section: Introductionmentioning

confidence: 99%

Cat’s Liver Disease Detection with SGOT and SGPT Evaluation as a Gold Standard Diagnosis

Desiandura

Rahayu²,

Wibisono³

2022

IJTID

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SGOT and SGPT are two enzymes found in the liver in large amounts. Therefore, elevated levels of these two enzymes in the blood indicate liver disease. This study aims to identify liver disease in cats in Surabaya through the levels of SGOT and SGPT in the blood as the gold standard of diagnosis. Samples came from stray cats and domesticated cats of random age, breed, and sex. The blood samples collected were 62 samples, consisting of 33 domestic cats and 29 samples from stray cats. This study showed that from 33 samples of domesticated cats, 19 samples had higher than normal levels of SGOT, and from 29 samples of stray cats, 27 samples had higher than normal levels of SGOT. For SGPT levels, from 33 samples of domesticated cats, six samples had higher than normal levels of SGPT, and from 29 samples of stray cats, six samples had higher levels of SGPT than average. Data analysis used an independent sample t-test with SPSS for Windows with a signiﬁ cance level of 0.05. The data analysis results showed no signiﬁ cant diﬀ erence, which means that the high levels of cat SGOT and SGPT enzymes did not signiﬁ cantly aﬀ ect the origin of the cat. Therefore, it can be concluded that high levels of SGOT and SGPT as the gold standard for detecting liver diseases can occur in all cats, including stray cats and domesticated cats.

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Hepatoprotective activity of Etlingera elatior (Jack) R.M. Smith extract against ccl4 -induced hepatic toxicity in male wistar rats

Cited by 14 publications

References 0 publications

Hepatoprotector Effect of Banana Peel (Musa paradisiaca Sapientum) on Paracetamol Induced Rats

Hepatoprotector Effect of Banana Peel (Musa paradisiaca Sapientum) on Paracetamol Induced Rats

Study In-vitro and in-silico of ethylacetate extract and fractions of soft coral Lobophytum sp. towards Artemia salina Brine Shrim (BSLT)

Cat’s Liver Disease Detection with SGOT and SGPT Evaluation as a Gold Standard Diagnosis

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